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公开(公告)号：US20230053149A1
公开(公告)日：2023-02-16
申请号：US17814405
申请日：2022-07-22
发明人： Nicolas Coulombe , Rachid Mahrouche , Louis Jacob , Dan Wittenberger , Martin Lacharite , Jean-Pierre Lalonde
摘要： A method of ablating tissue includes positioning a treatment device proximate to a target tissue area. The treatment device has an expandable treatment element. The expandable treatment element is inflated with a refrigerant during an inflation phase such that at least a portion of the expandable treatment element is in contact with the target tissue area. A first pressure measurement of the inflated expandable treatment element is recorded and compared to a predetermined pressure threshold. The refrigerant is circulated within the expandable treatment element during an ablation phase to reduce a temperature of the target tissue area to a temperature sufficient to cryoablate the target tissue area. A second pressure measurement of the expandable treatment element is recorded during the ablation phase and compared to the predetermined pressure threshold.
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公开(公告)号：US11357563B2
公开(公告)日：2022-06-14
申请号：US15784853
申请日：2017-10-16
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system may include controller that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.
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公开(公告)号：US10888367B2
公开(公告)日：2021-01-12
申请号：US15922510
申请日：2018-03-15
发明人： Rachid Mahrouche , Dan Wittenberger
摘要： A system and method for providing greater control over the temperature of a thermal treatment element of a medical device, enabling an operator to extend a thawing period of a cryoablation procedure. The system may include a fluid flow path that bypasses a subcooler, giving the operator selective control over the temperature of refrigerant delivered to the treatment element and, therefore, treatment element temperature. Additionally or alternatively, the system may include a fluid delivery conduit that is in communication with a liquid refrigerant and a gaseous refrigerant. Adjustment of the ratio of liquid to gaseous refrigerant also offers control over the treatment element temperature. Additionally or alternatively, the system may include one or more valves and/or heating elements in the fluid delivery and recovery conduits to control the treatment element temperature.
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公开(公告)号：US09956024B2
公开(公告)日：2018-05-01
申请号：US14329571
申请日：2014-07-11
发明人： Rachid Mahrouche , Dan Wittenberger
CPC分类号： A61B18/02 , A61B2018/00011 , A61B2018/00017 , A61B2018/00023 , A61B2018/00041 , A61B2018/0022 , A61B2018/00577 , A61B2018/0212 , A61B2018/0268
摘要： A system and method for providing greater control over the temperature of a thermal treatment element of a medical device, enabling an operator to extend a thawing period of a cryoablation procedure. The system may include a fluid flow path that bypasses a subcooler, giving the operator selective control over the temperature of refrigerant delivered to the treatment element and, therefore, treatment element temperature. Additionally or alternatively, the system may include a fluid delivery conduit that is in communication with a liquid refrigerant and a gaseous refrigerant. Adjustment of the ratio of liquid to gaseous refrigerant also offers control over the treatment element temperature. Additionally or alternatively, the system may include one or more valves and/or heating elements in the fluid delivery and recovery conduits to control the treatment element temperature.
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公开(公告)号：US20210369322A1
公开(公告)日：2021-12-02
申请号：US17404248
申请日：2021-08-17
摘要： An adapter for putting two incompatible medical systems in fluid communication with each other. The adapter may have a continuous outer diameter and may include two segments: a first segment composed of a rigid material and including a first portion and a second portion, the first portion having a continuous outer diameter and the second portion defining one or more flanges, the first segment defining a first passage therethrough; and a second segment composed of a flexible material and coupled to the first segment, including a first portion and a second portion. The first portion of the second segment may have an inner surface configured to surround the flanges of the second portion of the first segment, and the second portion of the second segment having a tapered inner surface, the second segment defining a second passage therethrough that is continuous with the first passage.
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公开(公告)号：US11123126B2
公开(公告)日：2021-09-21
申请号：US16593298
申请日：2019-10-04
摘要： An adapter for putting two incompatible medical systems in fluid communication with each other. The adapter may have a continuous outer diameter and may include two segments: a first segment composed of a rigid material and including a first portion and a second portion, the first portion having a continuous outer diameter and the second portion defining one or more flanges, the first segment defining a first passage therethrough; and a second segment composed of a flexible material and coupled to the first segment, including a first portion and a second portion. The first portion of the second segment may have an inner surface configured to surround the flanges of the second portion of the first segment, and the second portion of the second segment having a tapered inner surface, the second segment defining a second passage therethrough that is continuous with the first passage.
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公开(公告)号：US10952791B2
公开(公告)日：2021-03-23
申请号：US15842323
申请日：2017-12-14
发明人： Dan Wittenberger , Rachid Mahrouche
摘要： A medical system, comprising an ablation catheter is disclosed. The ablation catheter includes an elongate shaft with a proximal end, a distal end and a lumen disposed between the proximal end and the distal end. The ablation catheter also includes an expandable element in fluid communication with the lumen, a first temperature sensor operable to measure a first temperature; and a second temperature sensor operable to measure a second temperature. The first temperature sensor and the second temperature sensor are longitudinally separated from each other by at least a portion of the expandable element.
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公开(公告)号：US09993280B2
公开(公告)日：2018-06-12
申请号：US14790465
申请日：2015-07-02
发明人： Rachid Mahrouche , Eric Monger
CPC分类号： A61B18/02 , A61F2007/0056 , A61F2007/0095 , C09K5/041 , F04B37/00 , F25B1/00 , F25B3/00 , F25B13/00
摘要： A system and method of using a source of low-pressure refrigerant for a cryotherapy procedure. The system may generally include a fluid reservoir and a fluid flow path in thermal exchange with the fluid reservoir, the fluid flow path including a thermal exchange device in thermal exchange with the fluid reservoir, a compressor in fluid communication with the thermal exchange device, a condenser, a reversing valve located between the compressor and the condenser, and an expansion valve located between the condenser and the thermal exchange device. The method may include transferring a low-pressure refrigerant to a first fluid reservoir, reducing the temperature of the refrigerant within the first fluid reservoir, increasing the temperature of the refrigerant within the first fluid reservoir, and transferring the pressurized refrigerant from the first fluid reservoir to a second fluid reservoir.
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9.发明授权公开(公告)号：US09084590B2
公开(公告)日：2015-07-21
申请号：US13803450
申请日：2013-03-14
发明人： Dan Wittenberger , Rachid Mahrouche
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00791 , A61B2018/00863 , A61B2018/0212
摘要： A method and system for improved lesion creation. The method generally includes positioning a treatment element of a medical device proximate an area of target tissue and operating a control unit in accordance with a duty cycle, that includes at least one freeze-warm cycle, each freeze-warm cycle including: supplying coolant to the treatment element at a first flow rate that causes the treatment element to reach a first temperature, the first temperature causing ablation of the target tissue and cryoadhesion between the treatment element and target tissue, and supplying coolant to the treatment element at a second flow rate that causes the treatment element to reach a second temperature, the second temperature being higher than the first temperature and the second flow rate being lower than the first flow rate, the second temperature being above a temperature at which ablation occurs and below a temperature at which cryoadhesion is broken.
摘要翻译： 一种改善病变创造的方法和系统。 该方法通常包括将医疗装置的治疗元件定位在目标组织的区域附近并根据占空比操作控制单元，该占空比包括至少一个冷冻循环，每个冷冻循环包括：将冷却剂供应到 所述处理元件以使得所述处理元件达到第一温度的第一流速，所述第一温度引起所述靶组织的消融和所述处理元件与所述目标组织之间的冷冻粘附，以及以第二流量向所述处理元件供应冷却剂 使得处理元件达到第二温度，第二温度高于第一温度，第二流量低于第一流量，第二温度高于消融发生的温度且低于第一温度， 冷冻粘连破裂。
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公开(公告)号：US11607262B2
公开(公告)日：2023-03-21
申请号：US16869703
申请日：2020-05-08
发明人： Rachid Mahrouche , Eric Monger
摘要： A system and method of using a source of low-pressure refrigerant for a cryotherapy procedure. The system may generally include a fluid reservoir and a fluid flow path in thermal exchange with the fluid reservoir, the fluid flow path including a thermal exchange device in thermal exchange with the fluid reservoir, a compressor in fluid communication with the thermal exchange device, a condenser, a reversing valve located between the compressor and the condenser, and an expansion valve located between the condenser and the thermal exchange device. The method may include transferring a low-pressure refrigerant to a first fluid reservoir, reducing the temperature of the refrigerant within the first fluid reservoir, increasing the temperature of the refrigerant within the first fluid reservoir, and transferring the pressurized refrigerant from the first fluid reservoir to a second fluid reservoir.
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