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公开(公告)号：US20140323482A1
公开(公告)日：2014-10-30
申请号：US14366466
申请日：2012-12-17
发明人： Yao Ma , Manami Shizuka , Timothy J. Guzi , Yuan Liu , Yuan Tian , Brian R. Lahue , Craig R. Gibeau , Gerald W. Shipps, JR. , Yaolin Wang , Stephane L. Bogen , Latha G. Nair , Weidong Pan , Mark A. McCoy , Matthew E. Voss , Margarita Kirova-Snover , W. Bent Clayton
IPC分类号： C07D495/04 , C07D409/14
CPC分类号： C07D495/04 , C07D409/14
摘要： The present invention provides a compound of Formula I (The formula should be inserted here) as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的式I化合物（该式应该在此插入）或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：US09062071B2
公开(公告)日：2015-06-23
申请号：US14366466
申请日：2012-12-17
发明人： Yao Ma , Manami Shizuka , Timothy J. Guzi , Yuan Liu , Yuan Tian , Brian R. Lahue , Craig R. Gibeau , Gerald W. Shipps, Jr. , Yaolin Wang , Stephane L. Bogen , Latha G. Nair , Weidong Pan , Mark A. McCoy , Matthew E. Voss , Margarita Kirova-Snover , W. Bent Clayton
IPC分类号： C07D409/14 , C07D495/04 , A61K31/497
CPC分类号： C07D495/04 , C07D409/14
摘要： The present invention provides a compound of Formula I (The formula should be inserted here) as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的式I化合物（该式应该在此插入）或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：US08962611B2
公开(公告)日：2015-02-24
申请号：US14465577
申请日：2014-08-21
发明人： Matthew P. Christopher , Francesc Xavier Fradera Llinas , Michelle Machacek , Michelle Martinez , Michael Hale Reutershan , Manami Shizuka , Binyuan Sun , Christopher Francis Thompson , B. Wesley Trotter , Matthew E. Voss , Michael D. Altman , Stephane L. Bogen , Ronald J. Doll
IPC分类号： A61K31/553 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/08 , C07D498/04 , C07D519/00
摘要： The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的取代的咪唑并吡啶或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：US08846657B2
公开(公告)日：2014-09-30
申请号：US14132946
申请日：2013-12-18
发明人： Matthew P. Christopher , Francesc Xavier Fradera Llinas , Michelle Machacek , Michelle Martinez , Michael Hale Reutershan , Manami Shizuka , Binyuan Sun , Christopher Francis Thompson , B. Wesley Trotter , Matthew E. Voss , Michael D. Altman , Stephane L. Bogen , Ronald J. Doll
IPC分类号： A61K31/553 , C07D471/04 , C07D471/08 , C07D498/04
CPC分类号： C07D471/04 , C07D471/08 , C07D498/04 , C07D519/00
摘要： The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的取代的咪唑并吡啶或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：US20150368247A1
公开(公告)日：2015-12-24
申请号：US14764616
申请日：2014-02-04
申请人： Matthew P. CHRISTOPHER , Francesc Xavier FRADERA LLINAS , Michelle MACHACEK , Michelle MARTINEZ , Michael Hale REUTERSHAN , Manami SHIZUKA , Binyuan SUN , Christopher Francis THOMPSON , Wesley B. TROTTER , Matthew E. VOSS , Liping YANG , Merck Sharp & Dohme Corp.
发明人： Matthew P. Christopher , Francesc Xavier Fradera Llinas , Michelle Machacek , Michelle Martinez , Michael Hale Reutershan , Manami Shizuka , Binyuan Sun , Christopher Francis Thompson , B. Wesley Trotter , Matthew E. Voss , Liping Yang
IPC分类号： C07D473/34 , C07D473/00 , C07D473/30
CPC分类号： C07D473/34 , C07D473/00 , C07D473/30
摘要： The present invention provides 2,6,7 substituted purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供2,6,7本文所述的取代嘌呤或其药学上可接受的盐。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：US20150353553A1
公开(公告)日：2015-12-10
申请号：US14762827
申请日：2014-01-29
发明人： Carolyn Michele Cammarano , Matthew P. Christopher , Christopher Dinsmore , Ronald J. Doll , Francesc Xavier Fradera Llinas , Chaomin Li , Michelle Machacek , Michelle Martinez , Latha G. Nair , Weidong Pan , Michael Hale Reutershan , Manami Shizuka , Dietrich P. Steinhuebel , Binyuan Sun , Christopher Francis Thompson , B. Wesley Trotter , Yaolin Wang , Liping Yang , Stephane L. Bogen , Matthew E. Voss , Jagannath Panda , Anthappan Tony Kurissery
IPC分类号： C07D473/34 , C07D473/16
CPC分类号： C07D473/00 , C07D473/16 , C07D473/30 , C07D473/34
摘要： The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的2,6,7,8取代的嘌呤或其药学上可接受的盐。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：US20140357618A1
公开(公告)日：2014-12-04
申请号：US14465577
申请日：2014-08-21
发明人： Matthew P. Christopher , Francesc Xavier Fradera Llinas , Michelle Machacek , Michelle Martinez , Michael Hale Reutershan , Manami Shizuka , Binyuan Sun , Christopher Francis Thompson , B. Wesley Trotter , Matthew E. Voss , Michael D. Altman , Stephane L. Bogen , Ronald J. Doll
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/08 , C07D498/04 , C07D519/00
摘要： The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的取代的咪唑并吡啶或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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8.发明申请公开(公告)号：US20140336222A1
公开(公告)日：2014-11-13
申请号：US14339925
申请日：2014-07-24
发明人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew E. Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
IPC分类号： C07D401/14 , C07D409/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译： 本发明提供本文所述的式1的化合物或其药学上可接受的盐，溶剂合物或酯。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。
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公开(公告)号：US09682978B2
公开(公告)日：2017-06-20
申请号：US14764616
申请日：2014-02-04
发明人： Matthew P. Christopher , Francesc Xavier Fradera Llinas , Michelle Machacek , Michelle Martinez , Michael Hale Reutershan , Manami Shizuka , Binyuan Sun , Christopher Francis Thompson , B. Wesley Trotter , Matthew E. Voss , Liping Yang
IPC分类号： C07D473/30 , C07D473/34 , C07D473/00
CPC分类号： C07D473/34 , C07D473/00 , C07D473/30
摘要： The present invention provides 2,6,7 substituted purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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公开(公告)号：US09637493B2
公开(公告)日：2017-05-02
申请号：US14652466
申请日：2013-12-18
发明人： Christopher Dinsmore , Francesc Xavier Fradera Llinas , Amit Ashokro Kudale , Michelle Machacek , Michael Hale Reutershan , Christopher Francis Thompson , B. Wesley Trotter , Liping Yang , Michael D. Altman , Stephane L. Bogen , Ronald J. Doll , Matthew E. Voss
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides substituted pyrrolopyrimidines of Formula I as described herein or a pharmaceutically acceptable salt or solvate thereof: The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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