公开(公告)号：US20240060940A1

公开(公告)日：2024-02-22

申请号：US18452936

申请日：2023-08-21

Applicant: McMaster University

Inventor： Raja Ghosh

IPC: G01N30/56 ,  B01J20/282

CPC classification number: G01N30/56 ,  B01J20/282 ,  G01N2030/562 ,  G01N2030/521

Abstract: A packing assembly for forming a packed-bed for a chromatography device is described herein. The packing assembly includes a bottom plate and a first top plate. The first top plate has a top plate hole centrally positioned therein. The packing assembly also includes a middle plate. The middle plate has a middle plate hole centrally positioned therein. The middle plate hole is aligned with the top plate hole when the packing assembly is in an assembled state. The packing assembly also includes a second top plate. The second top plate has a protrusion extending outwardly. At least a portion of the protrusion has a same size and a same shape as the top plate hole to be received in the top plate hole when the packing assembly is in a packing state. Methods of packing chromatography media in a packing assembly and assembling a chromatography device are also described herein.

公开(公告)号：US20210039015A1

公开(公告)日：2021-02-11

申请号：US16987845

申请日：2020-08-07

Applicant: McMaster University

Inventor： Raja Ghosh ,  Paul Gatt ,  Umatheny Umatheva ,  Guoqiang Che

IPC: B01D15/22 ,  B01D15/14

Abstract: A chromatography device for removing a solute from a fluid is described herein. The device includes a first plate having an inlet, a first primary channel fluidly coupled to the inlet and a first set of secondary channels fluidly coupled to the first primary channel. The device also includes a middle frame housing chromatographic media and a second plate having an outlet, a second primary channel fluidly coupled to the outlet and a first set of secondary channels fluidly coupled to the second primary channel. The first set of secondary channels directs the fluid in a direction that is transverse to a direction of flow of the fluid through the chromatographic media and the second set of secondary channels directs the fluid to the outlet in a direction that is transverse to the direction of flow of the fluid through the chromatographic media.

公开(公告)号：US10759829B2

公开(公告)日：2020-09-01

申请号：US15616333

申请日：2017-06-07

Applicant: McMaster University

Inventor： Raja Ghosh

IPC: B01D15/18 ,  B01D15/22 ,  B01D15/42 ,  C07K1/18 ,  C07K1/16 ,  C07K1/36 ,  C07K14/76 ,  C07K14/765 ,  C07K14/805 ,  C12N9/36 ,  B01D15/36 ,  B01D15/30 ,  G01N30/52

Abstract: A chromatography device for removing a solute from a fluid is provided. The device has a first plate having an inlet and a first channel. The first channel directs the fluid from the inlet towards chromatographic media housed in a chamber coupled to the first plate. The chamber has a leading edge for receiving the fluid from the first channel and a trailing edge for delivering the fluid to a second channel. The chromatographic media is configured to remove the solute from the fluid as the fluid passes through the chamber. The device also has a second plate coupled to the chamber having the second channel and an outlet. The second channel directs the fluid from the chamber to the outlet. The direction of flow of fluid through the first channel and the second channel is transverse to a direction of flow of the fluid through the chromatographic media. A method of removing a solute from a fluid is also provided.

公开(公告)号：US20170349626A1

公开(公告)日：2017-12-07

申请号：US15616333

申请日：2017-06-07

Applicant: McMaster University

Inventor： Raja Ghosh

IPC: C07K1/18 ,  C07K14/805 ,  C07K14/765 ,  C07K14/76 ,  B01D15/22 ,  C12N9/36 ,  B01D15/18

Abstract: A chromatography device for removing a solute from a fluid is provided. The device has a first plate having an inlet and a first channel. The first channel directs the fluid from the inlet towards chromatographic media housed in a chamber coupled to the first plate. The chamber has a leading edge for receiving the fluid from the first channel and a trailing edge for delivering the fluid to a second channel. The chromatographic media is configured to remove the solute from the fluid as the fluid passes through the chamber. The device also has a second plate coupled to the chamber having the second channel and an outlet. The second channel directs the fluid from the chamber to the outlet. The direction of flow of fluid through the first channel and the second channel is transverse to a direction of flow of the fluid through the chromatographic media. A method of removing a solute from a fluid is also provided.

公开(公告)号：US10758841B2

公开(公告)日：2020-09-01

申请号：US15452157

申请日：2017-03-07

Applicant: McMaster University

Inventor： Raja Ghosh ,  Pedram Madadkar

IPC: B01D15/18 ,  B01D63/08 ,  B01D15/42 ,  B01D15/22 ,  G01N30/60 ,  B01D15/36 ,  B01D15/30 ,  B33Y80/00 ,  G01N30/52

Abstract: A laterally-fed membrane chromatography device for removing a solute from a fluid is provided. The device has a top plate, a middle plate and a bottom plate. The top plate has an inlet and a top channel for directing the fluid from the inlet towards a membrane stack. The middle plate houses the membrane stack. The membrane stack has a leading edge for receiving the fluid from the top channel, a trailing edge for distributing the fluid to the bottom channel, and is configured to remove the solute from the fluid as the fluid passes through the membrane stack. The bottom plate has a bottom channel and an outlet. The bottom channel is for directing the fluid from the membrane stack to the outlet. The top channel directs the fluid form the inlet over the leading edge in a direction that is transverse to the direction of flow of the fluid through the membrane stack.

公开(公告)号：US20180236378A1

公开(公告)日：2018-08-23

申请号：US15947361

申请日：2018-04-06

Applicant: McMaster University

Inventor： Raja Ghosh ,  Pedram Madadkar

IPC: B01D15/18 ,  B01D71/34 ,  B01D15/22 ,  B01D15/30 ,  B01D15/36 ,  B01D15/42 ,  B01D63/08 ,  B01D65/00 ,  G01N30/60 ,  G01N30/52

Abstract: A method of forming a frame around a membrane stack for a laterally-fed membrane chromatography device is provided. The method includes placing a membrane stack having one or more membrane layers on a bottom surface of body of a master mold, the body having opposed side walls and opposed end walls, the opposed side walls spaced apart by a distance greater than a length of the membrane stack, the opposed end walls spaced apart by a distance greater than a width of the membrane stack; placing a cap on the body of the master mold to enclose the membrane stack in the master mold, the cap having at least one opening for injecting a material into a space defined by the end walls of the master mold, the side walls of the master mold, end walls of the membrane stack side walls of the membrane stack, the bottom surface of the body and an inner surface of the cap; injecting the material into the space around the membrane stack; and curing the material to form a frame around the membrane stack.

公开(公告)号：US10758840B2

公开(公告)日：2020-09-01

申请号：US15947361

申请日：2018-04-06

Applicant: McMaster University

Inventor： Raja Ghosh ,  Pedram Madadkar

IPC: B01D15/00 ,  B01D15/22 ,  B01D15/42 ,  B01D65/00 ,  G01N30/60 ,  B01D63/08 ,  B01D71/34 ,  B01D15/30 ,  B01D15/36 ,  G01N30/52 ,  B33Y80/00

Abstract: A method of forming a frame around a membrane stack for a laterally-fed membrane chromatography device is provided. The method includes placing a membrane stack having one or more membrane layers on a bottom surface of body of a master mold, the body having opposed side walls and opposed end walls, the opposed side walls spaced apart by a distance greater than a length of the membrane stack, the opposed end walls spaced apart by a distance greater than a width of the membrane stack; placing a cap on the body of the master mold to enclose the membrane stack in the master mold, the cap having at least one opening for injecting a material into a space defined by the end walls of the master mold, the side walls of the master mold, end walls of the membrane stack side walls of the membrane stack, the bottom surface of the body and an inner surface of the cap; injecting the material into the space around the membrane stack; and curing the material to form a frame around the membrane stack.

公开(公告)号：US20170252672A1

公开(公告)日：2017-09-07

申请号：US15452157

申请日：2017-03-07

Applicant: McMaster University

Inventor： Raja Ghosh ,  Pedram Madadkar

IPC: B01D15/18 ,  B01D65/00 ,  B33Y80/00 ,  B01D15/36 ,  B01D15/42 ,  B01D15/30 ,  B01D63/08 ,  B01D71/34

Abstract: A laterally-fed membrane chromatography device for removing a solute from a fluid is provided. The device has a top plate, a middle plate and a bottom plate. The top plate has an inlet and a top channel for directing the fluid from the inlet towards a membrane stack. The middle plate houses the membrane stack. The membrane stack has a leading edge for receiving the fluid from the top channel, a trailing edge for distributing the fluid to the bottom channel, and is configured to remove the solute from the fluid as the fluid passes through the membrane stack. The bottom plate has a bottom channel and an outlet. The bottom channel is for directing the fluid from the membrane stack to the outlet. The top channel directs the fluid form the inlet over the leading edge in a direction that is transverse to the direction of flow of the fluid through the membrane stack.