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公开(公告)号:US20170027916A1
公开(公告)日:2017-02-02
申请号:US15303322
申请日:2015-04-10
发明人: Isao Sakurada , Tomokazu Hirabayashi , Yoshitaka Maeda , Hiroshi Nagasue , Takashi Mizuno , Jiayi Xu , Ting Zhang , Cameron Smith , Dann Parker
IPC分类号: A61K31/439 , A61K45/06 , A61K31/444 , A61K31/506 , A61K31/501 , C07D519/00 , C07D413/14 , C07D498/04
CPC分类号: A61K31/439 , A61K31/444 , A61K31/501 , A61K31/506 , A61K45/06 , C07D209/52 , C07D261/20 , C07D413/04 , C07D413/14 , C07D498/04 , C07D519/00
摘要: In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译: 在其许多实施方案中,本发明提供了由式(I)表示的新一类苯甲酰胺化合物或其药学上可接受的盐或溶剂化物,或包含一种或多种所述化合物或其药学上可接受的盐或溶剂化物的药物组合物,以及使用 所述化合物或其药学上可接受的盐或溶剂合物用于治疗或预防血栓形成,栓塞,高凝状态或纤维变性。
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公开(公告)号:US20180030036A1
公开(公告)日:2018-02-01
申请号:US15534029
申请日:2015-12-07
申请人: Ting ZHANG , Yi-Heng CHEN , Liangqin GUO , Alan HARUZA , Tianying JIAN , Bing LI , Dongfang MENG , Dann L. PARKER, JR. , Edward C. SHERER , Harold B. WOOD , Isao SAKURADA , MERCK SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD
发明人: Ting Zhang , Yi-Heng Chen , Liangqin Guo , Alan Hruza , Tianying Jian , Bing Li , Dongfang Meng , Dann L. Parker , Edward C. Sherer , Harold B. Wood , Isao Sakurada
IPC分类号: C07D403/12 , C07D401/14 , C07D401/12 , C07D471/04
CPC分类号: C07D403/12 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要: The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号:US10189819B2
公开(公告)日:2019-01-29
申请号:US15534029
申请日:2015-12-07
发明人: Ting Zhang , Yi-Heng Chen , Liangqin Guo , Alan Hruza , Tianying Jian , Bing Li , Dongfang Meng , Dann L. Parker , Edward C. Sherer , Harold B. Wood , Isao Sakurada
IPC分类号: C07D403/12 , C07D401/14 , C07D401/12 , C07D471/04 , C07D413/14 , C07D413/12 , C07D417/12
摘要: The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号:US09808445B2
公开(公告)日:2017-11-07
申请号:US15303322
申请日:2015-04-10
发明人: Isao Sakurada , Tomokazu Hirabayashi , Yoshitaka Maeda , Hiroshi Nagasue , Takashi Mizuno , Jiayi Xu , Ting Zhang , Cameron Smith , Dann Parker
IPC分类号: A61K31/501 , A61K31/439 , C07D413/14 , C07D261/20 , C07D413/04 , C07D498/04 , C07D209/52 , C07D519/00 , A61K31/444 , A61K31/506 , A61K45/06
CPC分类号: A61K31/439 , A61K31/444 , A61K31/501 , A61K31/506 , A61K45/06 , C07D209/52 , C07D261/20 , C07D413/04 , C07D413/14 , C07D498/04 , C07D519/00
摘要: In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
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