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公开(公告)号:US06806364B2
公开(公告)日:2004-10-19
申请号:US10207376
申请日:2002-07-29
IPC分类号: C08L128
CPC分类号: A61K9/0048 , A61K31/198 , A61K31/717 , A61K33/14 , A61K33/22 , A61K33/30 , A61K33/42 , A61K2300/00
摘要: An aqueous ophthalmic solution containing 0.2 to 2.5 percent by weight a polymeric demulcent, 0.045 to 0.065 percent by weight a calcium salt, and 0.14 to 1.4 percent by weight a phosphate salt. The solution has a viscosity of 20 to 150 centipoise and is buffered to a pH 5.5 to 8.5.
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公开(公告)号:US09168159B2
公开(公告)日:2015-10-27
申请号:US13128078
申请日:2009-11-04
申请人: Shih-Horng Su , Fuh-Sheng Chen , Debashis Dutta
发明人: Shih-Horng Su , Fuh-Sheng Chen , Debashis Dutta
CPC分类号: A61F2/82 , A61F2/0077 , A61F2/04 , A61F2/06 , A61F2/848 , A61F2002/0081 , A61F2230/0002 , A61F2250/0067 , A61F2250/0068 , A61F2250/0071 , A61K33/00 , A61L2400/12
摘要: Devices and methods for controlling the flaking of coating fragments from medical implants and improving the delivery of therapeutic agents from such coatings are described.
摘要翻译: 描述了用于控制来自医疗植入物的涂层碎片的剥落和改善来自这些涂层的治疗剂的递送的装置和方法。
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公开(公告)号:US20130261733A1
公开(公告)日:2013-10-03
申请号:US13587219
申请日:2012-08-16
申请人: Shih-Horng Su
发明人: Shih-Horng Su
IPC分类号: A61F2/82
CPC分类号: A61F2/88 , A61F2/885 , A61F2/954 , A61F2002/061 , A61F2002/825 , A61F2210/0004 , A61F2230/0067 , A61F2230/0091 , A61F2250/0029 , A61F2250/0039 , A61F2250/0067 , A61F2250/0098
摘要: An expandable, bioabsorbable stent having a coiled-coil configuration is described. The stent further comprises regions of variable pitch that allow for variation in either rigidity, or variability diameter within sub-regions along the length of the deployed stent. By varying the diameter allows the stent to extend into regions such as branched vessels, or into the neck of aneurysms. In some embodiments, the stent comprises longitudinal support fibers that run substantially the length of the deployed stent to provide additional strength. In addition, the stent may also comprise regional support fibers that run less than the length of the stent, and which provide increased regional strength while permitting flexibility of the stent. The stent further comprises micro-tubes that are configured to be visible using medical imaging techniques. The stent can be manufactured from materials that are bioabsorbable and/or include the ability to release pharmacologically active substances over time.
摘要翻译: 描述了具有盘绕线圈结构的可扩张的生物可吸收支架。 支架还包括可变节距的区域,其允许沿着展开的支架的长度的子区域内的刚度或变异性直径的变化。 通过改变直径允许支架延伸到诸如分支血管的区域中,或者延伸到动脉瘤的颈部。 在一些实施例中,支架包括纵向支撑纤维,其基本上延伸展开的支架的长度以提供额外的强度。 此外,支架还可以包括运行小于支架长度的区域支撑纤维,并且在允许支架的柔性的同时提供增加的区域强度。 支架还包括使用医学成像技术构造成可见的微管。 支架可以由生物可吸收的材料和/或包括随时间释放药理活性物质的能力制造。
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公开(公告)号:US08067055B2
公开(公告)日:2011-11-29
申请号:US11690768
申请日:2007-03-23
IPC分类号: A61L33/00
CPC分类号: A61L31/022 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/16 , A61L2300/416 , A61L2300/60
摘要: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.
摘要翻译: 设计用于放置在血管损伤部位,用于抑制现场再狭窄的径向可扩张的血管内支架,使用方法和制造支架的方法。 支架包括由一个或多个金属细丝形成的径向可扩张体,其中长丝的至少一个表面具有粗糙或磨损的表面。 支架可以在研磨表面上包括治疗剂。
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公开(公告)号:US20120029626A1
公开(公告)日:2012-02-02
申请号:US13206697
申请日:2011-08-10
CPC分类号: A61L31/022 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/16 , A61L2300/416 , A61L2300/60
摘要: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.
摘要翻译: 设计用于放置在血管损伤部位,用于抑制现场再狭窄的径向可扩张的血管内支架,使用方法和制造支架的方法。 支架包括由一个或多个金属细丝形成的径向可扩张体,其中长丝的至少一个表面具有粗糙或磨损的表面。 支架可以在研磨表面上包括治疗剂。
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公开(公告)号:US20110301259A1
公开(公告)日:2011-12-08
申请号:US13206430
申请日:2011-08-09
申请人: Shih-Horng Su , John E. Shulze , Debashis Dutta , John Nguyen
发明人: Shih-Horng Su , John E. Shulze , Debashis Dutta , John Nguyen
IPC分类号: A61F2/82
CPC分类号: A61F2/86 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/828 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2002/91566 , A61F2002/91591 , A61F2210/0076 , B29C41/14 , B29C41/34 , B29K2067/046
摘要: A biodegradable polymer stent with radiopacity and a method of making and using a stent with enhanced mechanical strength and/or controlled degradation for use in a bodily lumen is described.
摘要翻译: 描述了具有放射不透性的可生物降解的聚合物支架以及用于制造和使用具有增强的机械强度和/或受控降解的用于体腔的支架的方法。
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公开(公告)号:US20080097568A1
公开(公告)日:2008-04-24
申请号:US11690768
申请日:2007-03-23
IPC分类号: A61F2/06
CPC分类号: A61L31/022 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/16 , A61L2300/416 , A61L2300/60
摘要: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.
摘要翻译: 设计用于放置在血管损伤部位,用于抑制现场再狭窄的径向可扩张的血管内支架,使用方法和制造支架的方法。 支架包括由一个或多个金属细丝形成的径向可扩张体,其中长丝的至少一个表面具有粗糙或磨损的表面。 支架可以在研磨表面上包括治疗剂。
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公开(公告)号:US09173752B2
公开(公告)日:2015-11-03
申请号:US13476336
申请日:2012-05-21
申请人: Shih-Horng Su
发明人: Shih-Horng Su
CPC分类号: A61F2/88 , A61F2/89 , A61F2002/065 , A61F2002/825 , A61F2220/0041 , A61F2230/001
摘要: A bioabsorbable, expandable coil bifurcation stent having a first, second, and third segment, in which the second and third segments are extensions of a coiled fiber in the first segment. Also disclosed is a three-segment expandable coil bifurcation stent in which the second and third segments extend from supporting fibers in the first segment. Further disclosed is an expandable bifurcation stent in which supporting fibers in the first segment also support the second and third segments. The three segments are independently adjustable to fit varied geometries.
摘要翻译: 一种具有第一,第二和第三段的生物可吸收的,可扩张的线圈分叉支架,其中第二和第三段是第一段中的螺旋纤维的延伸。 还公开了三段可扩展线圈分叉支架,其中第二和第三段从第一段中的支撑纤维延伸。 还公开了一种可扩展分叉支架,其中第一段中的支撑纤维还支撑第二和第三段。 这三个部分可独立调整,以适应不同的几何形状。
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公开(公告)号:US08834915B2
公开(公告)日:2014-09-16
申请号:US13435487
申请日:2012-03-30
申请人: Shih-Horng Su , Ting-Bin Yu , Minh Nguyen
发明人: Shih-Horng Su , Ting-Bin Yu , Minh Nguyen
IPC分类号: A61F2/00
CPC分类号: A61K45/06 , A61K9/0019 , A61K9/0024 , A61K9/70 , A61K31/436 , A61K31/496 , A61K31/519 , A61K31/704 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , B29C47/0011 , A61K2300/00 , C08L67/04
摘要: Methods for producing drug-containing bioabsorbable fibers. Also disclosed are methods for treating diseases using a bioabsorbable drug delivery device.
摘要翻译: 生产含药生物可吸收纤维的方法。 还公开了使用生物可吸收药物递送装置治疗疾病的方法。
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公开(公告)号:US20130256928A1
公开(公告)日:2013-10-03
申请号:US13435487
申请日:2012-03-30
申请人: Shih-Horng Su , Ting-Bin Yu , Minh Nguyen
发明人: Shih-Horng Su , Ting-Bin Yu , Minh Nguyen
IPC分类号: B29C47/88
CPC分类号: A61K45/06 , A61K9/0019 , A61K9/0024 , A61K9/70 , A61K31/436 , A61K31/496 , A61K31/519 , A61K31/704 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , B29C47/0011 , A61K2300/00 , C08L67/04
摘要: Methods for producing drug-containing bioabsorbable fibers. Also disclosed are methods for treating diseases using a bioabsorbable drug delivery device.
摘要翻译: 生产含药生物可吸收纤维的方法。 还公开了使用生物可吸收药物递送装置治疗疾病的方法。
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