公开(公告)号：US11981701B2

公开(公告)日：2024-05-14

申请号：US17266507

申请日：2019-08-05

申请人： Merck Sharp & Dohme LLC

发明人： Jongwon Lim ,  Michelle Machacek ,  Michael H. Reutershan ,  Sebastian Schneider

IPC分类号： C07H19/167 ,  A61P35/00 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07H19/04

CPC分类号： C07H19/167 ,  A61P35/00 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07H19/04

摘要： The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

公开(公告)号：US20230257371A1

公开(公告)日：2023-08-17

申请号：US18015671

申请日：2021-07-15

申请人： Michael ALTMAN ,  David A. CANDITO ,  Alec H. CHRISTIAN ,  Ornella DI PIETRO ,  Min LU ,  Umar Faruk MANSOOR ,  Katrina Marie MENNIE ,  Andrew J. MUSACCHIO ,  Anandan PALANI ,  Michael H. REUTERSHAN ,  David Matthew SHAW ,  MERCK SHARP & DOHME LLC ,  MSD R&D INNOVATION CENTRE LIMITED

发明人： Michael D. Altman ,  David A. Canditio ,  Alec H. Christian ,  Ornella Di Pietro ,  Min Lu ,  Umar Faruk Mansoor ,  Katrina Marie Mennie ,  Andrew J. Musacchio ,  Anandan Palani ,  Michael H. Reutershan ,  David Matthew Shaw ,  Ping Lui ,  Stephen St-Gallay

IPC分类号： C07D413/04 ,  C07D403/06 ,  C07D265/36 ,  C07D401/06 ,  C07D491/048 ,  C07D471/04 ,  C07D209/96 ,  C07D487/04 ,  C07D307/94

CPC分类号： C07D413/04 ,  C07D403/06 ,  C07D265/36 ,  C07D401/06 ,  C07D491/048 ,  C07D471/04 ,  C07D209/96 ,  C07D487/04 ,  C07D307/94

摘要： The present invention relates to cyclic cyanoenone derivatives of Formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein R1, R2, R3, R4 and m are as defined herein. The present invention also relates to pharmaceutical compositions comprising the cyclic cyanoenone derivatives of Formula (I) and to their use in therapy.

公开(公告)号：US11993602B2

公开(公告)日：2024-05-28

申请号：US17266474

申请日：2019-08-05

申请人： Merck Sharp & Dohme LLC ,  David Witter ,  Shuhei Kawamura ,  Michelle Machacek ,  Ryan Quiroz ,  Michael H. Reutershan ,  Sebastian Schneider ,  Phieng Siliphaivanh ,  Yingchun Ye ,  Charles S. Yeung

发明人： David Witter ,  Shuhei Kawamura ,  Michelle Machacek ,  Ryan Quiroz ,  Michael H. Reutershan ,  Sebastian Schneider ,  Phieng Siliphaivanh ,  Yingchun Ye ,  Charles S. Yeung

IPC分类号： C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D519/00

摘要： The present invention provides a compound of Formula (I) Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

公开(公告)号：US20230114091A1

公开(公告)日：2023-04-13

申请号：US17783967

申请日：2020-12-14

申请人： Merck Sharp & Dohme LLC

发明人： Michelle Machacek ,  Michael D. Altman ,  Shuhei Kawamura ,  Michael H. Reutershan ,  David L. Sloman ,  Phieng Siliphaivanh ,  Sebastian E. Schneider ,  Charles S. Yeung ,  David J. Witter ,  Craig R. Gibeau

IPC分类号： C07D471/10 ,  C07D519/00

摘要： The present invention provides a compound of Formula (I) (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.