公开(公告)号：US20240083971A1

公开(公告)日：2024-03-14

申请号：US18234216

申请日：2023-08-15

Applicant: McMaster University

Inventor： Anthony Rullo ,  Yonghong Wan ,  Eden Kapcan ,  Zi Ling Yang

IPC: C07K14/735 ,  A61P35/00 ,  C12N5/078

CPC classification number: C07K14/70535 ,  A61P35/00 ,  C12N5/0634 ,  C12N2510/00

Abstract: The present description relates to covalent immune recruiters (CIRs) comprising an Fc receptor targeting domain (FTD), a covalent binding group (CBG), and a target binding domain (TBD), wherein on binding of the FTD to a cognate Fc receptor, the CBG forms a covalent bond with an amino acid in the Fc receptor. The present description also includes functionalized cells modified by covalent binding of the CIR, methods and uses thereof, for example, methods of functionalizing cells, and methods and uses of such cells for recognition of target cells.