公开(公告)号：US20170114151A1

公开(公告)日：2017-04-27

申请号：US15230893

申请日：2016-08-08

Applicant: MedImmune, LLC ,  MedImmune Limited

Inventor： Nazzareno Dimasi ,  Ryan Fleming ,  Binyam Bezabeh ,  Changshou Gao ,  Antonio Digiandomenico ,  Paul Warrener ,  Charles Stover ,  Bret Sellman ,  Mladen Tomich ,  Reena Varkey ,  Partha S. Chowdhury ,  Ralph Minter ,  Sandrine Guillard ,  Steven Rust ,  Vignesh Venkatraman

IPC: C07K16/46

CPC classification number: C07K16/2863 ,  C07K16/00 ,  C07K16/1214 ,  C07K16/22 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/66 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/94

Abstract: The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making and using such proteins.

公开(公告)号：US09580509B2

公开(公告)日：2017-02-28

申请号：US14356434

申请日：2012-11-06

Applicant: MedImmune, LLC

Inventor： Nazzareno Dimasi ,  Ryan Fleming ,  Binyam Bezabeh ,  Changshou Gao ,  Antonio Digiandomenico ,  Paul Warrener ,  Charles Stover ,  Bret Sellman ,  Mladen Tomich ,  Reena Varkey ,  Partha S. Chowdhury ,  Ralph Minter ,  Sandrine Guillard ,  Steven Rust ,  Vignesh Venkatraman

IPC: C07K16/00 ,  C07K16/12 ,  C07K16/22 ,  C07K16/28 ,  C07K16/46

CPC classification number: C07K16/2863 ,  C07K16/00 ,  C07K16/1214 ,  C07K16/22 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/66 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/94

Abstract: The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making and using such proteins.

Abstract translation: 本公开通常提供结合两个表位（例如，第一和第二表位）的蛋白质，并且二价结合到第一和第二表位中的每一个。 本公开还提供了包含这种蛋白质的组合物，编码这种蛋白质的核酸分子以及制备和使用这些蛋白质的方法。

公开(公告)号：US20150284450A1

公开(公告)日：2015-10-08

申请号：US14440215

申请日：2013-11-06

Applicant: MEDIMMUNE, LLC ,  Medlmmune Limited

Inventor： Antonio Digiandomenico ,  Paul Warrener ,  Charles Stover ,  Bret Sellman ,  Ralph Minter ,  Sandrine Guillard ,  Steven Rust ,  Mladen Tomich ,  Vignesh Venkatraman ,  Reena Varkey ,  Li Peng ,  Melissa Damschroder ,  Partha Chowdhury ,  Nazzareno Dimasi ,  Ryan Fleming ,  Binyam Bezabeh ,  Changshou Gao

IPC: C07K16/12 ,  A61K39/40 ,  A61K45/06

CPC classification number: C07K16/1214 ,  A61K39/40 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: The disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.

Abstract translation: 本公开涉及包含抗Pseudomonas Ps1和PcrV结合分子和相关组合物的组合疗法，用于预防和治疗假单胞菌属感染。

公开(公告)号：US20150023966A1

公开(公告)日：2015-01-22

申请号：US14356500

申请日：2012-11-06

Applicant: MEDIMMUNE, LLC ,  MEDIMMUNE LIMITED

Inventor： Antonio Digiandomenico ,  Paul Warrener ,  Charles Stover ,  Bret Sellman ,  Ralph Minter ,  SAndrine Guillard ,  Steven Rust ,  Mladen Tomich ,  Vignesh Venkatraman ,  Reena Varkey ,  Li Peng ,  Melissa Damschroder ,  Partha Chowdhury ,  Nazzareno Dimasi ,  Ryan Fleming ,  Binyam Bezabeh ,  Changshou Gao ,  Godfrey Rainney ,  Cuihua GAO

IPC: C07K16/12

Abstract: This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.

Abstract translation: 本公开涉及包含抗Pseudomonas Ps1和PcrV结合分子和相关组合物的组合疗法，用于预防和治疗假单胞菌属感染。

公开(公告)号：US10597439B2

公开(公告)日：2020-03-24

申请号：US14356500

申请日：2012-11-06

Applicant: MEDIMMUNE, LLC ,  MEDIMMUNE LIMITED

Inventor： Antonio Digiandomenico ,  Paul Warrener ,  Charles Stover ,  Bret Sellman ,  Ralph Minter ,  Sandrine Guillard ,  Steven Rust ,  Mladen Tomich ,  Vignesh Venkatraman ,  Reena Varkey ,  Li Peng ,  Melissa Damschroder ,  Partha Chowdhury ,  Nazzareno Dimasi ,  Ryan Fleming ,  Binyam Bezabeh ,  Changshou Gao ,  Godfrey Rainey ,  Cuihua Gao

IPC: A61K39/00 ,  C07K16/12 ,  A61P31/04

Abstract: This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.