-
公开(公告)号：US08993756B2
公开(公告)日：2015-03-31
申请号：US14363097
申请日：2012-11-30
发明人： Sean P. Ahearn , Matthew Christopher , Christopher Dinsmore , Joon Jung , Qinglin Pu , Alexey Rivkin , Mark E. Scott , David J. Witter , Hyun Chong Woo , Brandon Cash
IPC分类号： C07D487/04 , C07D417/04 , C07D413/04 , A61K31/519 , A61P19/02 , C07D519/00 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of formula I which are JAK3 inhibitors. Specifically, the compounds of formula I are pyrrolo[2,3-d]pyrimidine derivative compounds. The instant invention also provides methods of treating JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer, by administering the pyrrolo[2,3-d]pyrimidine-derivative compounds of formula I.
摘要翻译： 本发明提供了作为JAK3抑制剂的式I化合物。 具体地，式I化合物是吡咯并[2,3-d]嘧啶衍生物化合物。 本发明还提供了通过给予式I的吡咯并[2,3-d]嘧啶衍生物化合物来治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症的方法。
-
公开(公告)号：US20140349998A1
公开(公告)日：2014-11-27
申请号：US14363097
申请日：2012-11-30
发明人： Sean P Ahearn , Matthew Christopher , Christopher Dinsmore , Joon Jung , Qinglin Pu , Alexey Rivkin , Mark E. Scott , David J. Witter , Hyun Chong Woo , Brandon Cash
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of formula I which are JAK3 inhibitors. Specifically, the compounds of formula I are pyrrolo[2,3-d]pyrimidine derivative compounds. The instant invention also provides methods of treating JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer, by administering the pyrrolo[2,3-d]pyrimidine-derivative compounds of formula I.
摘要翻译： 本发明提供了作为JAK3抑制剂的式I化合物。 具体地，式I化合物是吡咯并[2,3-d]嘧啶衍生物化合物。 本发明还提供了通过给予式I的吡咯并[2,3-d]嘧啶衍生物化合物来治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症的方法。
-
公开(公告)号：US09637493B2
公开(公告)日：2017-05-02
申请号：US14652466
申请日：2013-12-18
发明人： Christopher Dinsmore , Francesc Xavier Fradera Llinas , Amit Ashokro Kudale , Michelle Machacek , Michael Hale Reutershan , Christopher Francis Thompson , B. Wesley Trotter , Liping Yang , Michael D. Altman , Stephane L. Bogen , Ronald J. Doll , Matthew E. Voss
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides substituted pyrrolopyrimidines of Formula I as described herein or a pharmaceutically acceptable salt or solvate thereof: The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
-
公开(公告)号：US09540377B2
公开(公告)日：2017-01-10
申请号：US14762827
申请日：2014-01-29
发明人： Carolyn Michele Cammarano , Matthew P. Christopher , Christopher Dinsmore , Ronald J. Doll , Francesc Xavier Fradera Llinas , Chaomin Li , Michelle Machacek , Michelle Martinez , Latha G. Nair , Weidong Pan , Michael Hale Reutershan , Manami Shizuka , Dietrich P. Steinhuebel , Binyuan Sun , Christopher Francis Thompson , B. Wesley Trotter , Yaolin Wang , Liping Yang , Stephane L. Bogen , Matthew E. Voss , Jagannath Panda , Anthappan Tony Kurissery
IPC分类号： A61K31/52 , C07D473/16 , C07D473/00 , C07D473/34 , C07D473/30
CPC分类号： C07D473/00 , C07D473/16 , C07D473/30 , C07D473/34
摘要： The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的2,6,7,8取代的嘌呤或其药学上可接受的盐。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
-
5.发明申请N-(2-CYANO HETEROCYCLYL) PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 有权N-（2-氰基杂环基）吡唑并吡喃酮作为甘薯激酶抑制剂公开(公告)号：US20160272633A1
公开(公告)日：2016-09-22
申请号：US14778052
申请日：2014-03-19
申请人： Christopher DINSMORE , Peter FULLER , David GUERIN , Christopher F. THOMPSON , Qinglin PU , Mark E. SCOTT , Jason David KATZ , Ravi KURUKLASURIYA , Joshua T. CLOSE , Danielle FALCONE , Jason BRUDAKER , Hongbo ZENG , Yunfeng BAI , Jianmin FU , Norman KONG , Yumei LIU , Zhixiang ZHENG , MERCK SHARP & DOHME CORP.
发明人： Christopher Dinsmore , Peter Fuller , David Guerin , Christopher F. Thompson , Qinglin Pu , Mark E. Scott , Jason David Katz , Ravi Kuruklasuriya , Joshua T. Close , Danielle Falcone , Jason Brubaker , Hongbo Zeng , Yunfeng Bai , Jianmin Fu , Norman Kong , Yumei Liu , Zhixiang Zheng
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.
-
公开(公告)号：US09096598B2
公开(公告)日：2015-08-04
申请号：US14349377
申请日：2012-09-28
发明人： John W. Butcher , David Witter , Christopher Dinsmore , June Kim , John Hendrix , Raksha Archarya , Sean P. Ahearn , Joon Jung , Alexey Rivkin , Philip Jones
IPC分类号： C07D401/10 , A61K31/437 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译： 本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。
-
公开(公告)号：US10072025B2
公开(公告)日：2018-09-11
申请号：US15519740
申请日：2015-10-21
发明人： Mark E. Scott , David Guerin , Danielle Molinari , Sam Kattar , Peter Fuller , Christopher Dinsmore , Norman Kong , Yunfeng Bai , Jianmin Fu , Yumei Liu , Zhixiang Zheng
IPC分类号： C07D519/00 , C07D471/04 , A61K31/4545 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/554 , A61K31/541
CPC分类号： C07D519/00 , A61K31/00 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/55 , A61K31/553 , A61K31/554 , A61P11/06 , A61P19/02 , A61P35/00 , C07D471/04
摘要： The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.
-
公开(公告)号：US09957265B2
公开(公告)日：2018-05-01
申请号：US14778052
申请日：2014-03-19
发明人： Christopher Dinsmore , Peter Fuller , David Guerin , Christopher F. Thompson , Qinglin Pu , Mark E. Scott , Jason David Katz , Ravi Kurukulasuriya , Joshua T. Close , Danielle Falcone , Jason Brubaker , Hongbo Zeng , Yunfeng Bai , Jianmin Fu , Norman Kong , Yumei Liu , Zhixiang Zheng
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.
-
公开(公告)号：US10059705B2
公开(公告)日：2018-08-28
申请号：US14778055
申请日：2014-03-19
发明人： Christopher Dinsmore , Peter Fuller , David Guerin , Jason David Katz , Christopher F. Thompson , Danielle Falcone , Wei Deng , Luis Torres , Hongbo Zeng , Yunfeng Bai , Jianmin Fu , Norman Kong , Yumei Liu , Zhixiang Zheng , Mark E. Scott
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
-
公开(公告)号：US20160272634A1
公开(公告)日：2016-09-22
申请号：US14778055
申请日：2014-03-19
申请人： Christopher DINSMORE , Peter FULLER , David GUERIN , Jason David KATZ , Christopher F. THOMPSON , Danielle FALCONE , Wei DENG , Luis TORRES , Hongbo ZENG , Yunfeng BAI , Jianmin FU , Norman KONG , Yumei LIU , Zhixiang ZHENG , Mark E. SCOTT , MERCK SHARP & DOHME CORP.
发明人： Christopher Dinsmore , Peter Fuller , David Guerin , Jason David Katz , Christopher F. Thompson , Danielle Falcone , Wei Deng , Luis Torres , Hongbo Zeng , Yunfeng Bai , Jianmin Fu , Norman Kong , Yumei Liu , Zhixiang Zheng , Mark E. Scott
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译： 本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.043 秒)
