公开(公告)号：US20230352118A1

公开(公告)日：2023-11-02

申请号：US18311138

申请日：2023-05-02

Applicant: Merck Sharp and Dohme LLC

Inventor： Yara Seif ,  Xiao Xiao ,  Kevin Teng ,  Ming-Tang Chen ,  Alan C. Cheng ,  BoRam Lee ,  Isha Verma

IPC: G16B30/10 ,  G16B5/00

CPC classification number: G16B30/10 ,  G16B5/00

Abstract: A computer-implemented method is disclosed for candidate antibody exploration. The method includes receiving sequence reads from a sequencing system, wherein each sequence read comprises a target gene for expressing a candidate antibody, wherein each sequence read is associated with a binding affinity to a target antigen. The method includes generating a sequence representation for each sequence read, representing the amino acid sequences of the sequence read. The method includes training a binding affinity prediction model with the sequence representations and the binding affinities. The method includes generating a synthetic candidate sequence read that is different from the sequence reads. The method includes generating a sequence representation for the synthetic candidate sequence read. The method includes determining a binging affinity prediction for the synthetic candidate sequence read by applying the binding affinity prediction model to the sequence representation for the synthetic candidate sequence read.