公开(公告)号：US11759526B2

公开(公告)日：2023-09-19

申请号：US16615582

申请日：2018-05-25

申请人： MedImmune, LLC ,  The Regents Of The University Of California

发明人： Ronald James Christie ,  Changshou Gao ,  Andre Henri St. Amant ,  Javier Read de Alaniz

IPC分类号： A61K47/68 ,  A61K47/69 ,  C07C271/22 ,  C07D207/46

CPC分类号： A61K47/6811 ,  A61K47/6889 ,  A61K47/6923 ,  C07C271/22 ,  C07D207/46 ,  C07C2601/10 ,  C07C2602/50

摘要： The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

公开(公告)号：US20230321267A1

公开(公告)日：2023-10-12

申请号：US18191372

申请日：2023-03-28

申请人： MedImmune, LLC ,  The Regents Of The University Of California

发明人： Ronald James Christie ,  Changshou Gao ,  Andre Henri St. Amant ,  Javier Read de Alaniz

IPC分类号： A61K47/68 ,  A61K47/69 ,  C07C271/22 ,  C07D207/46

CPC分类号： A61K47/6811 ,  A61K47/6889 ,  A61K47/6923 ,  C07C271/22 ,  C07D207/46 ,  C07C2601/10 ,  C07C2602/50

摘要： The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

公开(公告)号：US20200206359A1

公开(公告)日：2020-07-02

申请号：US16615582

申请日：2018-05-25

申请人： MedImmune, LLC ,  The Regents Of The University Of California

发明人： Ronald James Christie ,  Changshou Gao ,  Andre Henri St. Amant ,  Javier Read de Alaniz

IPC分类号： A61K47/68 ,  C07C271/22 ,  C07D207/46 ,  A61K47/69

摘要： The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.