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    DIFFUSION DELIVERY SYSTEMS AND METHODS OF FABRICATION
    1.
    发明申请
    DIFFUSION DELIVERY SYSTEMS AND METHODS OF FABRICATION 审中-公开
    扩散输送系统和制造方法

    公开(公告)号：US20120116307A1

    公开(公告)日：2012-05-10

    申请号：US13289177

    申请日：2011-11-04

    申请人： Mauro Ferrari ,  Xuewu Liu ,  Piyush Mohan Sinha ,  Bryan Smith ,  Sadhana Sharma

    发明人： Mauro Ferrari ,  Xuewu Liu ,  Piyush Mohan Sinha ,  Bryan Smith ,  Sadhana Sharma

    IPC分类号： A61M5/00

    CPC分类号： A61K9/0097 ,  A61F2/022 ,  A61M31/002 ,  A61N1/306 ,  B82Y30/00

    摘要： The invention generally relates to diffusion delivery systems and more particularly to high precision nanoengineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.

    摘要翻译： 本发明一般涉及扩散递送系统，更具体地涉及用于治疗应用的高精度纳米工程设备。 该器件包含可在接合的衬底之间制造的扩散区域，该器件可以具有高的机械强度。 本发明还涉及含有扩散递送系统的胶囊。 本发明还涉及制造扩散递送系统的方法。

    Diffusion Delivery Systems and Methods of Fabrication
    2.
    发明申请
    Diffusion Delivery Systems and Methods of Fabrication 审中-公开
    扩散输送系统和制造方法

    公开(公告)号：US20070066138A1

    公开(公告)日：2007-03-22

    申请号：US11278812

    申请日：2006-04-05

    申请人： Mauro Ferrari ,  Xuewu Liu ,  Piyush Sinha ,  Bryan Smith ,  Sadhana Sharma

    发明人： Mauro Ferrari ,  Xuewu Liu ,  Piyush Sinha ,  Bryan Smith ,  Sadhana Sharma

    IPC分类号： H01R13/648

    CPC分类号： A61K9/0097 ,  A61F2/022 ,  A61M31/002 ,  A61N1/306 ,  B82Y30/00

    摘要： The invention generally relates to diffusion delivery systems and more particularly to high precision nanoengineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.

    摘要翻译： 本发明一般涉及扩散递送系统，更具体地涉及用于治疗应用的高精度纳米工程设备。 该器件包含可在接合的衬底之间制造的扩散区域，该器件可以具有高的机械强度。 本发明还涉及含有扩散递送系统的胶囊。 本发明还涉及制造扩散递送系统的方法。

    Porous and non-porous nanostructures
    5.
    发明授权
    Porous and non-porous nanostructures 有权
    多孔和无孔纳米结构

    公开(公告)号：US08568877B2

    公开(公告)日：2013-10-29

    申请号：US13044250

    申请日：2011-03-09

    申请人： Mauro Ferrari ,  Xuewu Liu ,  Ciro Chiappini ,  Jean Raymond Fakhoury

    发明人： Mauro Ferrari ,  Xuewu Liu ,  Ciro Chiappini ,  Jean Raymond Fakhoury

    IPC分类号： H01L21/311

    CPC分类号： H01L29/0665 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L2924/0002 ,  H01L2924/00

    摘要： Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object.

    摘要翻译： 公开了各种微观和纳米尺度的多孔和无孔线状结构。 例如，公开了包括多孔物体的结构，其包括：（i）第一区域; 和（ii）沿所述物体的轴线邻近所述第一区域的第二区域，其中所述第一区域具有与所述第二区域不同的至少一个多孔性质。 还公开了包括：（i）高电阻率硅; 和（ii）基本上垂直于物体轴线的横截面。 还公开了制造和使用这种结构的方法。 例如，本发明提供了制造多孔物体的方法：（i）获得可蚀刻的基底; （ii）在所述基材的表面上形成具有至少一个开口的图案化的赋形金属层; 和（iii）随后将衬底暴露于第一蚀刻溶液和第二蚀刻溶液以分别形成多孔物体的第一区域和第二区域。

    COMBINATORIAL MULTIDOMAIN MESOPOROUS CHIPS AND A METHOD FOR FRACTIONATION, STABILIZATION, AND STORAGE OF BIOMOLECULES
    6.
    发明申请
    COMBINATORIAL MULTIDOMAIN MESOPOROUS CHIPS AND A METHOD FOR FRACTIONATION, STABILIZATION, AND STORAGE OF BIOMOLECULES 有权
    组合多元醇多糖和一种分解，稳定和储存生物分子的方法

    公开(公告)号：US20110065207A1

    公开(公告)日：2011-03-17

    申请号：US12839606

    申请日：2010-07-20

    申请人： Mauro Ferrari ,  Xuewu Liu ,  Ennio Tasciotti ,  Ali Bouamrani ,  Ye Hu

    发明人： Mauro Ferrari ,  Xuewu Liu ,  Ennio Tasciotti ,  Ali Bouamrani ,  Ye Hu

    IPC分类号： G01N33/53 ,  G01N33/00 ,  G01N33/68 ,  H01J49/26 ,  G01N30/02

    CPC分类号： G01N1/405 ,  G01N33/552

    摘要： A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 μl in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity, and in the rational modulation of therapy based on the changes in the protein networks associated with the prognosis and the drug resistance of the disease.

    摘要翻译： 新的分馏装置显示出探索性筛选和生物标志物发现的理想特征。 组成的MSC可以针对所需的孔径和表面性质以及在质量/电荷谱的期望范围内极低的丰富蛋白质和肽的螯合和富集而定制。 MSCs有效地从短至30分钟的时间内将复杂的生物样品中的可重复提取物产生少至10μl。 它们制造成本便宜，并且允许放大生产以获得大量样品的同时处理。 MSCs是复合的，无标记的诊断工具，具有生物识别部分修饰的潜力，以增强特异性。 MSC可以存储，保护和稳定生物液体，从而简化和成本有效地收集和运输临床样品。 基于MSC的装置可以用作补充组织病理学，成像和其他常规临床技术的诊断工具。 MSCs介导的疾病特异性蛋白质特征的鉴定可能有助于个性化治疗组合的选择，治疗功效和毒性的实时评估，以及基于与蛋白质网络相关联的蛋白质网络的变化的合理调节治疗 预后和耐药性的疾病。

    POROUS AND NON-POROUS NANOSTRUCTURES
    9.
    发明申请
    POROUS AND NON-POROUS NANOSTRUCTURES 有权
    多孔和非多孔纳米结构

    公开(公告)号：US20110266521A1

    公开(公告)日：2011-11-03

    申请号：US13044250

    申请日：2011-03-09

    申请人： Mauro Ferrari ,  Xuewu Liu ,  Ciro Chiappini ,  Jean Raymond Fakhoury

    发明人： Mauro Ferrari ,  Xuewu Liu ,  Ciro Chiappini ,  Jean Raymond Fakhoury

    IPC分类号： H01L29/06 ,  H01L21/306 ,  B82Y99/00 ,  B82Y40/00

    CPC分类号： H01L29/0665 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L2924/0002 ,  H01L2924/00

    摘要： Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object.

    摘要翻译： 公开了各种微观和纳米尺度的多孔和无孔线状结构。 例如，公开了包括多孔物体的结构，其包括：（i）第一区域; 和（ii）沿所述物体的轴线邻近所述第一区域的第二区域，其中所述第一区域具有与所述第二区域不同的至少一个多孔性质。 还公开了包括：（i）高电阻率硅; 和（ii）基本上垂直于物体轴线的横截面。 还公开了制造和使用这种结构的方法。 例如，本发明提供了制造多孔物体的方法：（i）获得可蚀刻的基底; （ii）在所述基材的表面上形成具有至少一个开口的图案化的赋形金属层; 和（iii）随后将衬底暴露于第一蚀刻溶液和第二蚀刻溶液以分别形成多孔物体的第一区域和第二区域。