公开(公告)号：US20240156972A1

公开(公告)日：2024-05-16

申请号：US18547714

申请日：2022-02-24

Applicant: McMaster University

Inventor： Anthony RULLO ,  Yonghong WAN ,  Harrison McCann ,  Benjamin LAKE

IPC: A61K47/64 ,  A61K35/763 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00 ,  C07K14/005

CPC classification number: A61K47/64 ,  A61K35/763 ,  A61K47/545 ,  A61K47/60 ,  A61P35/00 ,  C07K14/005 ,  C12N2710/16622

Abstract: The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure provides antibody recruitment molecules, pharmaceutical compositions comprising same and kits comprising same. The present disclosure also provides methods of treating cancer using the antibody recruitment molecules in combination with oncolytic virus therapy, and methods for enhancing the efficacy and/or reducing the toxicity of the oncolytic virus therapy.