公开(公告)号：US10697969B2

公开(公告)日：2020-06-30

申请号：US15192522

申请日：2016-06-24

Applicant: MED-LIFE DISCOVERIES LP

Inventor： Shawn Ritchie ,  Dayan Goodenowe

IPC: G01N33/48 ,  G01N33/50 ,  G01N33/574 ,  G01N33/82

Abstract: The present invention relates to the diagnosis of colorectal and ovarian cancers (CRC and OC, respectively). The present invention describes the relationship between endogenous small molecules and CRC or OC. Specifically, the present invention relates to the diagnosis of CRC and OC through the measurement of vitamin E isoforms and related metabolites. The present invention also relates to diagnostic markers identified in said method. The present invention relates to the underlying case and pre-symptomatic phases of CRC, the diagnosis of various stages and severity of CRC, the early detection of CRC, monitoring and diagnosing the effect of therapy on CRC and OC health states.

公开(公告)号：US10302624B2

公开(公告)日：2019-05-28

申请号：US15143064

申请日：2016-04-29

Applicant: Med-Life Discoveries LP

Inventor： Dayan Goodenowe

IPC: G01N33/92 ,  G01N33/49 ,  G01N33/574 ,  G01N33/68 ,  H01J49/00 ,  H01J49/38

Abstract: The present invention relates to methods for the diagnosis and risk assessment of plasmalogen deficiency mediated diseases of aging. The present invention describes the relationship between plasmalogen biosynthesis dysfunction and the biochemical and clinical manifestations of age related disorders. Specifically the present invention describes an increased prevalence of colon cancer, prostate cancer, lung cancer, breast cancer, ovary cancer, kidney cancer, cognitive impairment and dementia in subjects suffering from adult onset plasmalogen biosynthesis disorder (AO-PBD).