公开(公告)号：US20120286156A1

公开(公告)日：2012-11-15

申请号：US13474009

申请日：2012-05-17

申请人： Melvin Andrew PARK ,  Desmond Allen KAPLAN ,  Mark RIDGEWAY

发明人： Melvin Andrew PARK ,  Desmond Allen KAPLAN ,  Mark RIDGEWAY

IPC分类号： H01J3/26 ,  H01J49/26

CPC分类号： G01N27/622

摘要： Ions with a predetermined ion mobility range are produced by filtering ions entrained in a stream of moving gas with two ion mobility low pass filters located consecutively in the gas stream. Each filter is formed by applying a DC electric field to the gas stream which causes the ions to move in a direction opposite to the gas flow. Ions are collected between the two filters and transferred to a detector or analyzing device. In one embodiment, the maximum field strength of the electric field barrier in the first ion mobility low pass filter is continued as a plateau of essentially constant field strength up to the electric field barrier in the second ion mobility low pass filter, which has a maximum field strength higher that the maximum field strength of the electric field barrier in the first ion mobility low pass filter.

摘要翻译： 具有预定离子迁移率范围的离子通过在气流中连续排列两个离子迁移率低通过滤器来过滤夹带在移动气体流中的离子而产生。 每个过滤器通过向气流施加DC电场而形成，其导致离子沿与气流相反的方向移动。 离子在两个过滤器之间收集并转移到检测器或分析装置。 在一个实施例中，第一离子迁移率低通滤波器中的电场势垒的最大场强作为基本上恒定场强的平台直到第二离子迁移率低通滤波器中的电场势垒持续，其具有最大值 场强比第一离子迁移率低通滤波器中的电场势垒的最大场强高。

公开(公告)号：US20120298860A1

公开(公告)日：2012-11-29

申请号：US13115424

申请日：2011-05-25

申请人： Melvin Andrew PARK ,  Desmond Allen KAPLAN ,  Mark RIDGEWAY ,  Gary L. GLISH

发明人： Melvin Andrew PARK ,  Desmond Allen KAPLAN ,  Mark RIDGEWAY ,  Gary L. GLISH

IPC分类号： H01J49/26 ,  B23P11/00

CPC分类号： G01N27/624 ,  H01J49/0404 ,  Y10T29/49826

摘要： Analyte ions are analyzed first by field asymmetric ion mobility spectrometry (FAIMS) before being analyzed by a mass analyzer. Analyte ions are produced at near atmospheric pressure and transferred via a dielectric capillary into the vacuum system of the mass analyzer. While passing through the capillary, the ions are analyzed by FAIMS via electrodes on the interior wall of the capillary. Improved ion transmission is achieved by providing smooth geometric transitions between the channel in FAIMS analyzer and the channel in the remainder of the capillary.

摘要翻译： 首先通过场不对称离子迁移谱（FAIMS）分析分析离子，然后通过质谱仪进行分析。 分析离子在接近大气压下产生，并通过介电毛细管转移到质量分析仪的真空系统中。 当通过毛细管时，通过FAIMS通过毛细管内壁上的电极分析离子。 通过在FAIMS分析仪中的通道和毛细管剩余部分中的通道之间提供平滑的几何过渡来实现改进的离子透过。