公开(公告)号：US08841477B2

公开(公告)日：2014-09-23

申请号：US12503239

申请日：2009-07-15

Applicant: Merritt B. Andrus ,  Jing Liu

Inventor： Merritt B. Andrus ,  Jing Liu

IPC: C07C69/88 ,  C07C67/29 ,  C07C69/017 ,  C07C67/287 ,  C07C67/293 ,  C07C67/08 ,  C07C67/14

CPC classification number: C07C69/017 ,  C07C67/08 ,  C07C67/14 ,  C07C67/287 ,  C07C67/29 ,  C07C67/293 ,  Y02P20/55 ,  C07C69/716 ,  C07C69/63 ,  C07C69/18 ,  C07C69/16

Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from 2 to 6 carbon atoms and cycloalkyl of from 3 to 8 carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

Abstract translation: 本发明包括用于制备下列给出的式的白藜芦醇，白藜芦醇酯和取代和未取代的二苯乙烯的方法; 其中每个Y是-O或卤素，每个Z是-O或卤素，每个n和每个m独立地是0,1,2,3,4或5的值，每个A和每个B独立地选自Pn， R或不存在，每个V和每个W独立地选自Pn，2至6个碳原子的直链或支链烷基和3至8个碳原子的环烷基，烷氧基，苯基，苄基或卤素，R独立地选自 包含至少一个碳原子的烷基，芳基和芳烷基，Pn是上述的醇保护基和非对映异构体。 所述化合物由多步法制备，包括在碱存在下与苄氧基卤化物和苯乙烯偶联配偶体的N-杂环卡宾型配体偶联。 这些化合物在食品，化妆品和制药工业中显示出增加的稳定性。

公开(公告)号：US20100185006A1

公开(公告)日：2010-07-22

申请号：US12503239

申请日：2009-07-15

Applicant: Merritt B. Andrus ,  Jing Liu

Inventor： Merritt B. Andrus ,  Jing Liu

IPC: C07C37/01 ,  C07C67/39

CPC classification number: C07C69/017 ,  C07C67/08 ,  C07C67/14 ,  C07C67/287 ,  C07C67/29 ,  C07C67/293 ,  Y02P20/55 ,  C07C69/716 ,  C07C69/63 ,  C07C69/18 ,  C07C69/16

Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from 2 to 6 carbon atoms and cycloalkyl of from 3 to 8 carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

Abstract translation: 本发明包括用于制备下列给出的式的白藜芦醇，白藜芦醇酯和取代和未取代的二苯乙烯的方法; 其中每个Y是-O或卤素，每个Z是-O或卤素，每个n和每个m独立地是0,1,2,3,4或5的值，每个A和每个B独立地选自Pn， R或不存在，每个V和每个W独立地选自Pn，2至6个碳原子的直链或支链烷基和3至8个碳原子的环烷基，烷氧基，苯基，苄基或卤素，R独立地选自 包含至少一个碳原子的烷基，芳基和芳烷基，Pn是上述的醇保护基和非对映异构体。 所述化合物由多步法制备，包括在碱存在下与苄氧基卤化物和苯乙烯偶联配偶体的N-杂环卡宾型配体偶联。 这些化合物在食品，化妆品和制药工业中显示出增加的稳定性。

公开(公告)号：US07714161B2

公开(公告)日：2010-05-11

申请号：US10597335

申请日：2005-01-19

Applicant: Merritt B. Andrus ,  Jing Liu

Inventor： Merritt B. Andrus ,  Jing Liu

IPC: C07C69/88

CPC classification number: C07C69/017 ,  C07C67/08 ,  C07C67/14 ,  C07C67/287 ,  C07C67/29 ,  C07C67/293 ,  Y02P20/55 ,  C07C69/716 ,  C07C69/63 ,  C07C69/18 ,  C07C69/16

Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from (2) to (6) carbon atoms and cycloalkyl of from (3) to (8) carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

Abstract translation: 本发明包括用于制备下列给出的式的白藜芦醇，白藜芦醇酯和取代和未取代的二苯乙烯的方法; 其中每个Y是-O或卤素，每个Z是-O或卤素，每个n和每个m独立地是0,1,2,3,4或5的值，每个A和每个B独立地选自Pn， R或不存在，每个V和每个W独立地选自（2）至（6）个碳原子的直链或支链烷基，（3）至（8）碳原子的烷基，烷氧基，苯基，苄基或 卤素，R独立地选自烷基与至少一个碳原子的基团，芳基和芳烷基，Pn是醇保护基和前述的非对映异构体。 所述化合物由多步法制备，包括在碱存在下与苄氧基卤化物和苯乙烯偶联配偶体的N-杂环卡宾型配体偶联。 这些化合物在食品，化妆品和制药工业中显示出增加的稳定性。

公开(公告)号：US20080255382A1

公开(公告)日：2008-10-16

申请号：US10597335

申请日：2005-01-19

Applicant: Merritt B. Andrus ,  Jing Liu

Inventor： Merritt B. Andrus ,  Jing Liu

IPC: C07C67/40 ,  C07C37/01

CPC classification number: C07C69/017 ,  C07C67/08 ,  C07C67/14 ,  C07C67/287 ,  C07C67/29 ,  C07C67/293 ,  Y02P20/55 ,  C07C69/716 ,  C07C69/63 ,  C07C69/18 ,  C07C69/16

Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from (2) to (6) carbon atoms and cycloalkyl of from (3) to (8) carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbon-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

Abstract translation: 本发明包括用于制备下列给出的式的白藜芦醇，白藜芦醇酯和取代和未取代的二苯乙烯的方法; 其中每个Y是-O或卤素，每个Z是-O或卤素，每个n和每个m独立地是0,1,2,3,4或5的值，每个A和每个B独立地选自P < R或不存在，每个V和每个W独立地选自（2）至（6）个碳原子的直链或支链烷基和 （3）至（8）碳原子，烷氧基，苯基，苄基或卤素，R独立地选自烷基与至少一个碳原子，芳基和芳烷基， 保护前述的基团和非对映异构体。 该化合物由多步法制备，包括在碱存在下与苄氧基卤化物和苯乙烯偶联配偶体偶联的N-杂环碳型配体。 这些化合物在食品，化妆品和制药工业中显示出增加的稳定性。

公开(公告)号：US20130123357A1

公开(公告)日：2013-05-16

申请号：US13641449

申请日：2011-04-13

Applicant: Edwin Douglas Lephart ,  Merritt B. Andrus

Inventor： Edwin Douglas Lephart ,  Merritt B. Andrus

IPC: A61K31/216

CPC classification number: A61K31/216 ,  A61K31/05

Abstract: The present invention relates to a method of providing enhanced resveratrol activity comprising: administering a therapeutically effective amount of 4-acetoxy-resveratrol for the treatment of and preventing physiological and pathophysiological conditions mediated by (1) sirtuins, (2) estrogen and anti-estrogen hormone actions and (3) chemical interventions important for male and female health, aging, anti-aging and age-related disorders.

Abstract translation: 本发明涉及一种提供增强的白藜芦醇活性的方法，其包括：施用治疗有效量的4-乙酰氧基 - 白藜芦醇，用于治疗和预防（1）sirtin，（2）雌激素和抗雌激素介导的生理和病理生理条件 激素作用和（3）对男性和女性健康，衰老，抗衰老和年龄相关疾病重要的化学干预。