公开(公告)号：US20070110834A1

公开(公告)日：2007-05-17

申请号：US10581576

申请日：2004-12-03

申请人： Mi Jin ,  Jae Ryu ,  Hyoun Choi ,  Hyun Jung ,  Kyoung Park ,  Sun Kim

发明人： Mi Jin ,  Jae Ryu ,  Hyoun Choi ,  Hyun Jung ,  Kyoung Park ,  Sun Kim

IPC分类号： A61K36/42 ,  A61K31/343

CPC分类号： A61K31/343 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/42 ,  A23V2200/332

摘要： The present invention is related to an alcohol compound isolated from the extract of Cucurbitaceae family plant having anti-adipogenic and anti-obesity activity, and a composition comprising the same. The compound showed potent reducing activity of body weight, decreasing effect on the blood triglyceride and cholesterol level, activating activity of PPAR alpha and preventing activity from the adipogenesis of precursor fat cells with no toxicity, therefore, those compound can be useful in treating or preventing obesity and adipogenesis-involved diseases as a medicine or health care food.

摘要翻译： 本发明涉及从具有抗脂肪生成和抗肥胖活性的葫芦科家族植物提取物中分离的醇化合物和包含其的组合物。 该化合物显示出有效的体重减少活性，降低对血液甘油三酯和胆固醇水平的影响，激活PPARα的活性并防止前体脂肪细胞的脂肪形成的活性，无毒性，因此，这些化合物可用于治疗或预防 肥胖和脂肪生成涉及疾病作为医药或保健食品。

公开(公告)号：US20070110833A1

公开(公告)日：2007-05-17

申请号：US10581575

申请日：2004-12-03

申请人： Mi Jin ,  Jae Ryu ,  Hyoun Choi ,  Hyun Jung ,  Kyoung Park ,  Sun Kim

发明人： Mi Jin ,  Jae Ryu ,  Hyoun Choi ,  Hyun Jung ,  Kyoung Park ,  Sun Kim

IPC分类号： A61K36/42

CPC分类号： A61K36/42

摘要： The present invention is related to an extract of Cucurbitaceae family plant or the purified extract isolated therefrom having anti-adipogenic and anti-obesity activity, and a composition comprising the same. The extract of Cucurbitaceae family plant of the present invention showed potent reducing activity of body weight, decreasing effect on the blood triglyceride and cholesterol level, activating activity of PPAR α and δ, reducing activity of the gene expression of stearoyl-CoA desaturase, and preventing activity from the adipogenesis of precursor fat cells with no toxicity, therefore, those extract can be useful in treating or preventing obesity and adipogenesis-involved diseases as a medicine or health care food.

摘要翻译： 本发明涉及葫芦科家族植物提取物或其分离自其的具有抗脂肪生成和抗肥胖活性的纯化提取物及其组合物。 本发明的葫芦科植物提取物显示出有效的体重降低活性，降低对血液甘油三酯和胆固醇水平的影响，激活PPARα和δ的活性，降低硬脂酰辅酶A去饱和酶基因表达的活性，并预防 前体脂肪细胞的脂肪形成活性无毒性，因此，这些提取物可用于治疗或预防作为药物或保健食品的肥胖和脂肪生成相关疾病。