公开(公告)号：US20210276981A1

公开(公告)日：2021-09-09

申请号：US17249332

申请日：2021-02-26

Applicant: McMaster University

Inventor： Anthony Rullo ,  Jonathan Bramson ,  Yonghong Wan ,  Benjamin Lake ,  Nickolas Semiuck

IPC: C07D403/12 ,  C07D493/10 ,  C07D233/90

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies. ABD−(L1)n-ALD-(L2)m-R

公开(公告)号：US20240109870A1

公开(公告)日：2024-04-04

申请号：US18383687

申请日：2023-10-25

Applicant: McMaster University

Inventor： Anthony Rullo ,  Jonathan Bramson ,  Yonghong Wan ,  Benjamin Lake ,  Nickolas Serniuck

IPC: C07D403/12 ,  C07D233/90 ,  C07D493/10

CPC classification number: C07D403/12 ,  C07D233/90 ,  C07D493/10 ,  C07K16/44

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.


ABD-(L1)n-ALD-(L2)m-R  I

公开(公告)号：US11827624B2

公开(公告)日：2023-11-28

申请号：US17249332

申请日：2021-02-26

Applicant: McMaster University

Inventor： Anthony Rullo ,  Benjamin Lake ,  Nickolas Semiuck

IPC: C07D403/12 ,  C07D233/90 ,  C07D493/10 ,  C07K16/44

CPC classification number: C07D403/12 ,  C07D233/90 ,  C07D493/10 ,  C07K16/44

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.

公开(公告)号：US20250101064A1

公开(公告)日：2025-03-27

申请号：US18814979

申请日：2024-08-26

Applicant: McMaster University

Inventor： Anthony Rullo ,  Yonghong Wan ,  Benjamin Lake

IPC: C07K14/00 ,  A61K38/00 ,  C07K5/02 ,  C07K7/06 ,  C07K7/56

Abstract: The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure relates to multivalent antibody recruitment molecules and methods of treating cancer using same.

公开(公告)号：US20240083971A1

公开(公告)日：2024-03-14

申请号：US18234216

申请日：2023-08-15

Applicant: McMaster University

Inventor： Anthony Rullo ,  Yonghong Wan ,  Eden Kapcan ,  Zi Ling Yang

IPC: C07K14/735 ,  A61P35/00 ,  C12N5/078

CPC classification number: C07K14/70535 ,  A61P35/00 ,  C12N5/0634 ,  C12N2510/00

Abstract: The present description relates to covalent immune recruiters (CIRs) comprising an Fc receptor targeting domain (FTD), a covalent binding group (CBG), and a target binding domain (TBD), wherein on binding of the FTD to a cognate Fc receptor, the CBG forms a covalent bond with an amino acid in the Fc receptor. The present description also includes functionalized cells modified by covalent binding of the CIR, methods and uses thereof, for example, methods of functionalizing cells, and methods and uses of such cells for recognition of target cells.