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    Particle compositions with a pre-selected cell internalization mode
    1.
    发明授权
    Particle compositions with a pre-selected cell internalization mode 有权
    具有预选细胞内化模式的粒子组成

    公开(公告)号：US08173115B2

    公开(公告)日：2012-05-08

    申请号：US12181759

    申请日：2008-07-29

    申请人： Paolo Decuzzi ,  Mauro Ferrari

    发明人： Paolo Decuzzi ,  Mauro Ferrari

    IPC分类号： A61K47/48

    CPC分类号： A61K9/10 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/51 ,  A61K47/6911 ,  A61K47/6913 ,  B82Y5/00 ,  Y10S977/904 ,  Y10S977/962

    摘要： A method of formulating a particle composition having a pre-selected cell internalization mode involves selecting a target cell having surface receptors and obtaining particles that have i) surface moieties, that have an affinity for or are capable of binding to the surface receptors of the cell and ii) a preselected shape, where a surface distribution of the surface moieties on the particles and the shape of the particles are effective for the pre-selected cell internalization mode.

    摘要翻译： 配制具有预先选择的细胞内化模式的颗粒组合物的方法包括选择具有表面受体的靶细胞并获得具有i）表面部分的颗粒，其具有与细胞的表面受体的亲和力或能够结合细胞的表面受体 和ii）预选形状，其中颗粒上的表面部分的表面分布和颗粒的形状对于预选的细胞内化模式是有效的。

    INFLAMMATION TARGETING PARTICLES
    3.
    发明申请
    INFLAMMATION TARGETING PARTICLES 审中-公开
    炎症引发颗粒

    公开(公告)号：US20110311452A1

    公开(公告)日：2011-12-22

    申请号：US13141475

    申请日：2008-12-23

    申请人： Mauro Ferrari ,  Rita Serda

    发明人： Mauro Ferrari ,  Rita Serda

    IPC分类号： A61K49/00 ,  A61P35/00 ,  A61P29/00 ,  A61K9/14 ,  A61P9/00 ,  B82Y15/00 ,  B82Y5/00

    CPC分类号： A61K9/1611 ,  A61K9/1676 ,  A61K9/5031 ,  A61K9/5115 ,  Y02A50/423

    摘要： Opsonizable micro- or nanoparticles, that contain at least one active agent, such as an imaging or therapeutic agent; that have a positive surface charge and that do not contain on their surface targeting ligands, such as antibodies, peptides or aptamers, can be used to treating and/or monitoring a condition associated with an inflammation, such as a cytokine stimulated inflammation.

    摘要翻译： 含有至少一种活性剂如成像或治疗剂的可调节的微粒或纳米颗粒; 具有正表面电荷并且不包含在其表面上的靶向配体（例如抗体，肽或适体）可用于治疗和/或监测与炎症相关的病症，例如细胞因子刺激的炎症。

    Folding unit for producing sealed packages of pourable food products
    4.
    发明授权
    Folding unit for producing sealed packages of pourable food products 有权
    用于生产可倾倒食品的密封包装的折叠单元

    公开(公告)号：US07955242B2

    公开(公告)日：2011-06-07

    申请号：US12162717

    申请日：2007-02-26

    申请人： Paolo Fontanazzi ,  Fabrizio Rimondi ,  Massimo Pradelli ,  Giorgio Mattioli ,  Mauro Ferrari

    发明人： Paolo Fontanazzi ,  Fabrizio Rimondi ,  Massimo Pradelli ,  Giorgio Mattioli ,  Mauro Ferrari

    IPC分类号： B65B61/24

    CPC分类号： B65B49/08 ,  B65B51/144

    摘要： A folding unit for producing sealed packages of pourable food products from respective packs, each having a main portion folded into a desired shape, and opposite end portions to be folded to form respective folded ends of a relative finished package. The unit has a first folding station, in turn having a first retaining mechanism for securing each pack by a relative first end portion, and a first folding mechanism for folding a relative second end portion of the pack. The unit also has a second folding station located downstream from the first folding station in the traveling direction of the packs, a second retaining mechanism for securing each pack by the relative folded second end portion, and a second folding mechanism for folding the relative first end portion.

    摘要翻译： 一种折叠单元，用于从相应的包装产生可倾倒食品的密封包装，每个包装具有折叠成所需形状的主要部分和相对的两个端部折叠以形成相对成品包装的折叠端部。 该单元具有第一折叠站，其又具有用于通过相对的第一端部固定每个包装的第一保持机构和用于折叠包装的相对第二端部的第一折叠机构。 该单元还具有在包装的行进方向上位于第一折叠站下游的第二折叠站，用于通过相对折叠的第二端部固定每个包的第二保持机构，以及用于折叠相对第一端部的第二折叠机构 一部分。

    FOLDING UNIT FOR PRODUCING SEALED PACKAGES OF POURABLE FOOD PRODUCTS
    5.
    发明申请
    FOLDING UNIT FOR PRODUCING SEALED PACKAGES OF POURABLE FOOD PRODUCTS 有权
    生产密封食品包装的折叠单元

    公开(公告)号：US20090193763A1

    公开(公告)日：2009-08-06

    申请号：US12162717

    申请日：2007-02-26

    申请人： Paolo Fontanazzi ,  Fabrizio Rimondi ,  Massimo Pradelli ,  Giorgio Mattioli ,  Mauro Ferrari

    发明人： Paolo Fontanazzi ,  Fabrizio Rimondi ,  Massimo Pradelli ,  Giorgio Mattioli ,  Mauro Ferrari

    IPC分类号： B65B43/08

    CPC分类号： B65B49/08 ,  B65B51/144

    摘要： A folding unit for producing sealed packages of pourable food products from respective packs, each having a main portion folded into a desired shape, and opposite end portions to be folded to form respective folded ends of a relative finished package. The unit has a first folding station, in turn having a first retaining mechanism for securing each pack by a relative first end portion, and a first folding mechanism for folding a relative second end portion of the pack. The unit also has a second folding station located downstream from the first folding station in the traveling direction of the packs, a second retaining mechanism for securing each pack by the relative folded second end portion, and a second folding mechanism for folding the relative first end portion.

    摘要翻译： 一种折叠单元，用于从相应的包装产生可倾倒食品的密封包装，每个包装具有折叠成所需形状的主要部分和相对的两个端部折叠以形成相对成品包装的折叠端部。 该单元具有第一折叠站，其又具有用于通过相对的第一端部固定每个包装的第一保持机构和用于折叠包装的相对第二端部的第一折叠机构。 该单元还具有在包装的行进方向上位于第一折叠站下游的第二折叠站，用于通过相对折叠的第二端部固定每个包的第二保持机构，以及用于折叠相对第一端部的第二折叠机构 一部分。

    ENDOCYTOTIC PARTICLES
    6.
    发明申请
    ENDOCYTOTIC PARTICLES 有权
    内毒素颗粒

    公开(公告)号：US20080206344A1

    公开(公告)日：2008-08-28

    申请号：US12034259

    申请日：2008-02-20

    申请人： Paolo DECUZZI ,  Mauro FERRARI

    发明人： Paolo DECUZZI ,  Mauro FERRARI

    IPC分类号： A61K9/14 ,  C12N5/06 ,  A61K33/00 ,  C12Q1/02

    CPC分类号： A61K9/10 ,  A61K9/0019 ,  G01N33/543 ,  G01N33/54346

    摘要： Endocytosis of an active agent into a cell having surface receptors can be enhanced by using particles that have a radius no less than an endocytotic threshold determined based on a surface density of the receptors, a surface density of the moieties and interaction parameters that include at least one of a receptor-moiety spring constant and a non-specific interaction strength.

    摘要翻译： 可以通过使用半径不小于基于受体的表面密度确定的内吞阈值的颗粒，部分的表面密度和相互作用参数至少包括至少包含至少具有表面受体的细胞的活性剂的细胞内吞作用 受体部分弹簧常数和非特异性相互作用强度之一。

    Particles for oral delivery of peptides and proteins
    8.
    发明授权
    Particles for oral delivery of peptides and proteins 有权
    用于口服肽和蛋白质的颗粒

    公开(公告)号：US06355270B1

    公开(公告)日：2002-03-12

    申请号：US09479389

    申请日：2000-01-06

    申请人： Mauro Ferrari ,  Peter J. Dehlinger ,  Francis J. Martin ,  Carl F. Grove ,  David R. Friend

    发明人： Mauro Ferrari ,  Peter J. Dehlinger ,  Francis J. Martin ,  Carl F. Grove ,  David R. Friend

    IPC分类号： A61K914

    CPC分类号： G03F7/00 ,  A61K9/0097 ,  A61K9/1676 ,  A61K9/1694 ,  A61K9/4891

    摘要： Microfabricated, asymmetrical, reservoir-containing particles for use in the oral delivery of biopolymer therapeutic agents such as peptides, proteins and oligonucleotides are disclosed. The particles are encapsulated in enteric-coated capsules or tablets to provide passage through the stomach and release of a suspension of the particles in the intestinal lumen. The particles have a selected shape, and uniform dimensions preferably in the 100 &mgr;m to 1 mm range. The reservoirs open to the face of the particle and are filled with a therapeutic agent and selected excipients. The excipients are selected to delay the dissolution/release of the agent from the particle reservoirs for 5-60 minutes after the particle is released in the intestinal lumen. Alternatively, the pore is plugged with an erodable material. The face of the particle is grafted with a layer of muco-adhesive ligands designed to quickly bind the particle to the intestinal mucosa for several minutes to several hours after release of the particles from the enteric-coated carrier.

    摘要翻译： 公开了用于生物聚合物治疗剂例如肽，蛋白质和寡核苷酸的口服递送的微制造的，不对称的，含储层的颗粒。 将颗粒包封在肠溶衣胶囊或片剂中以提供穿过胃的通道并释放颗粒在肠腔中的悬浮液。 颗粒具有选定的形状，并且尺寸均匀，优选在100μm至1mm范围内。 储存器对颗粒的表面开放并填充有治疗剂和选定的赋形剂。 选择赋形剂以在颗粒在肠腔中释放后延迟药剂从颗粒储存器中溶解/释放5-60分钟。 或者，孔被可侵蚀的材料堵塞。 该颗粒的表面用一层粘膜 - 粘合剂配体接枝，其设计用于在从肠溶衣载体上释放颗粒之后将颗粒快速结合至肠粘膜数分钟至数小时。