公开(公告)号：US11981701B2

公开(公告)日：2024-05-14

申请号：US17266507

申请日：2019-08-05

申请人： Merck Sharp & Dohme LLC

发明人： Jongwon Lim ,  Michelle Machacek ,  Michael H. Reutershan ,  Sebastian Schneider

IPC分类号： C07H19/167 ,  A61P35/00 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07H19/04

CPC分类号： C07H19/167 ,  A61P35/00 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07H19/04

摘要： The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

公开(公告)号：US20230399341A1

公开(公告)日：2023-12-14

申请号：US18250419

申请日：2021-11-04

申请人： MERCK SHARP & DOHME LLC

发明人： David A. Candito ,  Joanna L. Chen ,  Anthony Donofrio ,  Xavier Fradera ,  Peter H. Fuller ,  Shuhei Kawamura ,  Bing Li ,  Jongwon Lim ,  Ping Liu ,  Joey L. Methot ,  Anilkumar G. Nair ,  Alexander Pasternak ,  Brandon A. Vara ,  Elsie C. Yu

IPC分类号： C07D498/04 ,  C07D401/12 ,  C07D519/00 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D471/04 ,  C07D405/14 ,  C07D495/04 ,  C07D413/04

CPC分类号： C07D498/04 ,  C07D401/12 ,  C07D519/00 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D471/04 ,  C07D405/14 ,  C07D495/04 ,  C07D413/04

摘要： Compounds of the following formula (I); or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention of an HPK1-associated disease or disorder. Also disclosed herein are compositions comprising one or more of the compounds. Further disclosed herein are uses of these compositions in the potential prevention or treatment of an HPK1-associated disease or disorder.

公开(公告)号：US20240083903A1

公开(公告)日：2024-03-14

申请号：US18264468

申请日：2022-02-15

申请人： Jongwon Lim ,  Vladimir Simov ,  Brandon A. Vara ,  Charles S. Yeung ,  Sebastian E. Schneider ,  Erin F. DiMauro ,  Merck Sharp& Dohme LLC

发明人： Jongwon Lim ,  Vladimir Simov ,  Brandon A. Vara ,  Charles S. Yeung ,  Sebastian E. Schneider ,  Erin F. DiMauro

IPC分类号： C07D487/04 ,  A61P35/00 ,  C07D209/34 ,  C07D215/20 ,  C07D217/04 ,  C07D231/56 ,  C07D235/24 ,  C07D235/26 ,  C07D237/28 ,  C07D239/84 ,  C07D263/57 ,  C07D265/36 ,  C07D277/66 ,  C07D317/56 ,  C07D471/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D487/04 ,  A61P35/00 ,  C07D209/34 ,  C07D215/20 ,  C07D217/04 ,  C07D231/56 ,  C07D235/24 ,  C07D235/26 ,  C07D237/28 ,  C07D239/84 ,  C07D263/57 ,  C07D265/36 ,  C07D277/66 ,  C07D317/56 ,  C07D471/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

摘要： The present invention is directed to a compound of Formula I: or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising them and methods of using such compounds or pharmaceutical salts thereof.