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公开(公告)号：US20190240309A1
公开(公告)日：2019-08-08
申请号：US16312189
申请日：2017-06-22
发明人： Peter H. Seeberger , Claney Lebev Pereira , Madhu Emmadi , Sharavathi Guddehalli Parameswarappa , Adam Calow , Petra Menova , Marilda Lisboa , Christopher Martin , Benjamin Schumann , Fei-Fei Xu , Naeem Khan , Paulina Kaplonek , Lennart Lykke
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/6037 , A61K2039/62 , A61P31/04
摘要： The present invention relates to immunogenic compositions comprising a conjugate of a saccharide from Streptococcus pneumoniae serotype 8 and a carrier protein, and a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRM197 carrier protein, or a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a carrier protein, wherein the capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to protein D, the capsular polysaccharide from Streptococcus pneumoniae serotype 18C is conjugated to tetanus toxoid and the capsular polysaccharide from Streptococcus pneumoniae serotype 19F is conjugated to diphtheria toxoid. Said compositions are useful for the prevention and/or treatment of diseases caused by Streptococcus pneumoniae.
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公开(公告)号：US11191822B2
公开(公告)日：2021-12-07
申请号：US16312189
申请日：2017-06-22
发明人： Peter H. Seeberger , Claney Lebev Pereira , Madhu Emmadi , Sharavathi Guddehalli Parameswarappa , Adam Calow , Petra Menova , Marilda Lisboa , Christopher Martin , Benjamin Schumann , Fei-Fei Xu , Naeem Khan , Paulina Kaplonek , Lennart Lykke
摘要： The present invention relates to immunogenic compositions comprising a conjugate of a saccharide from Streptococcus pneumoniae serotype 8 and a carrier protein, and a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRM197 carrier protein, or a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a carrier protein, wherein the capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to protein D, the capsular polysaccharide from Streptococcus pneumoniae serotype 18C is conjugated to tetanus toxoid and the capsular polysaccharide from Streptococcus pneumoniae serotype 19F is conjugated to diphtheria toxoid. Said compositions are useful for the prevention and/or treatment of diseases caused by Streptococcus pneumoniae.
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公开(公告)号：US20190119313A1
公开(公告)日：2019-04-25
申请号：US16094458
申请日：2017-04-18
发明人： Peter H. Seeberger , Claney Lebev Pereira , Sharavathi Guddehalli Parameswarappa , Adam Daniel James Calow , Petra Menova , Ju Yuel Baek
摘要： The present invention relates to the preparation of a synthetic tetrasaccharide, hexasaccharide and octasaccharide representing part of the repeating unit of the Streptococcus pneumoniae type 3 capsular polysaccharide as well as conjugates thereof. Said conjugates are particularly useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically of diseases associated with Streptococcus pneumoniae type 3. The disclosed synthetic method has the huge advantages over the state of the art synthetic methods that intermediate products are crystalline, coupling reaction yields are higher, less reaction steps are required and purification of intermediate products is easier.
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