公开(公告)号：US11933671B2

公开(公告)日：2024-03-19

申请号：US18218651

申请日：2023-07-06

Applicant: MetGen, Incorporated

Inventor： Richard D. Shunnarah ,  Hugh F. Garvey ,  Lenzi J. Williams ,  Devon Fish

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65 ,  G01N33/52 ,  G01N33/68 ,  G01N3/44

CPC classification number: G01J3/0272 ,  G01J3/0256 ,  G01J3/4412 ,  G01N21/658 ,  G01N33/523 ,  G01N33/6812

Abstract: A gold nanoporous anodic aluminum oxide (NAAO) substrate used in coordination with a handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting phenylalanine (Phe) in a sample collected from a subject, the gold NAAO substrate comprising a multilayered nanoporous aluminum layer; and a gold layer disposed on top of the multilayered nanoporous aluminum layer. The gold layer comprises gold nanoparticles.

公开(公告)号：US20230349756A1

公开(公告)日：2023-11-02

申请号：US18218669

申请日：2023-07-06

Applicant: MetGen, Incorporated

Inventor： Richard D. Shunnarah ,  Hugh F. Garvey ,  Lenzi J. Williams ,  Devon Fish

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/68 ,  G01N33/52 ,  G01J3/02

CPC classification number: G01J3/0272 ,  G01J3/0256 ,  G01J3/4412 ,  G01N21/658 ,  G01N33/523 ,  G01N33/6812

Abstract: A method for fabrication of a gold nanoporous anodic aluminum oxide (NAAO) substrate used in coordination with a handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting phenylalanine (Phe) in a sample collected from a subject, the method comprising forming a three-phase system on top of a multilayered nanoporous aluminum layer of the gold NAAO substrate; injecting a cosolvent solution into the three-phase system, wherein the cosolvent solution comprises gold nanoparticles; forming a gold layer on top of the multilayered nanoporous aluminum layer, and drying the gold NAAO substrate.

公开(公告)号：US11747199B2

公开(公告)日：2023-09-05

申请号：US17888621

申请日：2022-08-16

Applicant: MetGen, Incorporated

Inventor： Richard D. Shunnarah ,  Hugh F. Garvey ,  Lenzi J. Williams ,  Devon Fish

IPC: G01J3/02 ,  G01N33/52 ,  G01N21/65 ,  G01J3/44 ,  G01N33/68

CPC classification number: G01J3/0272 ,  G01J3/0256 ,  G01J3/4412 ,  G01N21/658 ,  G01N33/523 ,  G01N33/6812

Abstract: A handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting phenylalanine (Phe) in a sample collected from a subject, the device comprising a laser generator configured to produce a laser beam; a nanoporous anodic aluminum oxide (NAAO) substrate configured to receive the sample collected from the subject; and a light sensor configured to receive a light.

公开(公告)号：US20240183711A1

公开(公告)日：2024-06-06

申请号：US18441250

申请日：2024-02-14

Applicant: MetGen, Incorporated

Inventor： Richard D. Shunnarah ,  Hugh F. Garvey ,  Lenzi J. williams ,  Devon Fish

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65 ,  G01N33/52 ,  G01N33/68

CPC classification number: G01J3/0272 ,  G01J3/0256 ,  G01J3/4412 ,  G01N21/658 ,  G01N33/523 ,  G01N33/6812

Abstract: A handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting a biomarker in a sample collected from a subject. The device comprises a laser generator configured to produce a laser beam; a nanoporous anodic aluminum oxide (NAAO) substrate configured to receive the sample collected from the subject; wherein the laser beam reaches the sample on the NAAO substrate and is reflected or deflected to produce a light signal; and a light sensor configured to receive the light signal reflected or deflected from the sample; wherein the device is handheld and detects the biomarker in the sample; wherein the NAAO substrate comprises a multilayered nanoporous aluminum layer; wherein the multilayered nanoporous aluminum layer comprises a base aluminum layer, and a nanoporous aluminum layer on top of the base aluminum layer; and wherein the nanoporous aluminum layer comprises a plurality of nanocavities.

公开(公告)号：US11933672B2

公开(公告)日：2024-03-19

申请号：US18218669

申请日：2023-07-06

Applicant: MetGen, Incorporated

Inventor： Richard D. Shunnarah ,  Hugh F. Garvey ,  Lenzi J. Williams ,  Devon Fish

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65 ,  G01N33/52 ,  G01N33/68 ,  G01N33/50

CPC classification number: G01J3/0272 ,  G01J3/0256 ,  G01J3/4412 ,  G01N21/658 ,  G01N33/523 ,  G01N33/6812

Abstract: A method for fabrication of a gold nanoporous anodic aluminum oxide (NAAO) substrate used in coordination with a handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting phenylalanine (Phe) in a sample collected from a subject, the method comprising forming a three-phase system on top of a multilayered nanoporous aluminum layer of the gold NAAO substrate; injecting a cosolvent solution into the three-phase system, wherein the cosolvent solution comprises gold nanoparticles; forming a gold layer on top of the multilayered nanoporous aluminum layer, and drying the gold NAAO substrate.

公开(公告)号：US12196613B2

公开(公告)日：2025-01-14

申请号：US18441250

申请日：2024-02-14

Applicant: MetGen, Incorporated

Inventor： Richard D. Shunnarah ,  Hugh F. Garvey ,  Lenzi J. Williams ,  Devon Fish

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65 ,  G01N33/52 ,  G01N33/68

Abstract: A handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting a biomarker in a sample collected from a subject. The device comprises a laser generator configured to produce a laser beam; a nanoporous anodic aluminum oxide (NAAO) substrate configured to receive the sample collected from the subject; wherein the laser beam reaches the sample on the NAAO substrate and is reflected or deflected to produce a light signal; and a light sensor configured to receive the light signal reflected or deflected from the sample; wherein the device is handheld and detects the biomarker in the sample; wherein the NAAO substrate comprises a multilayered nanoporous aluminum layer; wherein the multilayered nanoporous aluminum layer comprises a base aluminum layer, and a nanoporous aluminum layer on top of the base aluminum layer; and wherein the nanoporous aluminum layer comprises a plurality of nanocavities.

公开(公告)号：US20230358609A1

公开(公告)日：2023-11-09

申请号：US18218651

申请日：2023-07-06

Applicant: MetGen, Incorporated

Inventor： Richard D. Shunnarah ,  Hugh F. Garvey ,  Lenzi J. Williams ,  Devon Fish

IPC: G01J3/02 ,  G01N33/52 ,  G01N21/65 ,  G01J3/44 ,  G01N33/68

CPC classification number: G01J3/0272 ,  G01N33/523 ,  G01J3/0256 ,  G01N21/658 ,  G01J3/4412 ,  G01N33/6812

Abstract: A gold nanoporous anodic aluminum oxide (NAAO) substrate used in coordination with a handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting phenylalanine (Phe) in a sample collected from a subject, the gold NAAO substrate comprising a multilayered nanoporous aluminum layer; and a gold layer disposed on top of the multilayered nanoporous aluminum layer. The gold layer comprises gold nanoparticles.

公开(公告)号：US20230057894A1

公开(公告)日：2023-02-23

申请号：US17888621

申请日：2022-08-16

Applicant: MetGen, Incorporated

Inventor： Richard D. Shunnarah ,  Hugh F. Garvey ,  Lenzi J. Williams ,  Devon Fish

IPC: G01J3/02 ,  G01N33/52 ,  G01N33/68 ,  G01N21/65 ,  G01J3/44

Abstract: A handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting phenylalanine (Phe) in a sample collected from a subject, the device comprising a laser generator configured to produce a laser beam; a nanoporous anodic aluminum oxide (NAAO) substrate configured to receive the sample collected from the subject; and a light sensor configured to receive a light.