公开(公告)号：US5866402A

公开(公告)日：1999-02-02

申请号：US435149

申请日：1995-05-05

申请人： Michael A. Innis ,  Isabel Zaror ,  Abla A. Creasey

发明人： Michael A. Innis ,  Isabel Zaror ,  Abla A. Creasey

IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K14/705 ,  C07K19/00 ,  C12N15/62

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

摘要： Chimeric proteins containing sequences from MCP and DAF and further containing peptide sequences capable of binding glycosaminoglycans. Nucleotide sequences encoding the chimeric proteins, expression vectors containing the nucleotide sequences, as well as transformed host cells capable of producing the chimeric proteins are claimed.

摘要翻译： 含有来自MCP和DAF的序列并进一步含有能结合糖胺聚糖的肽序列的嵌合蛋白。 要求编码嵌合蛋白的核苷酸序列，含有核苷酸序列的表达载体以及能够产生嵌合蛋白质的转化的宿主细胞。

公开(公告)号：US06783960B2

公开(公告)日：2004-08-31

申请号：US09741106

申请日：2000-12-21

申请人： Michael A. Innis ,  Abla A. Creasey

发明人： Michael A. Innis ,  Abla A. Creasey

IPC分类号： C07K1400

CPC分类号： C07K14/8114 ,  A61K38/00 ,  C07K2319/00

摘要： Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.

摘要翻译： 公开了具有TFPI-2的Kunitz型结构域1和TFPI的Kunitz型结构域2的嵌合蛋白质，以及TFPI和TFPI-2的突变蛋白。 还公开了核酸序列，表达载体和编码并能够产生所公开的嵌合蛋白和突变蛋白的转化宿主细胞。 最后，公开了使用嵌合蛋白质和突变蛋白质预防和治疗败血性休克的方法。

公开(公告)号：US6103500A

公开(公告)日：2000-08-15

申请号：US854764

申请日：1997-05-12

申请人： Michael A. Innis ,  Abla A. Creasey

发明人： Michael A. Innis ,  Abla A. Creasey

IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K14/81 ,  C12N1/19 ,  C12N15/15 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  C12N15/00 ,  C07K19/00

CPC分类号： C12N15/81 ,  C07K14/8114 ,  A61K38/00

摘要： A method for the production of Tissue Factor Pathway Inhibitor (TFPI) and Tissue Factor Pathway Inhibitor 2 (TFPI-2), and muteins thereof is disclosed wherein the protein is retained within a yeast cell during growth of the yeast cell and recovered from an insoluble fraction prepared from yeast cells containing the protein.

摘要翻译： 公开了一种生产组织因子途径抑制剂（TFPI）和组织因子途径抑制剂2（TFPI-2）的方法及其突变蛋白，其中蛋白质在酵母细胞生长期间保留在酵母细胞内并从不溶性 从含有蛋白质的酵母细胞制备的级分。

公开(公告)号：US5589359A

公开(公告)日：1996-12-31

申请号：US286521

申请日：1994-08-05

申请人： Michael A. Innis ,  Abla A. Creasey

发明人： Michael A. Innis ,  Abla A. Creasey

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  A61P7/02 ,  A61P31/04 ,  C07K14/81 ,  C07K16/38 ,  C07K19/00 ,  C12N1/19 ,  C12N15/15 ,  C12P21/02 ,  C12P21/08 ,  A61K38/36 ,  A61K38/57 ,  C07K14/745 ,  C12N15/63

CPC分类号： C07K14/8114 ,  A61K38/00 ,  C07K2319/00

摘要： Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.

公开(公告)号：US06174721B1

公开(公告)日：2001-01-16

申请号：US08943682

申请日：1997-10-14

申请人： Michael A. Innis ,  Abla A. Creasey

发明人： Michael A. Innis ,  Abla A. Creasey

IPC分类号： C12N1562

CPC分类号： C07K14/8114 ,  A61K38/00 ,  C07K2319/00

摘要： Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.

摘要翻译： 公开了具有TFPI-2的Kunitz型结构域1和TFPI的Kunitz型结构域2的嵌合蛋白质，以及TFPI和TFPI-2的突变蛋白。 还公开了核酸序列，表达载体和编码并能够产生所公开的嵌合蛋白和突变蛋白的转化宿主细胞。 最后，公开了使用嵌合蛋白质和突变蛋白质预防和治疗败血性休克的方法。

公开(公告)号：US5696088A

公开(公告)日：1997-12-09

申请号：US436175

申请日：1995-05-09

申请人： Michael A. Innis ,  Abla A. Creasey

发明人： Michael A. Innis ,  Abla A. Creasey

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  A61P7/02 ,  A61P31/04 ,  C07K14/81 ,  C07K16/38 ,  C07K19/00 ,  C12N1/19 ,  C12N15/15 ,  C12P21/02 ,  C12P21/08 ,  A61K38/36 ,  A61K38/16

CPC分类号： C07K14/8114 ,  A61K38/00 ,  C07K2319/00

摘要： Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.

摘要翻译： 公开了具有TFPI-2的Kunitz型结构域1和TFPI的Kunitz型结构域2的嵌合蛋白质，以及TFPI和TFPI-2的突变蛋白。 还公开了核酸序列，表达载体和编码并能够产生所公开的嵌合蛋白和突变蛋白的转化宿主细胞。 最后，公开了使用嵌合蛋白质和突变蛋白质预防和治疗败血性休克的方法。

公开(公告)号：US5563123A

公开(公告)日：1996-10-08

申请号：US437841

申请日：1995-05-09

申请人： Michael A. Innis ,  Abla A. Creasey

发明人： Michael A. Innis ,  Abla A. Creasey

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  A61P7/02 ,  A61P31/04 ,  C07K14/81 ,  C07K16/38 ,  C07K19/00 ,  C12N1/19 ,  C12N15/15 ,  C12P21/02 ,  C12P21/08 ,  A61K38/57 ,  A61K38/36

CPC分类号： C07K14/8114 ,  A61K38/00 ,  C07K2319/00

摘要： Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.

公开(公告)号：US6063764A

公开(公告)日：2000-05-16

申请号：US472761

申请日：1995-06-07

申请人： Abla A. Creasey ,  George J. Broze

发明人： Abla A. Creasey ,  George J. Broze

IPC分类号： A61K38/57 ,  A61K38/00

CPC分类号： A61K38/57 ,  Y10S514/921

摘要： A method for prophylactically or therapeutically treating sepsis or septic shock is described, wherein an inhibitor to tissue factor is administered to septic patients. Additionally, a method for treating inflammation is described wherein the inhibitor is administered to pateints. This inhibitor is termed lipoprotein associated coagulation inhibitor, or commonly LACI. It is 38 kD and has 276 amino acids. LACI has now been shown to be useful for the treatment of sepsis, septic shock and inflammation.

公开(公告)号：US20090215695A1

公开(公告)日：2009-08-27

申请号：US12434935

申请日：2009-05-04

申请人： Kirk Johnson ,  Abla A. Creasey ,  Lucien A. Aarden

发明人： Kirk Johnson ,  Abla A. Creasey ,  Lucien A. Aarden

IPC分类号： A61K38/17

CPC分类号： A61K38/57 ,  A01K2217/05 ,  C07K14/705 ,  C07K2319/00

摘要： Methods of treatment and prevention of diseases associated with release of neutrophil elastase and IL-8 by administration of TFPI and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI, and the ultimate determination of patient prognosis are also disclosed.

摘要翻译： 公开了通过施用TFPI和TFPI的类似物来治疗和预防与释放嗜中性粒细胞弹性蛋白酶和IL-8相关的疾病的方法。 还公开了确定TFPI治疗效果的方法，患者对TFPI治疗的反应性以及患者预后的最终确定。

公开(公告)号：US5885781A

公开(公告)日：1999-03-23

申请号：US486384

申请日：1995-06-07

申请人： Kirk Johnson ,  Abla A. Creasey ,  Lucien A. Aarden

发明人： Kirk Johnson ,  Abla A. Creasey ,  Lucien A. Aarden

IPC分类号： A61K38/57 ,  G01N33/53 ,  A01N37/18 ,  A61K45/00 ,  G01N33/48

CPC分类号： A61K38/57

摘要： Methods of treatment and prevention of diseases associated with release ofeutrophil elastase and IL-8 by administration of TFPI, and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI and the ultimate determination of patient prognosis are also disclosed.