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公开(公告)号:US20230233630A1
公开(公告)日:2023-07-27
申请号:US18001828
申请日:2021-07-06
申请人: McMaster University
发明人: Karen Mossman , Maria Davola , Susan Collins , Breanne Cuddington
IPC分类号: A61K35/763 , C07K14/535 , A61K45/06 , C12N7/00
CPC分类号: A61K35/763 , C07K14/535 , A61K45/06 , C12N7/00 , C12N2710/16732 , C12N2710/16722 , C12N2710/16762 , C12N2710/16771
摘要: A recombinant BHV-1 oncolytic virus is provided comprising a BHV-1 mutant with enhanced cancer selectivity and/or enhance immunostimulatory activity as compared to wildtype BHV-1. The BHV-1 mutant is genetically modified to express one or more immunomodulatory molecules that induce an anti-tumor immune response. A method of generating the recombinant BHV-1 oncolytic virus is also provided.