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公开(公告)号：US07534788B2
公开(公告)日：2009-05-19
申请号：US12173888
申请日：2008-07-16
申请人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
发明人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , C07D405/06 , C07D409/06
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中X，A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20100120769A1
公开(公告)日：2010-05-13
申请号：US12690133
申请日：2010-01-20
IPC分类号： A61K31/5377 , C07D241/04 , A61K31/495 , C07D403/02 , A61K31/496 , C07D401/02 , A61P25/00 , C07D413/02
CPC分类号： C07D295/185 , C07D209/08 , C07D209/44 , C07D211/38 , C07D211/46 , C07D213/74 , C07D213/84 , C07D215/08 , C07D217/04 , C07D241/04 , C07D241/20 , C07D243/08 , C07D261/14 , C07D295/215 , C07D309/14
摘要： The present invention relates to compounds of formula I wherein s, R1a and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及其中s，R 1a和R 1至R 3如说明书和权利要求书中所定义的式I化合物及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20090029976A1
公开(公告)日：2009-01-29
申请号：US12173888
申请日：2008-07-16
申请人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
发明人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
IPC分类号： A61K31/541 , C07D417/06 , C07D413/06 , A61K31/5377 , C07D403/06 , A61K31/497 , C07D401/06 , A61K31/4523
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中X，A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20070167436A1
公开(公告)日：2007-07-19
申请号：US11649532
申请日：2007-01-04
IPC分类号： A61K31/496 , A61K31/495 , A61K31/551 , C07D405/02 , C07D243/08 , C07D241/04
CPC分类号： C07D295/185 , C07D209/08 , C07D209/44 , C07D211/38 , C07D211/46 , C07D213/74 , C07D213/84 , C07D215/08 , C07D217/04 , C07D241/04 , C07D241/20 , C07D243/08 , C07D261/14 , C07D295/215 , C07D309/14
摘要： The present invention relates to compounds of formula I wherein s, R1a and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中s，R 1a和R 1至R 3如在说明书和权利要求书中所定义， 及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20090005380A1
公开(公告)日：2009-01-01
申请号：US12136093
申请日：2008-06-10
申请人： Delphine Gaufreteau , Matthias Nettekoven , Jean-Marc Plancher , Olivier Roche , Sebastien Schmitt , Tadakatsu Takahashi
发明人： Delphine Gaufreteau , Matthias Nettekoven , Jean-Marc Plancher , Olivier Roche , Sebastien Schmitt , Tadakatsu Takahashi
IPC分类号： A61K31/5377 , C07D241/04 , A61K31/495 , A61K31/496 , C07D401/02 , C07D413/02
CPC分类号： C07D403/12 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1和R 2如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07544683B2
公开(公告)日：2009-06-09
申请号：US12136093
申请日：2008-06-10
申请人： Delphine Gaufreteau , Matthias Nettekoven , Jean-Marc Plancher , Olivier Roche , Sebastien Schmitt , Tadakatsu Takahashi
发明人： Delphine Gaufreteau , Matthias Nettekoven , Jean-Marc Plancher , Olivier Roche , Sebastien Schmitt , Tadakatsu Takahashi
IPC分类号： A61K31/5377 , A61K31/496 , C07D295/185 , C07D417/12
CPC分类号： C07D403/12 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1和R 2如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07507736B2
公开(公告)日：2009-03-24
申请号：US12019682
申请日：2008-01-25
IPC分类号： A61K31/454 , A61K31/496 , C07D401/12 , C07D451/06
CPC分类号： C07D401/12 , C07D401/02 , C07D401/14 , C07D451/06
摘要： The present invention relates to compounds of formula I wherein A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07388095B2
公开(公告)日：2008-06-17
申请号：US11604563
申请日：2006-11-27
IPC分类号： C07D417/14 , C07D413/14 , C07D401/14
CPC分类号： C07D401/12 , C07D451/06
摘要： The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1至R 4和G如说明书和权利要求及其药学上可接受的盐所定义。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07723325B2
公开(公告)日：2010-05-25
申请号：US12493516
申请日：2009-06-29
IPC分类号： A61K31/4439 , A61K31/5355 , A61K31/541 , C07D295/192 , C07D401/14 , C07D413/14
CPC分类号： C07D401/06 , C07D209/42 , C07D401/14 , C07D403/06 , C07D405/12 , C07D487/04 , C07D491/113
摘要： The present invention relates to compounds of formula I wherein G and R1 to R5 and R12 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中G和R 1至R 5和R 12如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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10.发明授权公开(公告)号：US07648979B2
公开(公告)日：2010-01-19
申请号：US12020637
申请日：2008-01-28
IPC分类号： A61K31/404 , A61P3/04 , C07D401/04 , C07D209/42
CPC分类号： C07D209/42 , C07D401/04 , C07D403/06
摘要： The present invention relates to compounds of formula I wherein A, G and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中A，G和R 1至R 3如说明书和权利要求中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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