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公开(公告)号：US07434579B2
公开(公告)日：2008-10-14
申请号：US10984856
申请日：2004-11-10
申请人： Matthew Young , Stuart Kay , Neil Harrison , Ian Darby , Peter Crew , Anne Powell , Cheryl Vanessa Rogerson
发明人： Matthew Young , Stuart Kay , Neil Harrison , Ian Darby , Peter Crew , Anne Powell , Cheryl Vanessa Rogerson
IPC分类号： A61M15/00
CPC分类号： B65D75/327 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0051 , A61M15/006 , A61M15/0086 , A61M15/0091 , A61M15/0096 , A61M15/02 , A61M2202/064 , A61M2206/16
摘要： A dry powder inhaler, including a powder dispersion engine with one or more beads in a dispersion chamber, an airflow path leading into the dispersion chamber, an elongated tape with spaced apart blisters, each blister holding a dose of a dry powder, and blister opening mechanism that sequentially opens the blisters on the elongated tape and releases the dose of each blister into the airflow path.
摘要翻译： 一种干粉吸入器，包括在分散室中具有一个或多个珠子的粉末分散引擎，通向分散室的气流通道，具有间隔开的泡罩的细长带，每个保持一定剂量的干粉末的泡罩和泡罩开口 机构，其顺序地打开细长带上的水泡并将每个泡罩的剂量释放到气流路径中。
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公开(公告)号：US07322354B2
公开(公告)日：2008-01-29
申请号：US10984870
申请日：2004-11-10
申请人： Matthew Young , Stuart Kay , Neil Harrison , Ian Darby , Peter Crew , Anne Powell , Cheryl Vanessa Rogerson
发明人： Matthew Young , Stuart Kay , Neil Harrison , Ian Darby , Peter Crew , Anne Powell , Cheryl Vanessa Rogerson
IPC分类号： A61M5/00
CPC分类号： B65D75/327 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0051 , A61M15/006 , A61M15/0086 , A61M15/0091 , A61M15/0096 , A61M15/02 , A61M2202/064 , A61M2206/16
摘要： A method for operating a dry powder inhaler, the dry powder inhaler having a dose tape having spaced apart doses of a powder pharmaceutical, each dose being in a respective sealed blister. The inhaler includes a breath actuated blister opening system that sequentially opens a blister on the tape. The method involves routing the dose tape between first and second rotating elements; spring biasing the first rotating element to turn in a first direction; holding the first rotating element from rotating against the spring biasing; and releasing the first rotating element, and allowing it to rotate a fraction of one rotation, when air flows adjacent to the first rotating element.
摘要翻译： 一种用于操作干粉吸入器的方法，所述干粉吸入器具有具有间隔剂量的粉末药物的剂量带，每个剂量处于相应的密封泡罩中。 吸入器包括呼吸致动的泡罩开口系统，其顺序地打开带上的泡罩。 该方法包括在第一和第二旋转元件之间布置剂量带; 弹簧偏置第一旋转元件以沿第一方向转动; 保持第一旋转元件抵抗弹簧偏置旋转; 并且当空气相邻于第一旋转元件流动时，释放第一旋转元件，并允许其旋转一分之一转。
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公开(公告)号：US07322353B2
公开(公告)日：2008-01-29
申请号：US10984869
申请日：2004-11-10
申请人： Matthew Young , Stuart Kay , Neil Harrison , Ian Darby , Peter Crew , Anne Powell , Cheryl Vanessa Rogerson
发明人： Matthew Young , Stuart Kay , Neil Harrison , Ian Darby , Peter Crew , Anne Powell , Cheryl Vanessa Rogerson
IPC分类号： A61M5/00
CPC分类号： B65D75/327 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0051 , A61M15/006 , A61M15/0086 , A61M15/0091 , A61M15/0096 , A61M15/02 , A61M2202/064 , A61M2206/16
摘要： A dry powder inhaler, including a housing having an airflow path leading from an inlet, past a powder release location, to a mouthpiece; a drive spool engaged with a capstan adjacent to the powder release location; a spring biasing a ratchet into engagement with the drive spool; and a breath trigger in the airflow path. The breath trigger is moveable from a first position, wherein the breath trigger holds the ratchet, to a second position, wherein the breath trigger releases the ratchet to allow the ratchet to turn the drive spool.
摘要翻译： 一种干粉吸入器，包括具有从入口通过的气流路径经由粉末释放位置到达接口的外壳; 驱动卷轴，其与与粉末释放位置相邻的主导轴接合; 将棘轮偏置成与所述驱动卷轴接合的弹簧; 并在气流路径中进行呼吸触发。 呼吸触发器可从第一位置移动，其中呼吸触发器将棘轮保持到第二位置，其中呼吸触发器释放棘轮以允许棘轮转动驱动卷轴。
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公开(公告)号：US07171965B2
公开(公告)日：2007-02-06
申请号：US10350154
申请日：2003-01-22
申请人： Matthew Young , Stuart Kay , Neil Harrison , Ian Darby , Peter Crew , Anne Powell , Cheryl Vanessa Rogerson
发明人： Matthew Young , Stuart Kay , Neil Harrison , Ian Darby , Peter Crew , Anne Powell , Cheryl Vanessa Rogerson
CPC分类号： B65D75/327 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0051 , A61M15/006 , A61M15/0086 , A61M15/0091 , A61M15/0096 , A61M15/02 , A61M2202/064 , A61M2206/16
摘要： A dose tape for use in a dry powder inhaler has blisters formed in a formpack layer. A lidstock layer is attached over the formpack layer, to seal a dose of dry powder within each of the blisters. A tear strip is attached to the lidstock layer over each of the blisters. Pulling on the tear strip shears out an area of the lidstock over the blister, unsealing the powder contents.
摘要翻译： 用于干粉吸入器的剂量胶带具有形成在包装层中的泡罩。 盖子层附着在成形袋层上，以密封每个泡罩内的一定剂量的干粉。 在每个水疱上的盖子层上附着撕条。 拉动撕裂带将盖子的一个区域剪切出水泡，将粉末内容物开封。
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公开(公告)号：US06966467B2
公开(公告)日：2005-11-22
申请号：US10347092
申请日：2003-01-17
摘要： Valve for an aerosol container for dispensing a suspension of a substance in a liquid propellant contained therein. The valve comprises a valve body (1) having at least one orifice (16) to allow a quantity of the suspension to pass from the container into the valve. The valve further comprises a ring (18) disposed around the valve body (1), the ring being positioned below the at least one orifice to reduce the volume of suspension that can be accommodated within the container below the at least one orifice when the container is orientated with the valve at the bottom, the ring having at least one portion of reduced axial thickness to provide a trough (19) around the valve body below the at least one orifice.
摘要翻译： 用于分配物质在其中包含的液体推进剂中的悬浮液的气溶胶容器的阀。 阀包括具有至少一个孔口（16）的阀体（1），以允许一定数量的悬架从容器进入阀门。 所述阀还包括设置在所述阀体（1）周围的环（18），所述环定位在所述至少一个孔的下方，以减小当所述容器 在阀的底部具有定向，所述环具有减小的轴向厚度的至少一部分，以在所述至少一个孔的下方提供围绕所述阀体的槽（19）。
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公开(公告)号：US07350676B2
公开(公告)日：2008-04-01
申请号：US11107517
申请日：2005-04-15
IPC分类号： B65D83/00
摘要： Valve for an aerosol container for dispensing a suspension of a substance in a liquid propellant contained therein. The valve comprises a valve body (1) having at least one orifice (16) to allow a quantity of the suspension to pass from the container into the valve. The valve further comprises a ring (18) disposed around the valve body (1), the ring being positioned below the at least one orifice to reduce the volume of suspension that can be accommodated within the container below the at least one orifice when the container is orientated with the valve at the bottom, the ring having at least one portion of reduced axial thickness to provide a trough (19) around the valve body below the at least one orifice.
摘要翻译： 用于分配物质在其中包含的液体推进剂中的悬浮液的气溶胶容器的阀。 阀包括具有至少一个孔口（16）的阀体（1），以允许一定数量的悬架从容器进入阀门。 所述阀还包括设置在所述阀体（1）周围的环（18），所述环定位在所述至少一个孔的下方，以减小当所述容器 在阀的底部具有定向，所述环具有减小的轴向厚度的至少一部分，以在所述至少一个孔的下方提供围绕所述阀体的槽（19）。
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公开(公告)号：US06416739B1
公开(公告)日：2002-07-09
申请号：US09582145
申请日：2000-07-20
IPC分类号： A61B800
CPC分类号： A61K9/5052 , A61K9/0073 , A61K49/225 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989
摘要： Microcapsules having a wall thickness of no more than 500 nm, and a bulk density of no more than 0.2 g.cm−3, are suitable for therapeutic or diagnostic use. They are aerodynamically light, and can be used for delivery to the lung, or diagnosis by ultrasound.
摘要翻译： 壁厚不大于500nm，体积密度不超过0.2g·cm-3的微胶囊适用于治疗或诊断用途。 它们在空气动力学上很轻，可用于输送到肺部，或通过超声诊断。
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公开(公告)号：US06510969B2
公开(公告)日：2003-01-28
申请号：US09957916
申请日：2001-09-21
IPC分类号： B65D8354
摘要： Valve for an aerosol container for dispensing a suspension of a substance in a liquid propellant contained therein. The valve comprises a valve body (1) having at least one orifice (16) to allow a quantity of the suspension to pass from the container into the valve. The valve further comprises a ring (18) disposed around the valve body (1), the ring being positioned below the at least one orifice to reduce the volume of suspension that can be accommodated within the container below the at least one orifice when the container is orientated with the valve at the bottom, the ring having at least one portion of reduced axial thickness to provide a trough (19) around the valve body below the at least one orifice.
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公开(公告)号：US06315173B1
公开(公告)日：2001-11-13
申请号：US09709084
申请日：2000-11-10
IPC分类号： B65D8354
摘要： Valve for an aerosol container for dispensing a suspension of a substance in a liquid propellant contained therein The valve comprises a valve body (1) having at least one orifice (16) to allow a quantity of the suspension to pass from the container into the valve. The valve further comprises a ring (18) disposed around the valve body (1), the ring being positioned below the at least one orifice to reduce the volume of suspension that can be accommodated within the container below the at least one orifice when the container is orientated with the valve at the bottom, the ring having at least one portion of reduced axial thickness to provide a trough (19) around the valve body below the at least one orifice.
摘要翻译： 用于将物质悬浮液分配在其中包含的液体推进剂中的气溶胶容器的阀。所述阀包括具有至少一个孔口（16）的阀体（1），以允许一定量的悬浮液从容器通过到阀 。 所述阀还包括设置在所述阀体（1）周围的环（18），所述环定位在所述至少一个孔的下方，以减小当所述容器 在阀的底部具有定向，所述环具有减小的轴向厚度的至少一部分，以在所述至少一个孔的下方提供围绕所述阀体的槽（19）。
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公开(公告)号：US06170717B2
公开(公告)日：2001-01-09
申请号：US09331801
申请日：1999-09-13
IPC分类号： B65D8354
摘要： Valve for an aerosol container for dispensing a suspension of a substance in a liquid propellant contained therein. The valve comprises a valve body (1) having at least one orifice (16) to allow a quantity of the suspension to pass from the container into the valve. The valve further comprises a ring (18) disposed around the valve body (1), the ring being positioned below the at least one orifice to reduce the volume of suspension that can be accommodated within the container below the at least one orifice when the container is orientated with the valve at the bottom, the ring having at least one portion of reduced axial thickness to provide a trough (19) around the valve body below the at least one orifice.
摘要翻译： 用于分配物质在其中包含的液体推进剂中的悬浮液的气溶胶容器的阀。 阀包括具有至少一个孔口（16）的阀体（1），以允许一定数量的悬架从容器进入阀门。 所述阀还包括设置在所述阀体（1）周围的环（18），所述环定位在所述至少一个孔的下方，以减小当所述容器 在阀的底部具有定向，所述环具有减小的轴向厚度的至少一部分，以在所述至少一个孔的下方提供围绕所述阀体的槽（19）。
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