公开(公告)号：US20120128762A1

公开(公告)日：2012-05-24

申请号：US13350326

申请日：2012-01-13

申请人： Michael B. Chancellor ,  Pradeep Tyagi ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C. de Groat ,  Leaf Huang ,  Naoki Yoshimura

发明人： Michael B. Chancellor ,  Pradeep Tyagi ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C. de Groat ,  Leaf Huang ,  Naoki Yoshimura

IPC分类号： A61K9/127 ,  A61K31/575 ,  A61K31/683 ,  A61K31/70 ,  A61P13/10 ,  A61K31/685

CPC分类号： A61K9/127 ,  A61K9/0034 ,  A61K9/1272

摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysfunction.

摘要翻译： 本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍 作为有需要的动物或人类的间质性膀胱炎（IC）。 还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。 特别地，提供了基于脂质体的递送香草素化合物，例如树脂毒素，辣椒素或微量毒素和毒素，例如肉毒杆菌毒素，用于治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍。

公开(公告)号：US08110217B2

公开(公告)日：2012-02-07

申请号：US11546025

申请日：2006-10-11

申请人： Michael B. Chancellor ,  Pradeep Tyagi ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C de Groat ,  Leaf Huang ,  Naoki Yoshimura

发明人： Michael B. Chancellor ,  Pradeep Tyagi ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C de Groat ,  Leaf Huang ,  Naoki Yoshimura

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K9/0034 ,  A61K9/1272 ,  Y02A50/469

摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysfunction.

摘要翻译： 本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍 作为有需要的动物或人类的间质性膀胱炎（IC）。 还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。 特别地，提供了基于脂质体的递送香草素化合物，例如树脂毒素，辣椒素或微量毒素和毒素，例如肉毒杆菌毒素，用于治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍。

公开(公告)号：US20070122466A1

公开(公告)日：2007-05-31

申请号：US11546025

申请日：2006-10-11

申请人： Michael Chancellor ,  Pradeep Tyagi ,  Matthew Fraser ,  Yao-Chi Chuang ,  William de Groat ,  Leaf Huang ,  Naoki Yoshimura

发明人： Michael Chancellor ,  Pradeep Tyagi ,  Matthew Fraser ,  Yao-Chi Chuang ,  William de Groat ,  Leaf Huang ,  Naoki Yoshimura

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K9/0034 ,  A61K9/1272 ,  Y02A50/469

摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysftunction.

摘要翻译： 本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍 作为有需要的动物或人类的间质性膀胱炎（IC）。 还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。 特别地，为了治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍，提供了香草素化合物（例如树脂毒素，辣椒素或微量毒素）和毒素（例如肉毒杆菌毒素）的基于脂质体的递送。

公开(公告)号：US20070028930A1

公开(公告)日：2007-02-08

申请号：US11475834

申请日：2006-06-27

申请人： Michael Chancellor ,  Pradeep Tyagi ,  Jonathan Kaufman

发明人： Michael Chancellor ,  Pradeep Tyagi ,  Jonathan Kaufman

IPC分类号： A61B19/00

CPC分类号： A61K36/38

摘要： To treat premature ejaculation, delay ejaculation, or improve male sexual control, control bladder urgency and/or minimize or alleviate irritated bladder or bladder urgency, an effective amount of St. John's Wort extract rich in hyperforin is administered to a male prior to sexual intercourse, or to a male or female patient otherwise in need thereof.

摘要翻译： 为了治疗早泄，延迟射精或改善男性的性控制，控制膀胱的紧迫性和/或最小化或缓解膀胱或膀胱的急迫性紧迫性，在性交前向男性施用有效量的圣约翰草提取物， ，或对另外需要的男性或女性患者。