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1.发明申请公开(公告)号：US20100311688A1
公开(公告)日：2010-12-09
申请号：US12794315
申请日：2010-06-04
IPC分类号： A61K31/717 , A61P27/04
CPC分类号： A61K9/0048 , A61K47/38
摘要： The present invention provides compositions for treating and/or preventing signs and symptoms associated with dry eye and/or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye. Methods of manufacture are also provided.
摘要翻译： 本发明提供用于治疗和/或预防与眼睛和/或眼睛刺激相关的体征和症状的组合物及其使用方法。 这些组合物提供在眼睛滴注中舒适的新型眼用制剂中。 还提供了制造方法。
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2.发明申请Ophthalmic Formulations, Methods Of Manufacture And Methods of Normalizing Meibomian Gland Secretions 审中-公开眼科配方，制造方法和睑板腺分泌物正常化的方法公开(公告)号：US20120093876A1
公开(公告)日：2012-04-19
申请号：US12903881
申请日：2010-10-13
CPC分类号： A61K31/65 , A61K9/0048 , A61K9/14 , A61K47/06
摘要： The present invention provides process for producing non-aqueous compositions for normalizing meibomian gland secretions. The present invention further provides compositions and methods for treating and/or preventing the signs and/or symptoms of dry eye disease.
摘要翻译： 本发明提供了制备用于使睑板腺分泌物正常化的非水性组合物的方法。 本发明还提供了用于治疗和/或预防干眼病症状和/或症状的组合物和方法。
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公开(公告)号：US20080312194A1
公开(公告)日：2008-12-18
申请号：US12074028
申请日：2008-02-28
CPC分类号： A61K31/65 , A61K9/0048 , A61K47/06
摘要： The present invention provides non-aqueous compositions for normalizing meibomian gland secretions, and methods of use thereof. The present invention further provides compositions and methods for treating and/or preventing the signs and/or symptoms of dry eye disease.
摘要翻译： 本发明提供了用于使睑板腺分泌物正常化的非水性组合物及其使用方法。 本发明还提供了用于治疗和/或预防干眼病症状和/或症状的组合物和方法。
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公开(公告)号：US20090010850A1
公开(公告)日：2009-01-08
申请号：US12154665
申请日：2008-05-23
IPC分类号： A61K49/00 , A61K31/407 , A61K31/165 , A61K31/195
CPC分类号： A61K9/0048 , A61K31/407 , A61K47/32 , A61K47/36 , A61K47/38
摘要： The present invention provides compositions for treating and/or preventing signs and symptoms associated with dry eye and/or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye.
摘要翻译： 本发明提供用于治疗和/或预防与眼睛和/或眼睛刺激相关的体征和症状的组合物及其使用方法。 这些组合物提供在眼睛滴注中舒适的新型眼用制剂中。
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公开(公告)号：US20100130580A1
公开(公告)日：2010-05-27
申请号：US12581769
申请日：2009-10-19
IPC分类号： A61K31/407 , A61P27/04
CPC分类号： A61K31/01 , A61K9/0048 , A61K31/045 , A61K31/21 , A61K31/40 , A61K31/715 , A61K47/38
摘要： The present invention provides compositions comprising a low dose amount of an ophthalmic NSAID for treating and/or preventing signs and symptoms associated with dry eye and/or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye and safe for chronic use.
摘要翻译： 本发明提供了包含低剂量的用于治疗和/或预防与眼睛和/或眼睛刺激相关的体征和症状的眼用NSAID的组合物及其使用方法。 这些组合物以新颖的眼科制剂提供，其在眼睛滴注时是舒适的，并且对于慢性使用是安全的。
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公开(公告)号：US06465506B2
公开(公告)日：2002-10-15
申请号：US10080873
申请日：2002-02-22
IPC分类号： A61K31415
CPC分类号： A61K9/0048 , A61K31/00 , A61K31/4178 , A61K31/4409 , Y10S514/912
摘要： The present invention provides methods for instilling an ophthalmic agent. One embodiment of a method according to the invention includes causing a patient to refrain from blinking for at least a specified period of time so as to effect the substantial break down of the patient's tear film covering the patient's eye and instilling an ophthalmic agent to the patient's eye.
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公开(公告)号：US06806364B2
公开(公告)日：2004-10-19
申请号：US10207376
申请日：2002-07-29
IPC分类号： C08L128
CPC分类号： A61K9/0048 , A61K31/198 , A61K31/717 , A61K33/14 , A61K33/22 , A61K33/30 , A61K33/42 , A61K2300/00
摘要： An aqueous ophthalmic solution containing 0.2 to 2.5 percent by weight a polymeric demulcent, 0.045 to 0.065 percent by weight a calcium salt, and 0.14 to 1.4 percent by weight a phosphate salt. The solution has a viscosity of 20 to 150 centipoise and is buffered to a pH 5.5 to 8.5.
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