公开(公告)号：US20040220546A1

公开(公告)日：2004-11-04

申请号：US10745897

申请日：2003-12-23

申请人： Medtronic, Inc.

发明人： Kenneth T. Heruth ,  Mark S. Lent

IPC分类号： A61M031/00

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M25/007 ,  A61M2025/0007 ,  A61M2025/0057 ,  A61M2025/0073 ,  A61M2202/0464 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/0693 ,  A61M2210/1003

摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc. Methods for treating diseases, including pain and spasticity are also discussed, as well as methods for screening patients and optimizing therapies. In addition, methods for delivering a drug to a brain through a spinal canal are described.

摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 还讨论了治疗疾病，包括疼痛和痉挛症的方法，以及筛选患者和优化疗法的方法。 另外，描述了通过椎管将药物递送到脑的方法。

公开(公告)号：US20040230182A1

公开(公告)日：2004-11-18

申请号：US10745720

申请日：2003-12-23

申请人： Medtronic, Inc.

发明人： Kenneth T. Heruth ,  Mark S. Lent

IPC分类号： A61K009/22

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  A61M2205/3523 ,  A61M2210/0693

摘要： An implantable drug delivery device having a drug releaser that releases a drug from a capsule in the catheter. The drug delivery device includes a reservoir configured to store a drug capsule, a catheter, a pump configured to move the drug capsules into the catheter, and a drug releaser. The drug releaser is connected to the catheter for freeing at least a portion of the drug from one or more of the drug capsules while in the catheter.

摘要翻译： 一种可植入药物递送装置，其具有从导管中的胶囊释放药物的药物释放剂。 药物递送装置包括被配置为存储药物胶囊的储存器，导管，被配置为将药物胶囊移动到导管中的泵以及药物释放器。 药物释放器连接到导管，用于在导管中释放来自一个或多个药物胶囊的至少一部分药物。

公开(公告)号：US20040220548A1

公开(公告)日：2004-11-04

申请号：US10745965

申请日：2003-12-23

申请人： Medtronic, Inc.

发明人： Kenneth T. Heruth ,  Mark S. Lent ,  Justin A. Blanco

IPC分类号： A61M025/00

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M25/007 ,  A61M2025/0007 ,  A61M2025/0057 ,  A61M2025/0073 ,  A61M2202/0464 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/0693 ,  A61M2210/1003

摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc.

摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 等等

公开(公告)号：US20040220545A1

公开(公告)日：2004-11-04

申请号：US10745750

申请日：2003-12-23

申请人： Medtronic, Inc.

发明人： Kenneth T. Heruth ,  Mark S. Lent ,  Justin A. Blanco

IPC分类号： A61M031/00

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M25/007 ,  A61M2025/0007 ,  A61M2025/0057 ,  A61M2025/0073 ,  A61M2202/0464 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/0693 ,  A61M2210/1003

摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc. Methods for treating diseases, including pain and spasticity are also discussed, as well as methods for screening patients and optimizing therapies. In addition, methods for delivering a drug to a brain through a spinal canal are described.

摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 还讨论了治疗疾病，包括疼痛和痉挛症的方法，以及筛选患者和优化疗法的方法。 另外，描述了通过椎管将药物递送到脑的方法。

公开(公告)号：US20040220543A1

公开(公告)日：2004-11-04

申请号：US10745719

申请日：2003-12-23

申请人： Medtronic, Inc.

发明人： Kenneth T. Heruth ,  Mark S. Lent ,  Justin A. Blanco

IPC分类号： A61M031/00

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M25/007 ,  A61M2025/0007 ,  A61M2025/0057 ,  A61M2025/0073 ,  A61M2202/0464 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/0693 ,  A61M2210/1003

摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc. Methods for treating diseases, including pain and spasticity are also discussed, as well as methods for screening patients and optimizing therapies. In addition, methods for delivering a drug to a brain through a spinal canal are described.

摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 还讨论了治疗疾病，包括疼痛和痉挛症的方法，以及筛选患者和优化疗法的方法。 另外，描述了通过椎管将药物递送到脑的方法。

公开(公告)号：US20040220552A1

公开(公告)日：2004-11-04

申请号：US10746269

申请日：2003-12-23

申请人： Medtronic, Inc.

发明人： Kenneth T. Heruth ,  Mark S. Lent ,  Justin A. Blanco

IPC分类号： A61K009/22

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M25/007 ,  A61M2025/0007 ,  A61M2025/0057 ,  A61M2025/0073 ,  A61M2202/0464 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/0693 ,  A61M2210/1003

摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc.

摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 等等

公开(公告)号：US20040220547A1

公开(公告)日：2004-11-04

申请号：US10745919

申请日：2003-12-23

申请人： Medtronic, Inc

发明人： Kenneth T. Heruth ,  Mark S. Lent ,  Justin A. Blanco

IPC分类号： A61M025/00

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M25/007 ,  A61M2025/0007 ,  A61M2025/0057 ,  A61M2025/0073 ,  A61M2202/0464 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/0693 ,  A61M2210/1003

摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc.

摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 等等

公开(公告)号：US20040220544A1

公开(公告)日：2004-11-04

申请号：US10745731

申请日：2003-12-23

申请人： Medtronic, Inc.

发明人： Kenneth T. Heruth ,  Mark S. Lent

IPC分类号： A61M031/00

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M25/007 ,  A61M2025/0007 ,  A61M2025/0057 ,  A61M2025/0073 ,  A61M2202/0464 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/0693 ,  A61M2210/1003

摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc. Methods for treating diseases, including pain and spasticity are also discussed, as well as methods for screening patients and optimizing therapies. In addition, methods for delivering a drug to a brain through a spinal canal are described.

摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 还讨论了治疗疾病，包括疼痛和痉挛症的方法，以及筛选患者和优化疗法的方法。 另外，描述了通过椎管将药物递送到脑的方法。

公开(公告)号：US20040220518A1

公开(公告)日：2004-11-04

申请号：US10745963

申请日：2003-12-23

申请人： Medtronic, Inc.

发明人： Kenneth T. Heruth ,  Mark S. Lent ,  Justin A. Blanco

IPC分类号： A61M037/00

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M25/007 ,  A61M2025/0007 ,  A61M2025/0057 ,  A61M2025/0073 ,  A61M2202/0464 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/0693 ,  A61M2210/1003

摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc.

摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 等等