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公开(公告)号：US20220388974A1
公开(公告)日：2022-12-08
申请号：US17749452
申请日：2022-05-20
发明人： Stephen M. Dalby , Clinton Scott Shultz , Chintal Desai , Joshua Lee , Zhiwei Chen , Jungchul Kim , Nastaran Salehi Marzijarani , Tao Wang , Eric M. Phillips , Patrick Larpent , Het P. Patel , Haiheng Guo , Xin Wang , Kangze Dai , Lu Chen , Teng Li , Taotao Lu , Jianjun Duan
IPC分类号： C07D317/72 , C07C317/14
摘要： The disclosure provides crystalline forms for certain synthetic intermediates for making belzutifan, a HIF-2α inhibitor, useful for the treatment of cancer. The disclosure also provides processes for isolating the crystalline forms.
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公开(公告)号：US20230312887A1
公开(公告)日：2023-10-05
申请号：US18022570
申请日：2021-09-08
发明人： David J. Lamberto , Paolo Avalle , Lorenzo Codan , Patrick Larpent , Jochen Schoell , Jeffrey S. Neuhaus
CPC分类号： C08L5/16 , C08B37/0012
摘要： The present invention relates to a process for drying crystalline sugammadex to meet solvent specifications that is independent of API crystallinity or crystalline form generated. It further relates to use of sugammadex in the reversal of neuromuscular blockade induced by recuronium bromide or by vecuronium bromide in adults undergoing surgery.
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公开(公告)号：US11827614B2
公开(公告)日：2023-11-28
申请号：US17749452
申请日：2022-05-20
发明人： Stephen M. Dalby , Clinton Scott Shultz , Chintal Desai , Joshua Lee , Zhiwei Chen , Jungchul Kim , Nastaran Salehi Marzijarani , Tao Wang , Eric M. Phillips , Patrick Larpent , Het P. Patel , Haiheng Guo , Xin Wang , Kangze Dai , Lu Chen , Teng Li , Taotao Lu , Jianjun Duan
IPC分类号： C07D317/72 , C07C317/14
CPC分类号： C07D317/72 , C07C317/14 , C07B2200/13
摘要： The disclosure provides crystalline forms for certain synthetic intermediates for making belzutifan, a HIF-2α inhibitor, useful for the treatment of cancer. The disclosure also provides processes for isolating the crystalline forms.
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公开(公告)号：US20210122717A1
公开(公告)日：2021-04-29
申请号：US17048833
申请日：2019-04-18
发明人： Kevin M. Maloney , Kallol Basu , John Y.L. Chung , Richard Desmond , Michael James Di Maso , Guy R. Humphrey , Alfred Y. Lee , Dan Lehnherr , Feng Peng , Hong Ren , Mark Weisel , Siwei Zhang , Patrick Larpent
IPC分类号： C07D239/48 , C07D487/18 , C07C41/09 , C07C41/30 , C07C253/30
摘要： Disclosed herein is a novel process for preparing Compound A free base, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-iso-propyl-2-methoxybenzenesulfonamide, and a citrate salt of Compound A with simplified chemistry and a high overall yield: Compound A. In one embodiment, the overall yield from the starting material 2-isopropylphenol to Compound A citrate salt is greater than 50%. In another embodiment, the overall yield is greater than 60%. Also disclosed herein are novel salts and solvates of Compound A.
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