公开(公告)号：US20240156972A1

公开(公告)日：2024-05-16

申请号：US18547714

申请日：2022-02-24

申请人： McMaster University

发明人： Anthony RULLO ,  Yonghong WAN ,  Harrison McCann ,  Benjamin LAKE

IPC分类号： A61K47/64 ,  A61K35/763 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00 ,  C07K14/005

CPC分类号： A61K47/64 ,  A61K35/763 ,  A61K47/545 ,  A61K47/60 ,  A61P35/00 ,  C07K14/005 ,  C12N2710/16622

摘要： The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure provides antibody recruitment molecules, pharmaceutical compositions comprising same and kits comprising same. The present disclosure also provides methods of treating cancer using the antibody recruitment molecules in combination with oncolytic virus therapy, and methods for enhancing the efficacy and/or reducing the toxicity of the oncolytic virus therapy.

公开(公告)号：US20210338732A1

公开(公告)日：2021-11-04

申请号：US17325557

申请日：2021-05-20

申请人： McMaster University

发明人： Yonghong WAN ,  Scott WALSH ,  Lan CHEN ,  Omar SALEM ,  Boris SIMOVIC

IPC分类号： A61K35/17 ,  A61P35/00 ,  A61K39/00 ,  C12N5/0783

摘要： The present invention describes a method for treating cancer comprising adoptive transfer of tumor antigen specific CD8+ T cells and an oncolytic virus vaccine targeting the same antigen.

公开(公告)号：US20240058383A1

公开(公告)日：2024-02-22

申请号：US18499857

申请日：2023-11-01

申请人： McMaster University

发明人： Yonghong WAN ,  Scott WALSH ,  Lan CHEN ,  Omar SALEM ,  Boris SIMOVIC

IPC分类号： A61K35/17 ,  A61P35/00 ,  A61K39/00 ,  C12N5/0783

CPC分类号： A61K35/17 ,  A61P35/00 ,  A61K39/0011 ,  C12N5/0636 ,  A61K2039/5158 ,  A61K2039/5256 ,  A61K2039/545 ,  C12N2501/2302 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/999

摘要： The present invention describes a method for treating cancer comprising adoptive transfer of tumor antigen specific CD8+ T cells and an oncolytic virus vaccine targeting the same antigen.