公开(公告)号：US20240150509A1

公开(公告)日：2024-05-09

申请号：US18408005

申请日：2024-01-09

Applicant: McMaster University

Inventor： Sarah Alison Stewart ,  Harald Donald Helmut Stover ,  Michael Bradley Coulson

IPC: C08F222/06 ,  C08F8/34 ,  C08J3/075 ,  C08J3/24

CPC classification number: C08F222/06 ,  C08F8/34 ,  C08J3/075 ,  C08J3/24 ,  C08J2300/14

Abstract: A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized backbone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having biomedical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.

公开(公告)号：US20200148804A1

公开(公告)日：2020-05-14

申请号：US16618252

申请日：2018-05-29

Applicant: McMaster University

Inventor： Sarah Alison Stewart ,  Harald Donald Helmut Stover ,  Michael Bradley Coulson

IPC: C08F222/06 ,  C08J3/075 ,  C08J3/24 ,  C08F8/34

Abstract: A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized back-bone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having bio-medical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.

公开(公告)号：US11873358B2

公开(公告)日：2024-01-16

申请号：US16618252

申请日：2018-05-29

Applicant: McMaster University

Inventor： Sarah Alison Stewart ,  Harald Donald Helmut Stover ,  Michael Bradley Coulson

IPC: C08J3/075 ,  C08J3/24 ,  C08F222/06 ,  C08F8/34

CPC classification number: C08F222/06 ,  C08F8/34 ,  C08J3/075 ,  C08J3/24 ,  C08J2300/14

Abstract: A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized back-bone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having bio-medical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.