公开(公告)号：US12018068B2

公开(公告)日：2024-06-25

申请号：US17397474

申请日：2021-08-09

申请人： MedImmune, LLC ,  Humabs BioMed SA

发明人： Qun Wang ,  Charles K. Stover ,  Meghan Pennini ,  Chew-shun Chang ,  Xiaodong Xiao ,  Jamese Hilliard ,  Gilad Kaplan ,  Davide Corti ,  Elisabetta Cameroni ,  Martina Beltramello

IPC分类号： C07K16/12 ,  A61K31/407 ,  A61K38/00 ,  A61K39/00 ,  A61P31/04 ,  C12N15/63

CPC分类号： C07K16/1228 ,  A61P31/04 ,  C12N15/63 ,  A61K31/407 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/734 ,  C07K2317/76

摘要： The present disclosure provides binding proteins (e.g., antibodies or antigen binding fragments thereof) that specifically bind to Klebsiella pneumoniae O1 and induce opsonophagocytic killing of Klebsiella (e.g., Klebsiella pneumoniae). The present disclosure also provides methods of reducing Klebsiella (e.g., Klebsiella pneumoniae) or treating or preventing Klebsiella (e.g., Klebsiella pneumoniae) infection in a subject comprising administering the Klebsiella pneumoniae O1 binding proteins, (e.g., antibodies or antigen-binding fragments thereof) to the subject.

公开(公告)号：US20230079661A1

公开(公告)日：2023-03-16

申请号：US17819199

申请日：2022-08-11

申请人： MedImmune LLC ,  Humabs BioMed SA

发明人： Qun WANG ,  Meghan PENNINI ,  Xiaodong XIAO ,  Davide CORTI ,  Elisabetta CAMERONI ,  Martina BELTRAMELLO ,  Gilad KAPLAN ,  Anna DeMARCO ,  Charles K. Stover

IPC分类号： C07K16/12 ,  A61P31/04 ,  A61K31/407 ,  A61K39/40

摘要： The present disclosure provides binding proteins (e.g., antibodies or antigen binding fragments thereof) that specifically bind to Klebsiella pneumoniae O2 and induce opsonophagocytic killing of Klebsiella (e.g., Klebsiella pneumoniae) and/or protects mice from a lethal Klebsiella challenge. The present disclosure also provides methods of reducing Klebsiella (e.g., Klebsiella pneumoniae) or treating or preventing Klebsiella (e.g., Klebsiella pneumoniae) infection in a subject comprising administering the Klebsiella pneumoniae O2 binding proteins, (e.g., antibodies or antigen-binding fragments thereof) to the subject.

公开(公告)号：US11447542B2

公开(公告)日：2022-09-20

申请号：US16323185

申请日：2017-08-04

申请人： MEDIMMUNE, LLC ,  Humabs BioMed SA

发明人： Qun Wang ,  Charles K. Stover ,  Meghan Pennini ,  Xiaodong Xiao ,  Davide Corti ,  Elisabetta Cameroni ,  Martina Beltramello ,  Gilad Kaplan ,  Anna DeMarco

IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/00 ,  A61K39/40 ,  A61K39/108 ,  C07K16/12 ,  A61P31/04 ,  A61K31/407

摘要： The present disclosure provides binding proteins (e.g., antibodies or antigen binding fragments thereof) that specifically bind to Klebsiella pneumoniae O2 and induce opsonophagocytic killing of Klebsiella (e.g., Klebsiella pneumoniae) and/or protects mice from a lethal Klebsiella challenge. The present disclosure also provides methods of reducing Klebsiella (e.g., Klebsiella pneumoniae) or treating or preventing Klebsiella (e.g., Klebsiella pneumoniae) infection in a subject comprising administering the Klebsiella pneumoniae O2 binding proteins, (e.g., antibodies or antigen-binding fragments thereof) to the subject.

公开(公告)号：US20210238263A1

公开(公告)日：2021-08-05

申请号：US16323185

申请日：2017-08-04

申请人： MEDIMMUNE, LLC ,  Humabs BioMed SA

发明人： Qun Wang ,  Charles K. Stover ,  Meghan Pennini ,  Xiaodong Xiao ,  Davide Corti ,  Elisabetta Cameroni ,  Martina Beltramello ,  Gilad KAPLAN ,  Anna DeMARCO

IPC分类号： C07K16/12 ,  A61P31/04 ,  A61K31/407 ,  A61K39/40

摘要： The present disclosure provides binding proteins (e.g., antibodies or antigen binding fragments thereof) that specifically bind to Klebsiella pneumoniae O2 and induce opsonophagocytic killing of Klebsiella (e.g., Klebsiella pneumoniae) and/or protects mice from a lethal Klebsiella challenge. The present disclosure also provides methods of reducing Klebsiella (e.g., Klebsiella pneumoniae) or treating or preventing Klebsiella (e.g., Klebsiella pneumoniae) infection in a subject comprising administering the Klebsiella pneumoniae O2 binding proteins, (e.g., antibodies or antigen-binding fragments thereof) to the subject.