公开(公告)号：US20230158142A1

公开(公告)日：2023-05-25

申请号：US17990480

申请日：2022-11-18

Applicant: McMaster University

Inventor： Yonghong Wan ,  Scott Walsh ,  Nader El-Sayes

IPC: A61K39/395 ,  C12N15/86 ,  A61K39/00 ,  A61P35/00 ,  A61P37/04

CPC classification number: A61K39/3955 ,  C12N15/86 ,  A61K39/0011 ,  A61P35/00 ,  A61P37/04 ,  C12N2760/20222 ,  C12N2760/20234 ,  C12N2760/20243 ,  A61K2039/505 ,  A61K2039/5256

Abstract: The present disclosure relates to a method for stimulating tumor antigen-specific immune responses comprising cancer vaccination involving the blockade or inhibition of interferon signaling. In particular, the method comprises administering an inhibitor of interferon signaling and a cancer vaccine comprising a tumor antigen, wherein the inhibitor of interferon signaling is administered before the cancer vaccine.

公开(公告)号：US20210276981A1

公开(公告)日：2021-09-09

申请号：US17249332

申请日：2021-02-26

Applicant: McMaster University

Inventor： Anthony Rullo ,  Jonathan Bramson ,  Yonghong Wan ,  Benjamin Lake ,  Nickolas Semiuck

IPC: C07D403/12 ,  C07D493/10 ,  C07D233/90

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies. ABD−(L1)n-ALD-(L2)m-R

公开(公告)号：US20190321400A1

公开(公告)日：2019-10-24

申请号：US16312897

申请日：2017-06-23

Applicant: MCMASTER UNIVERSITY

Inventor： Yonghong Wan ,  Scott Walsh ,  Lan Chen ,  Omar Salem ,  Boris Simovic

IPC: A61K35/17 ,  A61K39/00 ,  C12N5/0783 ,  A61P35/00

Abstract: The present invention describes a method for treating cancer comprising adoptive transfer of tumor antigen specific CD8+ T cells and an oncolytic virus vaccine targeting the same antigen.

公开(公告)号：US20250101064A1

公开(公告)日：2025-03-27

申请号：US18814979

申请日：2024-08-26

Applicant: McMaster University

Inventor： Anthony Rullo ,  Yonghong Wan ,  Benjamin Lake

IPC: C07K14/00 ,  A61K38/00 ,  C07K5/02 ,  C07K7/06 ,  C07K7/56

Abstract: The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure relates to multivalent antibody recruitment molecules and methods of treating cancer using same.

公开(公告)号：US20240083971A1

公开(公告)日：2024-03-14

申请号：US18234216

申请日：2023-08-15

Applicant: McMaster University

Inventor： Anthony Rullo ,  Yonghong Wan ,  Eden Kapcan ,  Zi Ling Yang

IPC: C07K14/735 ,  A61P35/00 ,  C12N5/078

CPC classification number: C07K14/70535 ,  A61P35/00 ,  C12N5/0634 ,  C12N2510/00

Abstract: The present description relates to covalent immune recruiters (CIRs) comprising an Fc receptor targeting domain (FTD), a covalent binding group (CBG), and a target binding domain (TBD), wherein on binding of the FTD to a cognate Fc receptor, the CBG forms a covalent bond with an amino acid in the Fc receptor. The present description also includes functionalized cells modified by covalent binding of the CIR, methods and uses thereof, for example, methods of functionalizing cells, and methods and uses of such cells for recognition of target cells.

公开(公告)号：US20240109870A1

公开(公告)日：2024-04-04

申请号：US18383687

申请日：2023-10-25

Applicant: McMaster University

Inventor： Anthony Rullo ,  Jonathan Bramson ,  Yonghong Wan ,  Benjamin Lake ,  Nickolas Serniuck

IPC: C07D403/12 ,  C07D233/90 ,  C07D493/10

CPC classification number: C07D403/12 ,  C07D233/90 ,  C07D493/10 ,  C07K16/44

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.


ABD-(L1)n-ALD-(L2)m-R  I

公开(公告)号：US11045496B2

公开(公告)日：2021-06-29

申请号：US16312897

申请日：2017-06-23

Applicant: MCMASTER UNIVERSITY

Inventor： Yonghong Wan ,  Scott Walsh ,  Lan Chen ,  Omar Salem ,  Boris Simovic

IPC: A61K35/17 ,  A61P35/00 ,  A61K39/00 ,  C12N5/0783

Abstract: The present invention describes a method for treating cancer comprising adoptive transfer of tumor antigen specific CD8+ T cells and an oncolytic virus vaccine targeting the same antigen.