公开(公告)号：US11524076B2

公开(公告)日：2022-12-13

申请号：US16645068

申请日：2018-09-04

申请人： Merck Sharp & Dohme Corp. ,  Richard J. Porambo ,  Chitrananda Abeygunawardana ,  Luwy Kavuka Musey ,  Michael J. Kosinski ,  Yadong Adam Cui ,  Patrick McHugh ,  Janelle Konietzko

发明人： Richard J. Porambo ,  Chitrananda Abeygunawardana ,  Luwy Kavuka Musey ,  Michael J. Kosinski ,  Yadong Adam Cui ,  Patrick McHugh ,  Janelle Konietzko

IPC分类号： A61K47/26 ,  A61K47/54 ,  A61K47/36 ,  A61K47/42

摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.

公开(公告)号：US11491216B2

公开(公告)日：2022-11-08

申请号：US16645048

申请日：2018-09-04

申请人： Merck Sharp & Dohme Corp. ,  Richard J. Porambo ,  Chitrananda Abeygunawardana ,  Luwy Kavuka Musey ,  Michael J. Kosinski ,  Yadong Adam Cui ,  Julie Marie Skinner

发明人： Richard J. Porambo ,  Chitrananda Abeygunawardana ,  Luwy Kavuka Musey ,  Michael J. Kosinski ,  Yadong Adam Cui ,  Julie Marie Skinner

IPC分类号： A61K39/09 ,  A61K39/39 ,  A61K47/42

摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.

公开(公告)号：US20200330578A1

公开(公告)日：2020-10-22

申请号：US16645048

申请日：2018-09-04

申请人： Richard J. PORAMBO ,  Chitrananda ABEYGUNAWARDANA ,  Luwy Kavuka MUSEY ,  Michael J. KOSINSKI ,  Yadong Adam CUI ,  Julie Marie SKINNER ,  Merck Sharp & Dohme Corp.

发明人： Richard J. Porambo ,  Chitrananda Abeygunawardana ,  Luwy Kavuka Musey ,  Michael J. Kosinski ,  Yadong Adam Cui ,  Julie Marie Skinner

IPC分类号： A61K39/09 ,  A61K47/42 ,  A61K39/39

摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.

公开(公告)号：US20200282070A1

公开(公告)日：2020-09-10

申请号：US16645080

申请日：2018-09-04

申请人： Richard J. PORAMBO ,  Chitrananda ABEYGUNAWARDANA ,  Luwy Kavuka MUSEY ,  Michael J. KOSINSKI ,  Yadong Adam CUI ,  Merck Sharp & Dohme Corp.

发明人： Richard J. Porambo ,  Chitrananda Abeygunawardana ,  Luwy Kavuka Musey ,  Michael J. Kosinski ,  Yadong Adam Cui

IPC分类号： A61K47/61 ,  C08B37/00 ,  A61K47/64 ,  A61K39/09 ,  A61K39/39 ,  A61K47/02 ,  A61K47/22 ,  A61P37/04

摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.

公开(公告)号：US20200282040A1

公开(公告)日：2020-09-10

申请号：US16645023

申请日：2018-09-04

申请人： Merck Sharp & Dohme Corp.

发明人： Richard J. Porambo ,  Chitrananda Abeygunawardana ,  Luwy Kavuka Musey ,  Michael J. Kosinski ,  Yadong Adam Cui

IPC分类号： A61K39/09 ,  C08B37/00 ,  A61K39/39 ,  A61K47/54 ,  A61K47/64 ,  A61K47/02 ,  A61K47/22 ,  A61P37/04

摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these N serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.

公开(公告)号：US20210038723A1

公开(公告)日：2021-02-11

申请号：US16645068

申请日：2018-09-04

申请人： Merck Sharp & Dohme Corp.

发明人： Richard J. Porambo ,  Chitrananda Abeygunawardana ,  Luwy Kavuka Musey ,  Michael J. Kosinski ,  Yadong Adam Cui ,  Patrick McHugh ,  Janelle Konietzko

IPC分类号： A61K47/26 ,  A61K47/42 ,  A61K47/36 ,  A61K47/54

摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.