公开(公告)号：US20020086335A1

公开(公告)日：2002-07-04

申请号：US10007526

申请日：2001-12-05

Applicant: Meso Scale Technology LLP

Inventor： Richard J. Massey ,  Mark T. Martin ,  Liwen Dong ,  Ming Lu ,  Alan Fischer ,  Fabian Jameison ,  Pam Liang ,  Robert Hoch ,  Jonathan K. Leland

IPC: G01N033/53 ,  C12N009/00 ,  G01F001/64 ,  G01N027/26

CPC classification number: C01B31/0213 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/152 ,  C01B32/174 ,  C01B2202/34 ,  C01B2202/36 ,  C07K17/06 ,  D01F9/12 ,  D01F11/14 ,  G01N21/69 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/582 ,  G01N2030/8863 ,  G11C13/025 ,  H01M4/60 ,  Y10S435/968 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S977/737 ,  Y10S977/742

Abstract: Graphitic nanotubes, which include tubular fullerenes (commonly called nullbuckytubesnull) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.