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    Safer attenuated varicella-zoster virus vaccines with missing or diminished latency of infection
    7.
    发明授权
    Safer attenuated varicella-zoster virus vaccines with missing or diminished latency of infection 有权
    更安全的减毒水痘带状疱疹病毒疫苗缺失或减少的潜伏期的感染

    公开(公告)号：US08916175B2

    公开(公告)日：2014-12-23

    申请号：US11630147

    申请日：2005-06-22

    申请人： Jeffrey I. Cohen ,  Edward M. Cox, Jr. ,  Lesley M. Pesnicak

    发明人： Jeffrey I. Cohen ,  Edward M. Cox, Jr. ,  Lesley M. Pesnicak

    IPC分类号： A61K39/25 ,  A01N63/00 ,  C12N7/00 ,  C12N7/04

    CPC分类号： A61K39/25 ,  A61K39/12 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2710/16761 ,  C12N2710/16762

    摘要： Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Insertion of an additional ORF62 gene which is partially truncated with the ORF63 deletion inhibited establishment of latency and allowed normal growth of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety.

    摘要翻译： 描述了具有削弱建立和/或维持延迟的能力及其作为活疫苗的用途的病毒。 疫苗在提供持续病毒复制但抑制潜伏期的基因中具有一个或多个改变。 用于其构建的疫苗材料和方法以水痘带状疱疹病毒为例。 从水痘带状疱疹基因ORF63的两个拷贝中删除重要部分被证明可以抑制病毒活疫苗形式的潜伏感染的建立。 用ORF63缺失部分截断的另外的ORF62基因的插入抑制了潜伏期的建立并允许病毒的正常生长。 其他所需的病毒抗原编码序列和/或细胞因子基因有利地可以代替缺失的遗传物质以增强所需的免疫应答。 该发现的方面涉及其他病毒的活疫苗，并且可以提供具有更高安全性的多种疫苗。

    Bovine Herpes Virus Vaccine With Multiple Mutations
    8.
    发明申请
    Bovine Herpes Virus Vaccine With Multiple Mutations 有权
    牛疱疹病毒疫苗多重突变

    公开(公告)号：US20130034585A1

    公开(公告)日：2013-02-07

    申请号：US13325182

    申请日：2011-12-14

    申请人： SHAFIQUL I. CHOWDHURY ,  HUI YONG WEI

    发明人： SHAFIQUL I. CHOWDHURY ,  HUI YONG WEI

    IPC分类号： A61K39/245 ,  C12N15/63 ,  A61P31/22 ,  C12N7/01

    CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/57 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2710/16762 ,  C12N2710/16771

    摘要： A BHV-1 mutant virus has been made that incorporates into a single virus two or more deletions in one or more of three genes—glycoprotein N, glycoprotein E and Us9. Specifically, a BHV-1 UL49.5Δ30-32 CT-null virus was made and tested. This mutant virus was then used to incorporate additional changes, e.g., the glycoprotein E cytoplasmic-tail deletion, the Us9 deletion, or both. This triple mutant BHV-1 UL49.5Δ30-32 CT-null/gE CTΔ/Us9Δ virus will be superior to the current BHV-1 mutants because the mutant virus will not be shed following reactivation, will be a DIVA based on gE CT-specific serum antibodies, and will induce better protective response by inducing higher SN titers and better cellular immune response. This new virus will have sufficient viral replication in the nasal epithelium and will be a good vaccine for protection of cattle from BHV-1. The new mutant viruses can also be used as vectors for exogenous genes.

    摘要翻译： 已经制备了一种BHV-1突变病毒，其在一个或多个三个基因 - 糖蛋白N，糖蛋白E和Us9中的一个或多个中包含单个病毒两个或多个缺失。 具体来说，制造并测试了BHV-1 UL49.5＆Dgr; 30-32 CT-无效病毒。 然后将该突变型病毒用于引入额外的变化，例如糖蛋白E细胞质尾缺失，Us9缺失或两者。 这种三重突变体BHV-1 UL49.5＆Dgr; 30-32 CT-null / gE CT＆Dgr; / Us9＆Dgr; 病毒将优于目前的BHV-1突变体，因为突变型病毒在再激活后不会脱落，将是基于gE CT特异性血清抗体的DIVA，并通过诱导较高的SN滴度和更好的细胞免疫来诱导更好的保护性反应 响应。 这种新病毒将在鼻上皮中具有足够的病毒复制，并且将是用于保护牛从BHV-1的良好疫苗。 新的突变病毒也可以用作外源基因的载体。

    BOVINE HERPESVIRUS TYPE 1 (BoHV-1) QUADRUPLE GENE DELETED MUTANT
    10.
    发明公开
    BOVINE HERPESVIRUS TYPE 1 (BoHV-1) QUADRUPLE GENE DELETED MUTANT 审中-公开

    公开(公告)号：US20240084325A1

    公开(公告)日：2024-03-14

    申请号：US18268553

    申请日：2021-12-21

    申请人： Shafiqul I. Chowdhury

    发明人： Shafiqul I. Chowdhury

    IPC分类号： C12N15/86 ,  A61K39/12 ,  A61P31/14 ,  C07K14/005

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61P31/14 ,  C07K14/005 ,  A61K2039/552 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2710/16762

    摘要： The invention relates to a Quadruple Gene Deleted Mutant Bovine Herpesvirus Type 1 (BHV-1 QMV) engineered to express protective antigens derived from viruses associated with infection in livestock. The recombinant vector includes a deletion of a cytoplasmic tail of envelope glycoprotein gE (gE-CT), a truncation of glycoprotein gG, a deletion of envelope protein UL49.5 amino acid residues 30-32, and a deletion of UL49.5 cytoplasmic tail amino acid residues 80-96. The truncation of glycoprotein gG comprises a deletion of amino-terminal amino acid residues 1-67. The recombinant vector can include at least two heterologous antigens inserted therein. Included are methods for creating recombinant vectors, mutant viruses, and vaccines for preventing or reducing symptoms associated with viral infection in livestock, in particular bovine respiratory viral infection