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公开(公告)号：US20200261421A1
公开(公告)日：2020-08-20
申请号：US16461952
申请日：2017-12-19
Applicant: Merck Sharp & Dohme Corp.
Inventor： Brian McKittrick , John P. Caldwell , John A. McCauley , Henry Vaccaro , Tin-Yau Chan , Hyunjin Kim , Elizabeth Smith , Liwu Hong , Tanweer Khan , Shihong Ying , Hongwu Wang
IPC: A61K31/4168 , A61K45/06 , A61K31/497 , C07D233/72 , C07D403/12 , C07D401/12 , A61P31/18
Abstract: The present invention is directed to compounds of Formula I, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
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公开(公告)号：US20200069691A1
公开(公告)日：2020-03-05
申请号：US16461899
申请日：2017-12-19
Applicant: Merck Sharp & Dohme Corp.
Inventor： Brian McKittrick , John P. Caldwell , John McCauley , Henry Vaccaro , Tin-Yau Chan , Hyunjin Kim , Elizabeth Smith , Liwu Hong , Tanweer Khan , Shihong Ying , Hongwu Wang , Peter D. Williams , Jae-Hun Kim , M. Brad Nolt , Maryann Caplen
IPC: A61K31/519 , A61K45/06 , C07D487/04 , A61K31/4985 , C07D519/00 , C07D413/14 , A61K31/496 , C07D498/04 , C07D403/14 , C07D413/10 , C07D498/14 , A61K31/5383 , A61K31/4178 , A61K31/4188 , A61K31/424 , A61K31/4355 , A61K31/429 , C07D513/04 , A61P31/18
Abstract: The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
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公开(公告)号：US10138212B2
公开(公告)日：2018-11-27
申请号：US15549242
申请日：2016-02-01
Applicant: Merck Sharp & Dohme Corp.
Inventor： Amjad Ali , Rongze Kuang , Yeon-Hee Lim , Michael Man-Chu Lo , Pauline C. Ting , Purakkattle Biju , Manuel de Lera Ruiz , Sylvia J. Degrado , Alexander L. Tung , Timothy J. Henderson , Liwu Hong , Jae-Hun Kim , Dong Won-Shik Kim , Joe Lee , Jie Wu , Heping Wu , Yushi Xiao , Tao Yu , Gang Zhou , Xiaohong Zhu , Kevin D. McCormick , Jayaram R. Tagat , Dong Xiao , Tanweer Khan , Jianhua Cao , Michael Berlin , Yonglian Zhang
IPC: C07D239/84 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61P25/14 , A61K31/517
Abstract: The present invention is directed to compounds of generic formula I: or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist.
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公开(公告)号：US20180037554A1
公开(公告)日：2018-02-08
申请号：US15549242
申请日：2016-02-01
Applicant: Merck Sharp & Dohme Corp.
Inventor： Amjad Ali , Rongze Kuang , Yeon-Hee Lim , Michael Man-Chu Lo , Pauline C. Ting , Purakkattle Biju , Manuel de Lera Ruiz , Sylvia J. Degrado , Alexander L. Tung , Timothy J. Henderson , Liwu Hong , Jae-Hun Kim , Dong Won-Shik Kim , Joe Lee , Jie Wu , Heping Wu , Yushi Xiao , Tao Yu , Gang Zhou , Xiaohong Zhu , Kevin D. McCormick , Jayaram R. Tagat , Dong Xiao , Tanweer Khan , Jianhua Cao , Michael Berlin , Yonglian Zhang
IPC: C07D239/84 , C07D401/14 , C07D413/12 , C07D417/12 , C07D405/12 , C07D417/14 , C07D413/14 , C07D471/04 , C07D401/12 , C07D403/12
CPC classification number: C07D239/84 , A61K31/517 , A61P25/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: The present invention is directed to compounds of generic formula I: or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist.
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