公开(公告)号：US20220388974A1

公开(公告)日：2022-12-08

申请号：US17749452

申请日：2022-05-20

申请人： Merck Sharp & Dohme LLC ,  Werthenstein Biopharma GMBH

发明人： Stephen M. Dalby ,  Clinton Scott Shultz ,  Chintal Desai ,  Joshua Lee ,  Zhiwei Chen ,  Jungchul Kim ,  Nastaran Salehi Marzijarani ,  Tao Wang ,  Eric M. Phillips ,  Patrick Larpent ,  Het P. Patel ,  Haiheng Guo ,  Xin Wang ,  Kangze Dai ,  Lu Chen ,  Teng Li ,  Taotao Lu ,  Jianjun Duan

IPC分类号： C07D317/72 ,  C07C317/14

摘要： The disclosure provides crystalline forms for certain synthetic intermediates for making belzutifan, a HIF-2α inhibitor, useful for the treatment of cancer. The disclosure also provides processes for isolating the crystalline forms.

公开(公告)号：US11827614B2

公开(公告)日：2023-11-28

申请号：US17749452

申请日：2022-05-20

申请人： Merck Sharp & Dohme LLC ,  Werthenstein Biopharma GMBH

发明人： Stephen M. Dalby ,  Clinton Scott Shultz ,  Chintal Desai ,  Joshua Lee ,  Zhiwei Chen ,  Jungchul Kim ,  Nastaran Salehi Marzijarani ,  Tao Wang ,  Eric M. Phillips ,  Patrick Larpent ,  Het P. Patel ,  Haiheng Guo ,  Xin Wang ,  Kangze Dai ,  Lu Chen ,  Teng Li ,  Taotao Lu ,  Jianjun Duan

IPC分类号： C07D317/72 ,  C07C317/14

CPC分类号： C07D317/72 ,  C07C317/14 ,  C07B2200/13

摘要： The disclosure provides crystalline forms for certain synthetic intermediates for making belzutifan, a HIF-2α inhibitor, useful for the treatment of cancer. The disclosure also provides processes for isolating the crystalline forms.