公开(公告)号：US20200261421A1

公开(公告)日：2020-08-20

申请号：US16461952

申请日：2017-12-19

Applicant: Merck Sharp & Dohme Corp.

Inventor： Brian McKittrick ,  John P. Caldwell ,  John A. McCauley ,  Henry Vaccaro ,  Tin-Yau Chan ,  Hyunjin Kim ,  Elizabeth Smith ,  Liwu Hong ,  Tanweer Khan ,  Shihong Ying ,  Hongwu Wang

IPC: A61K31/4168 ,  A61K45/06 ,  A61K31/497 ,  C07D233/72 ,  C07D403/12 ,  C07D401/12 ,  A61P31/18

Abstract: The present invention is directed to compounds of Formula I, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

公开(公告)号：US20200069691A1

公开(公告)日：2020-03-05

申请号：US16461899

申请日：2017-12-19

Applicant: Merck Sharp & Dohme Corp.

Inventor： Brian McKittrick ,  John P. Caldwell ,  John McCauley ,  Henry Vaccaro ,  Tin-Yau Chan ,  Hyunjin Kim ,  Elizabeth Smith ,  Liwu Hong ,  Tanweer Khan ,  Shihong Ying ,  Hongwu Wang ,  Peter D. Williams ,  Jae-Hun Kim ,  M. Brad Nolt ,  Maryann Caplen

IPC: A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  A61K31/4985 ,  C07D519/00 ,  C07D413/14 ,  A61K31/496 ,  C07D498/04 ,  C07D403/14 ,  C07D413/10 ,  C07D498/14 ,  A61K31/5383 ,  A61K31/4178 ,  A61K31/4188 ,  A61K31/424 ,  A61K31/4355 ,  A61K31/429 ,  C07D513/04 ,  A61P31/18

Abstract: The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.