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公开(公告)号：US10577316B2
公开(公告)日：2020-03-03
申请号：US15715493
申请日：2017-09-26
发明人： John Y. L. Chung , Kevin Campos , Edward Cleator , Robert F. Dunn , Andrew Gibson , R Scott Hoerrner , Stephen Keen , Dave Lieberman , Zhuqing Liu , Joseph Lynch , Kevin M. Maloney , Feng Xu , Nobuyoshi Yasuda , Naoki Yoshikawa , Yong-Li Zhong
IPC分类号： C07D207/09 , C07D207/08 , C12P17/10
摘要： The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions:
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公开(公告)号：US10087189B2
公开(公告)日：2018-10-02
申请号：US15808740
申请日：2017-11-09
发明人： John Y. L. Chung , Kevin Campos , Edward Cleator , Robert F. Dunn , Andrew Gibson , R. Scott Hoerrner , Stephen Keen , Dave Lieberman , Zhuqing Liu , Joseph Lynch , Kevin M. Maloney , Feng Xu , Nobuyoshi Yasuda , Naoki Yoshikawa , Yong-Li Zhong
IPC分类号： C07D487/04 , C07D263/06 , C07D207/09 , C07D403/12 , A61K31/4196 , A61K31/519
摘要： The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.
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公开(公告)号：US10053466B2
公开(公告)日：2018-08-21
申请号：US15831895
申请日：2017-12-05
发明人： John Y. L. Chung , Feng Peng , Yonggang Chen , Amude Mahmoud Kassim , Cheng-yi Chen , Mathew Maust , Mark McLaughlin , Michael J. Zacuto , Qinghao Chen , Lushi Tan , Zhiguo Jake Song , Yang Cao , Feng Xu
IPC分类号： C07D487/04 , A61K31/4162
摘要： A process for preparing a compound of structural Formula Ia: comprising Boc deprotection with TFA of: and reductive amination of:
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公开(公告)号：US20150197490A1
公开(公告)日：2015-07-16
申请号：US14669303
申请日：2015-03-26
IPC分类号： C07D209/18
CPC分类号： C07D209/18 , C07B2200/13
摘要： The present invention relates to polymorphic forms of a compound of formula A: This compound is useful as a glucagon receptor antagonist and serves as a pharmaceutically active ingredient for the treatment of type 2 diabetes and related conditions, such as hyperglycemia, obesity, dyslipidemia, and the metabolic syndrome. Hydrates, hemihydrates, anhydrates and similar polymorphic forms are included.
摘要翻译： 本发明涉及式A化合物的多晶型物质：该化合物可用作胰高血糖素受体拮抗剂并用作用于治疗2型糖尿病和相关病症的药物活性成分，例如高血糖症，肥胖症，血脂异常和 代谢综合征。 包括水合物，半水合物，水合物和类似的多晶型物质。
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公开(公告)号：US20140171480A1
公开(公告)日：2014-06-19
申请号：US14186829
申请日：2014-02-21
发明人： John Y. L. Chung , Yanfeng Zhang , Laura Artino , Aaron S. Cote , Donal Desmond , Jeremy Scott , Yekaterina Vaynshteyn
IPC分类号： C07D209/18
CPC分类号： C07D209/18 , C07B2200/13
摘要： The present invention relates to polymorphic forms of a compound of formula A: This compound is useful as a glucagon receptor antagonist and serves as a pharmaceutically active ingredient for the treatment of type 2 diabetes and related conditions, such as hyperglycemia, obesity, dyslipidemia, and the metabolic syndrome. Hydrates, hemihydrates, anhydrates and similar polymorphic forms are included.
摘要翻译： 本发明涉及式A化合物的多晶型物质：该化合物可用作胰高血糖素受体拮抗剂并用作用于治疗2型糖尿病和相关病症的药物活性成分，例如高血糖症，肥胖症，血脂异常和 代谢综合征。 包括水合物，半水合物，水合物和类似的多晶型物质。
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公开(公告)号：US11124478B2
公开(公告)日：2021-09-21
申请号：US16795745
申请日：2020-02-20
发明人： John Y. L. Chung , Kevin Campos , Edward Cleator , Robert F. Dunn , Andrew Gibson , R. Scott Hoerrner , Stephen Keen , Dave Lieberman , Zhuqing Liu , Joseph Lynch , Kevin M. Maloney , Feng Xu , Nobuyoshi Yasuda , Naoki Yoshikawa , Yong-Li Zhong
IPC分类号： C07D207/09 , C07D207/08 , C12P17/10
摘要： The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions:
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7.发明申请公开(公告)号：US20190055216A1
公开(公告)日：2019-02-21
申请号：US16074141
申请日：2017-01-30
发明人： Aaron M. Dumas , Jeremy P. Scott , Michael Shevlin , Zhijian Liu , John Y. L. Chung , Feng Yu , Dongfang Meng
IPC分类号： C07D401/12 , C07D211/78 , C07C249/08 , C07C251/38
摘要： The present invention relates to processes for the preparation of N-protected 4-((2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylates. Such compounds have application in the preparation of beta-lactamase inhibitors such as 7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamides and esters, in particular, the beta lactamase inhibitor, (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide. The present invention also encompasses intermediates useful in the disclosed processes and methods for their preparation.
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公开(公告)号：US09809536B2
公开(公告)日：2017-11-07
申请号：US14354161
申请日：2012-10-22
发明人： John Y. L. Chung , Kevin Campos , Edward Cleator , Robert F. Dunn , Andrew Gibson , R Scott Hoerrner , Stephen Keen , Dave Lieberman , Zhuqing Liu , Joseph Lynch , Kevin M. Maloney , Feng Xu , Nobuyoshi Yasuda , Naoki Yoshikawa , Yong-Li Zhong
IPC分类号： C07D207/09 , C07D207/08 , C12P17/10
CPC分类号： C07D207/09 , C07D207/08 , C12P17/10
摘要： The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions.
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公开(公告)号：US20170158701A1
公开(公告)日：2017-06-08
申请号：US15325100
申请日：2015-07-16
发明人： John Y. L. Chung , Feng Peng , Yonggang Chen , Amude Mahmoud Kassim , Cheng-yi Chen , Mathew Maust , Mark McLaughlin , Michael J. Zacuto , Qinghao Chen , Lushi Tan , Zhiguo Jake Song , Yang Cao , Feng Xu
IPC分类号： C07D487/04 , A61K31/4162
CPC分类号： C07D487/04 , A61K31/4162 , C07D309/30
摘要： A process for preparing a compound of structural Formula Ia: comprising Boc deprotection with TFA of, reductive amination of:
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公开(公告)号：US10899771B2
公开(公告)日：2021-01-26
申请号：US16590180
申请日：2019-10-01
发明人： John Y. L. Chung , Kevin Campos , Edward Cleator , Robert F. Dunn , Andrew Gibson , R. Scott Hoerrner , Stephen Keen , Dave Lieberman , Zhuqing Liu , Joseph Lynch , Kevin M. Maloney , Feng Xu , Nobuyoshi Yasuda , Naoki Yoshikawa , Yong-Li Zhong
IPC分类号： C07D487/04 , C07D403/12 , C07D207/09 , C07D263/06 , A61K31/4196 , A61K31/519
摘要： The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.
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