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1.发明授权公开(公告)号：US11524076B2
公开(公告)日：2022-12-13
申请号：US16645068
申请日：2018-09-04
申请人： Merck Sharp & Dohme Corp. , Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui , Patrick McHugh , Janelle Konietzko
发明人： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui , Patrick McHugh , Janelle Konietzko
摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.
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2.发明授权公开(公告)号：US11491216B2
公开(公告)日：2022-11-08
申请号：US16645048
申请日：2018-09-04
申请人： Merck Sharp & Dohme Corp. , Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui , Julie Marie Skinner
发明人： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui , Julie Marie Skinner
摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
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3.发明申请公开(公告)号：US20200330578A1
公开(公告)日：2020-10-22
申请号：US16645048
申请日：2018-09-04
申请人： Richard J. PORAMBO , Chitrananda ABEYGUNAWARDANA , Luwy Kavuka MUSEY , Michael J. KOSINSKI , Yadong Adam CUI , Julie Marie SKINNER , Merck Sharp & Dohme Corp.
发明人： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui , Julie Marie Skinner
摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
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4.发明申请公开(公告)号：US20200282070A1
公开(公告)日：2020-09-10
申请号：US16645080
申请日：2018-09-04
申请人： Richard J. PORAMBO , Chitrananda ABEYGUNAWARDANA , Luwy Kavuka MUSEY , Michael J. KOSINSKI , Yadong Adam CUI , Merck Sharp & Dohme Corp.
发明人： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui
IPC分类号： A61K47/61 , C08B37/00 , A61K47/64 , A61K39/09 , A61K39/39 , A61K47/02 , A61K47/22 , A61P37/04
摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
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公开(公告)号：US20210177957A1
公开(公告)日：2021-06-17
申请号：US16769874
申请日：2018-12-04
申请人： William J. SMITH , Patrick MCHUGH , Michael Albert WINTERS , Julie M. SKINNER , Jian HE , Luwy MUSEY , Chitrananda ABEYGUNAWARDANA , Yadong Adam CUI , Michael J. KOSINSKI , Merck Sharp & Dohme Corp.
发明人： William J. Smith , Patrick McHugh , Michael Albert Winters , Julie M. Skinner , Jian He , Luwy Musey , Chitrananda Abeygunawardana , Yadong Adam Cui , Michael J. Kosinski
摘要： The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimens that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
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公开(公告)号：US20220296695A1
公开(公告)日：2022-09-22
申请号：US17312442
申请日：2019-12-17
申请人： Chitrananda ABEYGUNAWARDANA , Yadong Adam CUI , Romulo FERRERO , Jian HE , Luwy MUSEY , Tanaz PETIGARA , Julie M. SKINNER , Merck Sharp & Dohme Corp.
发明人： Chitrananda Abeygunawardana , Yadong Adam Cui , Romulo Ferrero , Jian He , Luwy Musey , Tanaz Petigara , Julie M. Skinner
摘要： The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and/or pneumococcal diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
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公开(公告)号：US07157443B2
公开(公告)日：2007-01-02
申请号：US10498070
申请日：2002-12-06
申请人： Joseph G. Joyce , James C. Cook, III , Chitrananda Abeygunawardana , Karen M. Grimm , Craig T. Przysiecki , Robert W. Hepler , Charlotte C. Ip , Keith Roper , Qiuwei Xu , Kathrin U. Jansen , Paul M. Keller , Leslie D. Cope
发明人： Joseph G. Joyce , James C. Cook, III , Chitrananda Abeygunawardana , Karen M. Grimm , Craig T. Przysiecki , Robert W. Hepler , Charlotte C. Ip , Keith Roper , Qiuwei Xu , Kathrin U. Jansen , Paul M. Keller , Leslie D. Cope
IPC分类号： A61K31/715 , A61K39/02 , C07H1/00
CPC分类号： A61K39/085
摘要： A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly-1,6,β-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating this antigen from Staphylococcus aureus. The SAE can be used in a vaccine, either alone, conjugated to an immunogenic protein, and/or with an immunogenic adjuvant.
摘要翻译： 描述了具有可被N-乙酰基和O-琥珀酰基取代基取代的聚-1,6，β-2-酰胺基吡喃糖苷的一般结构的高分子量多糖细胞内粘附素（SAE）抗原。 此外，给出了用于从金黄色葡萄球菌分离该抗原的方法。 SAE可以单独用于疫苗，与免疫原性蛋白质结合，和/或用免疫原性佐剂使用。
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公开(公告)号：US11090374B2
公开(公告)日：2021-08-17
申请号：US16487550
申请日：2018-02-20
发明人： Jian He , John E. MacNair , William J. Smith , Michael A. Winters , Joseph G. Joyce , Chitrananda Abeygunawardana , Luwy Musey , Hari Pujar , Julie M. Skinner , Emily Wen , Patrick McHugh , John Michael Williams , Catherine Lancaster
IPC分类号： A61K39/09 , A61K47/64 , A61P31/04 , A61K39/116 , A61K39/00
摘要： The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
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公开(公告)号：US11116828B2
公开(公告)日：2021-09-14
申请号：US16208778
申请日：2018-12-04
发明人： William J. Smith , Patrick McHugh , Michael Albert Winters , Julie M. Skinner , Jian He , Luwy Musey , Chitrananda Abeygunawardana , Yadong Adam Cui , Michael J. Kosinski
IPC分类号： A61K39/385 , A61K39/09 , A61K39/145 , A61P31/04 , A61K9/00 , A61K39/00
摘要： The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
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10.发明申请公开(公告)号：US20200282040A1
公开(公告)日：2020-09-10
申请号：US16645023
申请日：2018-09-04
发明人： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui
IPC分类号： A61K39/09 , C08B37/00 , A61K39/39 , A61K47/54 , A61K47/64 , A61K47/02 , A61K47/22 , A61P37/04
摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these N serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.
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