公开(公告)号：US09226922B2

公开(公告)日：2016-01-05

申请号：US14431485

申请日：2013-09-26

Applicant: Merck Sharp & Dohme Corp.

Inventor： Kevin J. Wilson ,  David J. Witter ,  Matthew H. Daniels ,  Angie R. Angeles ,  Phieng Siliphaivanh ,  David Sloman ,  Brendan O'Boyle ,  Danielle Falcone ,  Catherine White ,  Ron Ferguson ,  Wei Zhou ,  Kathryn Lipford ,  Umar Faruk Mansoor ,  Salem Fevrier ,  Xianhai Huang ,  Ravi Kurukulasuriya ,  Judson E. Richard ,  Shuyi Tang ,  Christopher Boyce ,  Joseph Kozlowski ,  Raman Kumar Bakshi ,  Ganesh Babu Karunakaran

IPC: C07D401/14 ,  A61K31/437 ,  C07D471/04 ,  A61K45/06 ,  A61K31/4545

CPC classification number: A61K31/437 ,  A61K31/4545 ,  A61K45/06 ,  C07D471/04

Abstract: Disclosed are the ERK inhibitors of formula (1.0), having a pyrazolopyridine base structure, and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1.0).

Abstract translation: 公开了具有吡唑并吡啶基结构的式（1.0）的ERK抑制剂及其药学上可接受的盐。 还公开了使用式（1.0）化合物治疗癌症的方法。

公开(公告)号：US20150258074A1

公开(公告)日：2015-09-17

申请号：US14431485

申请日：2013-09-26

Applicant: Kevin J. WILSON ,  David J. WITTER ,  Matthew H. DANIELS ,  Angie R. ANGELES ,  Phieng SILIPHAIVANH ,  David L. SLOMAN ,  Brendan O'BOYLE ,  Danielle FALCONE ,  Catherine WHITE ,  Ron FERGUSON ,  Wei ZHOU ,  Kathryn LIPFORD ,  Umar Faruk MANSOOR ,  Salem FEVRIRE ,  Xianhai HUANG ,  Ravi KURUKULASURIYA ,  Judson E. RICHARD ,  Shuyi TANG ,  Christopher BOYCE ,  Joseph KOZLOWSKI ,  Raman Kumar BAKSHI ,  Ganesh Babu UNAKARAN ,  Merck Sharp & Dohme Corp.

Inventor： Kevin J. Wilson ,  David J. Witter ,  Matthew H. Daniels ,  Angie R. Angeles ,  Phieng Siliphaivanh ,  David Sloman ,  Brendan O'Boyle ,  Danielle Falcone ,  Catherine White ,  Ron Ferguson ,  Wei Zhou ,  Kathryn Lipford ,  Umar Faruk Mansoor ,  Salem Fevrier ,  Xianhai Huang ,  Ravi Kurukulasuriya ,  Judson E. Richard ,  Shuyi Tang ,  Christopher Boyce ,  Joseph Kozlowski ,  Raman Kumar Bakshi ,  Ganesh Babu Karunakaran

IPC: A61K31/437 ,  A61K45/06 ,  A61K31/4545 ,  C07D471/04

CPC classification number: A61K31/437 ,  A61K31/4545 ,  A61K45/06 ,  C07D471/04

Abstract: Disclosed are the ERK inhibitors of formula (1.0), having a pyrazolopyridine base structure, and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1.0).

Abstract translation: 公开了具有吡唑并吡啶基结构的式（1.0）的ERK抑制剂及其药学上可接受的盐。 还公开了使用式（1.0）化合物治疗癌症的方法。