公开(公告)号：US20210283185A1

公开(公告)日：2021-09-16

申请号：US17257923

申请日：2019-07-03

申请人： Mayo Foundation for Medical Education and Research ,  The Brigham and Women's Hospital, Inc.

发明人： James L. Kirkland ,  Tamar Tchkonia ,  Stefan Tullius ,  Ming Xu ,  Joao Passos

IPC分类号： A61K35/28 ,  A61K31/506 ,  A61K31/353 ,  A01K67/027 ,  A61P39/00

摘要： This document provides methods and materials for treating aging and/or improving transplant outcomes. For example, methods and materials for using one or more senotherapeutic agents to reduce risk of transplant rejection are provided. Non-human animal models for transplant rejection as well as methods for using such non-human animal models to identify agents having the ability to reduce transplant rejection are provided as are non-human animal models for aging and methods for using such non-human animal models to identify agents having the ability to treat aging or the ability to slow the effects of aging.

公开(公告)号：US20220386574A1

公开(公告)日：2022-12-08

申请号：US17831757

申请日：2022-06-03

申请人： Mayo Foundation for Medical Education and Research

发明人： James L. Kirkland ,  Ming Xu ,  Tamar Tchkonia

IPC分类号： A01K67/027 ,  A61K49/00 ,  C07K14/435 ,  C12N15/62

摘要： Transgenic non-human animal models for cellular senescence are provided herein, as are methods and materials for making and using the transgenic non-human animal models. For example, a p21-Cre mouse model for cellular senescence is provided herein.