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公开(公告)号：US20170305923A1
公开(公告)日：2017-10-26
申请号：US14895613
申请日：2014-06-09
发明人： Mark W. Embrey , John M. Sanders , Kerim Babaoglu , Abbas Walji , John S. Wai , Paul J. Coleman
IPC分类号： C07D487/14 , A61K45/06 , A61K31/4985 , A61K31/5383 , C07D498/14 , C07D491/048
CPC分类号： C07D487/14 , A61K31/4985 , A61K31/5383 , A61K45/06 , C07D491/048 , C07D491/147 , C07D498/14
摘要： The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, m, R1, R5, Ra and Rb are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocycle Derivative, and methods of using the Fused Tricyclic Heterocycle Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US20150329539A1
公开(公告)日：2015-11-19
申请号：US14652580
申请日：2013-12-12
发明人： Mark W. Embrey , Thomas H. Graham , Abbas Walji , Sherman T. Waddell , Tao Yu , Yonglian Zhang , Wensheng Liu , Paul J. Coleman , John Wai , Thomas Steele , Christina Di Marco
IPC分类号： C07D471/04 , C07D471/10 , C07D471/20 , A61K45/06 , A61K31/675 , C07D471/14 , A61K31/55 , A61K31/4985 , A61K31/53 , C07F9/6521
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/53 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/10 , C07D471/14 , C07D471/20 , C07D491/20 , C07D495/20 , C07D498/14 , C07F9/6521
摘要： The present invention relates to 4-Pyridinonetriazine Derivatives of Formula (I); and pharmaceutically acceptable salts thereof, wherein A, X, Y, R1, R2, R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one 4-Pyridinonetriazine Derivative, and methods of using the 4-Pyridinonetriazine Derivatives for treating or preventing HIV infection in a subject.
摘要翻译： 本发明涉及式（I）的4-吡啶酮三嗪衍生物; 其中A，X，Y，R 1，R 2，R 3和R 5如本文所定义。 本发明还涉及包含至少一种4-吡啶酮三嗪衍生物的组合物，以及使用4-吡啶酮三嗪衍生物治疗或预防受试者中HIV感染的方法。
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公开(公告)号：US11413292B2
公开(公告)日：2022-08-16
申请号：US16966961
申请日：2019-02-11
IPC分类号： A61K31/53 , A61K31/427 , A61K31/4418 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/5365 , A61K31/635 , A61K31/675 , A61K31/7068 , C07D471/18 , C07D498/18
摘要： The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, Z, R1 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
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公开(公告)号：US20210284694A1
公开(公告)日：2021-09-16
申请号：US17253864
申请日：2019-06-20
发明人： Alonso Ricardo , Thomas Joseph Tucker , Nicolas Cedric Boyer , Joseph R. Stringer , Derek M. LaPlaca , Angela Dawn Kerekes , Chengwei Wu , Sookhee Nicole Ha , Hyewon Youm , Mark W. Embrey , Elisabetta Bianchi , Danila Branca , Raffaele Ingenito , Willy Costantini , Alessia Santoprete , Roberto Costante , Immacolata Conte , Stefania Colarusso , Eric J. Gilbert , Aurash Shahripour , Yusheng Xiong
IPC分类号： C07K7/64
摘要： Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit interaction between human PCSK9 and human low density lipoprotein receptor (LDLR), and pharmaceutical compositions comprising one or more of these compounds. Also provided are methods of reducing LDL cholesterol level in a subject in need thereof that include administering to the subject one or more of the cyclic polypeptide compounds or a pharmaceutical composition provided herein.
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公开(公告)号：US10221186B2
公开(公告)日：2019-03-05
申请号：US15533169
申请日：2015-12-04
发明人： Mark W. Embrey , Thomas H. Graham , Izzat T. Raheem , John D. Schreier , Sherman T. Waddell , John S. Wai , Lihong Hu , Xuanjia Peng
IPC分类号： A61K31/499 , A61K31/675 , A61K31/683 , C07F9/6561 , C07D487/20 , C07D491/20 , A61K45/06 , A61P31/18
摘要： The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R4 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
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公开(公告)号：US20170362252A1
公开(公告)日：2017-12-21
申请号：US15533068
申请日：2015-12-04
IPC分类号： C07D498/14 , A61K31/553 , A61K31/4985 , A61K31/5365 , C07D491/20 , C07D471/04
CPC分类号： C07D498/14 , A61K31/427 , A61K31/4402 , A61K31/47 , A61K31/4985 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/5365 , A61K31/55 , A61K31/553 , A61K31/635 , A61K31/675 , A61K31/7072 , A61K45/06 , C07D471/04 , C07D491/20 , A61K2300/00
摘要： The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
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公开(公告)号：US09714243B2
公开(公告)日：2017-07-25
申请号：US14652580
申请日：2013-12-12
发明人： Mark W. Embrey , Thomas H. Graham , Abbas Walji , Sherman T. Waddell , Tao Yu , Yonglian Zhang , Wensheng Liu , Paul J. Coleman , John Wai , Thomas Steele , Christina Di Marco
IPC分类号： C07D471/04 , A61K31/53 , C07D471/10 , C07F9/6521 , A61K31/675 , A61K31/55 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D471/20 , C07D491/20 , C07D495/20 , C07D498/14
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/53 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/10 , C07D471/14 , C07D471/20 , C07D491/20 , C07D495/20 , C07D498/14 , C07F9/6521
摘要： The present invention relates to 4-Pyridinonetriazine Derivatives of Formula (I); and pharmaceutically acceptable salts thereof, wherein A, X, Y, R1, R2, R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one 4-Pyridinonetriazine Derivative, and methods of using the 4-Pyridinonetriazine Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US20210361662A1
公开(公告)日：2021-11-25
申请号：US16966961
申请日：2019-02-11
IPC分类号： A61K31/53 , C07D471/18 , C07D498/18 , A61K31/513 , A61K31/7068 , A61K31/427 , A61K31/635 , A61K31/4418 , A61K31/675 , A61K31/505 , A61K31/52 , A61K31/5365
摘要： The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, Z, R1 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
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公开(公告)号：US10150780B2
公开(公告)日：2018-12-11
申请号：US15533068
申请日：2015-12-04
IPC分类号： A61K31/4985 , C07D498/14 , A61K45/06 , A61K31/427 , A61K31/4402 , A61K31/47 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/5365 , A61K31/55 , A61K31/635 , A61K31/675 , A61K31/7072 , C07D471/04 , C07D491/20 , A61K31/553
摘要： The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
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公开(公告)号：US09951079B2
公开(公告)日：2018-04-24
申请号：US14895613
申请日：2014-06-09
发明人： Mark W. Embrey , Kerim Babaoglu , Abbas Walji , John S. Wai , Paul J. Coleman
IPC分类号： C07D487/14 , C07D498/14 , C07D491/048 , A61K31/5383 , A61K31/4965 , A61K45/06 , A61K31/4985
CPC分类号： C07D487/14 , A61K31/4985 , A61K31/5383 , A61K45/06 , C07D491/048 , C07D491/147 , C07D498/14
摘要： The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, m, R1, R5, Ra and Rb are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocycle Derivative, and methods of using the Fused Tricyclic Heterocycle Derivatives for treating or preventing HIV infection in a subject.
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