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79 条记录 (耗时 0.046 秒)

    Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
    1.
    发明授权
    Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof 有权
    脱氢苯基乙二烯和其类似物，以及脱氢苯基黑曲霉素及其类似物的合成

    公开(公告)号：US07935704B2

    公开(公告)日：2011-05-03

    申请号：US11051268

    申请日：2005-02-04

    申请人： Michael A. Palladino ,  George Kenneth Lloyd ,  Yoshio Hayashi ,  Benjamin Nicholson

    发明人： Michael A. Palladino ,  George Kenneth Lloyd ,  Yoshio Hayashi ,  Benjamin Nicholson

    IPC分类号： A61K31/497

    CPC分类号： A61K31/496

    摘要： Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1″, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.

    摘要翻译： 公开了由以下结构（I）表示的化合物：制备这种化合物的方法，其中所述方法包括使二酰基二酮哌嗪与第一醛反应以产生中间体化合物; 并使所述中间体化合物与第二醛反应以产生一类具有通式结构的化合物，其中第一种醛和第二种醛选自恶唑烷羧醛，咪唑甲醛，苯甲醛，咪唑甲醛衍生物和苯甲醛衍生物， 从而形成上述化合物，其中R1，R1'，R1“，R2，R3，R4，R5和R6，X1和X2，Y，Z，Z1，Z2，Z3和Z4各自可以以一致的方式分别定义 附带说明。 还公开了治疗血管增生的组合物和方法。

    Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
    4.
    发明授权
    Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds 有权

    公开(公告)号：US07026322B2

    公开(公告)日：2006-04-11

    申请号：US10632688

    申请日：2003-08-01

    申请人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

    发明人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

    IPC分类号： C07D241/06 ,  C07D241/08 ,  A61K31/496 ,  A61K31/00

    CPC分类号： C07D403/06 ,  A61K31/496

    摘要： Methods of using a compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, to treat cancer, and methods for isolating, for formulating, and for administering the compound, salt, and/or pro-drug ester as an antitumor agent, wherein the compound, salt, or pro-drug ester has the following structure: wherein: R1, R2, R5, R7, and R8 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C1-C24 alkyl, unsaturated C1-C24 alkenyl, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, substituted nitro, phenyl, and substituted phenyl groups, R3, R4, and R6 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C1-C12 alkyl, unsaturated C1-C12 alkenyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, and substituted nitro groups, X1 and X2 are separately selected from the group consisting of an oxygen atom, and a sulfur atom, and the dashed bond represents a bond selected from the group consisting of a carbon-carbon single bond and a carbon-carbon double bond. Most preferably, R3 and R4 are hydrogen, and each are involved in hydrogen bonds, and/or the dashed bond is a double bond, such that the chemical backbone of the compound substantially retains a substantially planar conformation.

    Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
    5.
    发明授权
    Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof 有权
    脱氢苯基乙二烯和其类似物，以及脱氢苯基黑曲霉素及其类似物的合成

    公开(公告)号：US07674903B2

    公开(公告)日：2010-03-09

    申请号：US11448948

    申请日：2006-06-07

    申请人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

    发明人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

    IPC分类号： C07D401/04 ,  C07D403/04 ,  A61P35/04 ,  A61P35/02 ,  A61P33/14 ,  A61P33/00

    CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D487/04

    摘要： Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1″, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.

    摘要翻译： 公开了由以下结构（I）表示的化合物：制备这种化合物的方法，其中所述方法包括使二酰基二酮哌嗪与第一醛反应以产生中间体化合物; 并使中间体化合物与第二醛反应以产生具有通式结构的一类化合物，其中第一种醛和第二种醛选自恶唑烷醛，咪唑甲醛，苯甲醛，咪唑甲醛衍生物和苯甲醛衍生物， 从而形成上述化合物，其中R1，R1'，R1“，R2，R3，R4，R5和R6，X1和X2，Y，Z，Z1，Z2，Z3和Z4各自可以以一致的方式分别定义 附带说明。 还公开了治疗癌症和真菌感染的组合物和方法。

    Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
    6.
    发明授权
    Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof 有权
    脱氢苯基乙二烯和其类似物，以及脱氢苯基黑曲霉素及其类似物的合成

    公开(公告)号：US07064201B2

    公开(公告)日：2006-06-20

    申请号：US10632531

    申请日：2003-08-01

    申请人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

    发明人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

    IPC分类号： B68B1/06

    CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D487/04

    摘要： Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1″, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.

    摘要翻译： 公开了由以下结构（I）表示的化合物：制备这种化合物的方法，其中所述方法包括使二酰基二酮哌嗪与第一醛反应以产生中间体化合物; 并使所述中间体化合物与第二醛反应以产生具有通式结构的一类化合物，其中第一种醛和第二种醛选自恶唑烷羧醛，咪唑甲醛，苯甲醛，咪唑甲醛衍生物和苯甲醛衍生物， 从而形成上述化合物，其中R 1，R 1，R 1，R 2，R 2，R 2， R 3，R 4，R 5和R 6，X 1和R 3， X 2，Y，Z，Z 1，Z 2，Z 3和Z 4 可以以与所附描述一致的方式分别定义。 还公开了治疗癌症和真菌感染的组合物和方法。

    Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
    7.
    发明授权
    Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof 有权
    脱氢苯基乙二烯和其类似物，以及脱氢苯基黑曲霉素及其类似物的合成

    公开(公告)号：US07956058B2

    公开(公告)日：2011-06-07

    申请号：US11448924

    申请日：2006-06-07

    申请人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

    发明人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

    IPC分类号： A61K31/497 ,  A61K31/04 ,  A61P35/04

    CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D487/04

    摘要： Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1′, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.

    摘要翻译： 公开了由以下结构（I）表示的化合物：制备这种化合物的方法，其中所述方法包括使二酰基二酮哌嗪与第一醛反应以产生中间体化合物; 并使所述中间体化合物与第二醛反应以产生一类具有通式结构的化合物，其中第一种醛和第二种醛选自恶唑烷羧醛，咪唑甲醛，苯甲醛，咪唑甲醛衍生物和苯甲醛衍生物， 从而形成上述化合物，其中R1，R1'，R1'，R2，R3，R4，R5和R6，X1和X2，Y，Z，Z1，Z2，Z3和Z4各自可以以一致的方式分开定义 附带说明。 还公开了治疗癌症和真菌感染的组合物和方法。