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1.发明申请QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS 失效具有5HT1型受体亲和力的喹啉和喹唑啉衍生物公开(公告)号：US20080280919A1
公开(公告)日：2008-11-13
申请号：US12166547
申请日：2008-07-02
申请人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Mark Bromidge , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco , Antonio Kuok Keong Vong , Simon Edward Ward
发明人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Mark Bromidge , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco , Antonio Kuok Keong Vong , Simon Edward Ward
IPC分类号： A61K31/496 , A61P25/24 , A61P25/22
CPC分类号： C07D401/12 , C04B35/632
摘要： Disclosed are methods for use of compounds of formula (I) in combination with other active substances in the treatment of CNS disorders such as depression or anxiety. wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description.
摘要翻译： 公开的是使用式（I）化合物与其它活性物质组合用于治疗CNS疾病如抑郁症或焦虑症的方法。 其中R 1，m，X，R 2，n，W，p，Y，Z，R 3，R 4 R 5和q具有如在说明书中定义的含义。
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2.发明申请Quinoline and Quinazoline Derivatives Having Affinity for 5HT1-Type Receptors 审中-公开喹啉和喹唑啉衍生物具有5HT1型受体的亲和力公开(公告)号：US20100204273A1
公开(公告)日：2010-08-12
申请号：US12766053
申请日：2010-04-23
申请人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Mark Bromidge , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco , Antonio Kuok, Keong Vong , Simon Edward Ward
发明人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Mark Bromidge , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco , Antonio Kuok, Keong Vong , Simon Edward Ward
IPC分类号： A61K31/4709 , A61P25/00 , A61P25/18
CPC分类号： C07D401/12 , C04B35/632
摘要： Disclosed are methods for use of compounds of formula (I) in the treatment of CNS disorders such as dysthymia, schizophrenia, panic disorder, obsessive compulsive disorder, post-traumatic stress disorder, pain, and memory disorders: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description.
摘要翻译： 公开了使用式（I）化合物治疗中枢神经系统疾病例如心境恶劣，精神分裂症，恐慌症，强迫症，创伤后应激障碍，疼痛和记忆障碍的方法：其中R1，m，X， R2，n，W，p，Y，Z，R3，R4，R5和q具有如说明书中定义的含义。
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3.发明授权Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors 失效对5HT1型受体具有亲和力的喹啉和喹唑啉衍生物公开(公告)号：US07459456B2
公开(公告)日：2008-12-02
申请号：US11687098
申请日：2007-03-16
申请人： Matteo Biagetti , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco
发明人： Matteo Biagetti , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco
IPC分类号： A61K31/496 , A61K31/517 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
CPC分类号： C07D401/12 , C04B35/632
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
摘要翻译： 提供式（I）化合物及其药学上可接受的盐：其中R1，m，X，R2，n，W，p，Y，Z，R3，R4，R5和q具有如说明书中所定义的含义。 还公开了其治疗方法及其在治疗中的用途，特别是CNS疾病如抑郁或焦虑症。
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4.发明授权Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors 失效对5HT1型受体具有亲和力的喹啉和喹唑啉衍生物公开(公告)号：US07732600B2
公开(公告)日：2010-06-08
申请号：US12540452
申请日：2009-08-13
申请人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Mark Bromidge , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco , Antonio Kuok Keong Vong , Simon Edward Ward
发明人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Mark Bromidge , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco , Antonio Kuok Keong Vong , Simon Edward Ward
IPC分类号： C07D213/38 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D401/12 , C04B35/632
摘要： Disclosed are methods for the preparation of compounds of formula (I): wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description.
摘要翻译： 公开了制备式（I）化合物的方法：其中R1，m，X，R2，n，W，p，Y，Z，R3，R4，R5和q具有如说明书中定义的含义。
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5.发明申请QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS 失效具有5HT1型受体亲和力的喹啉和喹唑啉衍生物公开(公告)号：US20090312546A1
公开(公告)日：2009-12-17
申请号：US12540452
申请日：2009-08-13
申请人： Markus BERGAUER , Barbara Bertani , Matteo Biagetti , Steven Mark Bromidge , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco , Antonio Kuok, Keong Vong , Simon Edward Ward
发明人： Markus BERGAUER , Barbara Bertani , Matteo Biagetti , Steven Mark Bromidge , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco , Antonio Kuok, Keong Vong , Simon Edward Ward
IPC分类号： C07D401/14 , C07D401/10 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C04B35/632
摘要： Disclosed are methods for the preparation of compounds of formula (I): wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description.
摘要翻译： 公开了制备式（I）化合物的方法：其中R1，m，X，R2，n，W，p，Y，Z，R3，R4，R5和q具有如说明书中定义的含义。
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6.发明授权Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors 失效对5HT1型受体具有亲和力的喹啉和喹唑啉衍生物公开(公告)号：US07592346B2
公开(公告)日：2009-09-22
申请号：US12166547
申请日：2008-07-02
申请人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Mark Bromidge , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco , Antonio Kuok Keong Vong , Simon Edward Ward
发明人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Mark Bromidge , Alessandro Falchi , Colin Philip Leslie , Giancarlo Merlo , Domenica Antonia Pizzi , Marilisa Rinaldi , Luigi Piero Stasi , Jessica Tibasco , Antonio Kuok Keong Vong , Simon Edward Ward
IPC分类号： A61K31/496 , A61K31/517
CPC分类号： C07D401/12 , C04B35/632
摘要： Disclosed are methods for use of compounds of formula (I) in combination with other active substances in the treatment of CNS disorders such as depression or anxiety. wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description.
摘要翻译： 公开的是使用式（I）化合物与其它活性物质组合用于治疗CNS疾病如抑郁症或焦虑症的方法。 其中R1，m，X，R2，n，W，p，Y，Z，R3，R4，R5和q具有如说明书中定义的含义。
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7.发明申请QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS 失效具有5HT1型受体亲和力的喹啉和喹唑啉衍生物公开(公告)号：US20070167423A1
公开(公告)日：2007-07-19
申请号：US11687098
申请日：2007-03-16
申请人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Bromidge , Alessandro Falchi , Colin Leslie , Giancarlo Merlo , Domenica Pizzi , Marilisa Rinaldi , Luigi Stasi , Jessica Tibasco , Antonio Vong , Simon Ward
发明人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Bromidge , Alessandro Falchi , Colin Leslie , Giancarlo Merlo , Domenica Pizzi , Marilisa Rinaldi , Luigi Stasi , Jessica Tibasco , Antonio Vong , Simon Ward
IPC分类号： A61K31/517 , A61K31/496 , C07D403/02 , A61K31/5377 , C07D413/14 , C07D403/14
CPC分类号： C07D401/12 , C04B35/632
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
摘要翻译： 提供式（I）化合物及其药学上可接受的盐：其中R 1，m，X，R 2，n，W，p，Y，Z，R R 3，R 4，R 5和q具有如说明书中定义的含义。 还公开了其治疗方法及其在治疗中的用途，特别是CNS疾病如抑郁或焦虑症。
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8.发明申请Quinoline and quinazoline derivatives having affinity for 5ht1-type receptors 失效对5ht1型受体具有亲和力的喹啉和喹唑啉衍生物公开(公告)号：US20060229312A1
公开(公告)日：2006-10-12
申请号：US10565066
申请日：2004-07-15
申请人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Bromidge , Alessandro Falchi , Colin Leslie , Giancarlo Merlo , Domenica Pizzi , Marilisa Rinaldi , Luigi Stasi , Jessica Tibasco , Antonio Vong , Simon Ward
发明人： Markus Bergauer , Barbara Bertani , Matteo Biagetti , Steven Bromidge , Alessandro Falchi , Colin Leslie , Giancarlo Merlo , Domenica Pizzi , Marilisa Rinaldi , Luigi Stasi , Jessica Tibasco , Antonio Vong , Simon Ward
IPC分类号： A61K31/517 , A61K31/496 , C07D403/02
CPC分类号： C07D401/12 , C04B35/632
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
摘要翻译： 提供式（I）化合物及其药学上可接受的盐：其中R 1，m，X，R 2，n，W，p，Y，Z，R R 3，R 4，R 5和q具有如说明书中所定义的含义。 还公开了其治疗方法及其在治疗中的用途，特别是CNS疾病如抑郁或焦虑症。
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9.发明授权Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors 失效对5HT1型受体具有亲和力的喹啉和喹唑啉衍生物公开(公告)号：US07279481B2
公开(公告)日：2007-10-09
申请号：US10565066
申请日：2004-07-15
IPC分类号： A61K31/496 , C07D401/12 , A61K31/517 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D401/12 , C04B35/632
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
摘要翻译： 提供式（I）化合物及其药学上可接受的盐：其中R 1，m，X，R 2，n，W，p，Y，Z，R R 3，R 4，R 5和q具有如说明书中定义的含义。 还公开了其治疗方法及其在治疗中的用途，特别是CNS疾病如抑郁或焦虑症。
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公开(公告)号：US08168787B2
公开(公告)日：2012-05-01
申请号：US12515105
申请日：2007-11-15
IPC分类号： C07D401/04
CPC分类号： C07D213/58 , C07D213/55 , C07D401/04 , Y02P20/55 , Y02P20/582
摘要： A process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
摘要翻译： 制备4-甲基-N3- [4-（3-吡啶基）-2-嘧啶基] -1,3-苯二胺及其类似物的方法，可用于合成伊马替尼或4 - [（4- 甲基-1-哌嗪基）甲基] -N- [4-甲基-3 - [[4-（3-吡啶基）-2-嘧啶基]氨基]苯基]苯甲酰胺。
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