公开(公告)号：US20200306232A1

公开(公告)日：2020-10-01

申请号：US16308672

申请日：2017-06-08

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Carlos Antonio TRINDADE DA SILVA ,  Buce D. HAMMOCK ,  Fawaz G. HAJ ,  Ahmed BETTAIEB ,  Ahmet Bora INCEOGLU

IPC: A61K31/4468 ,  A61P19/08 ,  C12N15/113 ,  A61K9/00

Abstract: Provided are compositions and methods for preventing, mitigating, decreasing, inhibiting and/or reversing bone loss and/or increasing and/or promoting bone regeneration and remodeling and/or preventing, mitigating, decreasing, inhibiting and/or reversing periodontitis and/or periodontal disease in a subject by administering to the subject an effective amount of an inhibitor of soluble epoxide hydrolase (sEH).

公开(公告)号：US10777724B2

公开(公告)日：2020-09-15

申请号：US16049205

申请日：2018-07-30

Applicant: GAS TECHNOLOGY INSTITUTE ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ON BEHALF OF ITS MERCED CAMPUS ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ON BEHALF OF ITS BERKELEY CAMPUS

Inventor： David Cygan ,  Hamid Abbasi ,  Aleksandr Kozlov ,  Roland Winston ,  Eli Yablonovitch

IPC: H01L35/02 ,  H01L31/046 ,  H02S40/22 ,  H02S40/44 ,  F24S23/70

Abstract: A hybrid solar system including a hybrid solar collector using non-imaging optics and photovoltaic components and a heat transfer and storage system in thermal communication with the hybrid solar collector, the heat transfer and storage system using particle laden gas as thermal media to simultaneously generate and store electricity and high temperature dispatchable heat.

公开(公告)号：US20250069520A1

公开(公告)日：2025-02-27

申请号：US18627039

申请日：2024-04-04

Applicant: The Regents of the University of California

Inventor： Adam Gazzaley

IPC: G09B19/00 ,  A61B3/11 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/0533 ,  A61B5/055 ,  A61B5/083 ,  A61B5/11 ,  A61B5/16 ,  A61B5/369 ,  A63B24/00 ,  A63B26/00 ,  A63F13/211 ,  A63F13/213 ,  A63F13/85 ,  G09B7/02

Abstract: Provided are methods that include presenting to a subject an embodied cognitive task that includes a cognitive component and a physical component. The methods further include assessing the subject's performance on each of the cognitive component and the physical component, and adapting the difficulty level of the embodied cognitive task based on the subject's performance on each of the cognitive component and the physical component. In certain aspects, the methods find use in enhancing cognition, physical fitness, or both, in a subject. Also provided are methods of treating and diagnosing cognitive disorders. Systems and computer readable media for practicing the methods of the present disclosure are also provided.

公开(公告)号：US20250064903A1

公开(公告)日：2025-02-27

申请号：US18034622

申请日：2021-10-29

Applicant: University of Washington ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ingrid Swanson PULTZ ,  Clancey WOLF ,  Justin Bloomfield SIEGEL ,  Christine Elaine TINBERG ,  Lance STEWART ,  David BAKER

IPC: A61K38/48 ,  C12N9/52

Abstract: The present disclosure is directed to polypeptides capable of cleaving gluten proteins, e.g., gliadins, nucleic acid molecules encoding the same, pharmaceutical compositions comprising the same, and methods of use thereof for treating celiac sprue disease and/or non-celiac gluten sensitivity (NCGS).

公开(公告)号：US12236688B2

公开(公告)日：2025-02-25

申请号：US17738678

申请日：2022-05-06

Applicant: Toyota Research Institute, Inc. ,  The Regents of the University of California

Inventor： Pavel Tokmakov ,  Allan Jabri ,  Adrien D. Gaidon

IPC: G06V20/58 ,  B60W30/08 ,  G06T7/536

Abstract: A method for tracking occluded objects includes encoding locations of a plurality of objects in an environment, determining a target object, receiving a first end point corresponding to a position of the target object before occlusion behind an occlusion object, distributing a hypothesis between both sides of the occlusion object during occlusion from a subsequent frame of the sequence of frames, receiving a second end point corresponding to a position of the target object after emerging from occlusion from another subsequent frame of the sequence of frames, and determining a trajectory of the target object when occluded by the occlusion object by performing inferences using a spatio-temporal probabilistic graph based on the current frame and the subsequent frames of the sequence of frames. The trajectory of the target object when occluded is used as a learning model for future target objects that are occluded by the occlusion object.

公开(公告)号：US12233407B2

公开(公告)日：2025-02-25

申请号：US18161322

申请日：2023-01-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dino Di Carlo ,  Chueh-Yu Wu

IPC: B01L3/02 ,  B01L3/00 ,  C12N1/04 ,  C12N5/071 ,  C12N5/0783 ,  C12Q1/6806 ,  G01N33/543

Abstract: Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

公开(公告)号：US12233090B2

公开(公告)日：2025-02-25

申请号：US18623246

申请日：2024-04-01

Applicant: The Regents of the University of California ,  Seattle Children's Hospital

Inventor： Yvonne Y. Chen ,  Eugenia Zah ,  Michael C. Jensen

IPC: A61K35/17 ,  A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/46 ,  C12N5/0783 ,  A61K38/00

Abstract: A CD20-OR-CD19 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD20-OR-CD19 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD20-OR-CD19 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

公开(公告)号：US20250059439A1

公开(公告)日：2025-02-20

申请号：US18751011

申请日：2024-06-21

Applicant: The Regents of the University of California

Inventor： Peidong Yang ,  Cheng Zhu ,  Heqing Zhu

IPC: C09K11/08

Abstract: Halide perovskite compounds comprising at least one metal cation, at least one halide anion, and at least one alkali metal-bound crown ether, such as (crown ether@A)2M(IV)X6, (crown ether@A)M(II)X4, or (crown ether@A)M(III)X5 (A=alkali metal cation, M=metal cation, X=halide anion), such as (18C6@K)2HfBr6, (18C6@K)2ZrCl4Br2, (18C6@Ba)MnBr4, and (18C6@Ba)SbCl5 are provided. Methods of generating such halide perovskite compounds are also provided. The halide perovskite compounds provided herein can have improved photoluminescence quantum yield (PLQY), improved tunability, improved purity, and/or improved stability relative to available halide perovskite compounds such as alkali metal cation vacancy-ordered perovskites.

公开(公告)号：US20250059187A1

公开(公告)日：2025-02-20

申请号：US18720571

申请日：2022-12-21

Applicant: The Regents of the University of California

Inventor： Kevan M. Shokat ,  Ziyang Zhang ,  Qinheng Zheng

IPC: C07D471/04 ,  A61K31/519 ,  C07D519/00

Abstract: Described herein, inter alia, are GTPase inhibitors and uses thereof.

公开(公告)号：US12226631B2

公开(公告)日：2025-02-18

申请号：US18141816

申请日：2023-05-01

Applicant: The Regents of The University of California

Inventor： Victor Reggie Edgerton ,  Yuri P. Gerasimenko ,  Nicholas A. Terrafranca ,  Daniel C. Lu

IPC: A61N1/36 ,  A61N1/04

Abstract: A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and/or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and/or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.