公开(公告)号：US20120128762A1

公开(公告)日：2012-05-24

申请号：US13350326

申请日：2012-01-13

申请人： Michael B. Chancellor ,  Pradeep Tyagi ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C. de Groat ,  Leaf Huang ,  Naoki Yoshimura

发明人： Michael B. Chancellor ,  Pradeep Tyagi ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C. de Groat ,  Leaf Huang ,  Naoki Yoshimura

IPC分类号： A61K9/127 ,  A61K31/575 ,  A61K31/683 ,  A61K31/70 ,  A61P13/10 ,  A61K31/685

CPC分类号： A61K9/127 ,  A61K9/0034 ,  A61K9/1272

摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysfunction.

摘要翻译： 本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍 作为有需要的动物或人类的间质性膀胱炎（IC）。 还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。 特别地，提供了基于脂质体的递送香草素化合物，例如树脂毒素，辣椒素或微量毒素和毒素，例如肉毒杆菌毒素，用于治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍。

公开(公告)号：US08110217B2

公开(公告)日：2012-02-07

申请号：US11546025

申请日：2006-10-11

申请人： Michael B. Chancellor ,  Pradeep Tyagi ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C de Groat ,  Leaf Huang ,  Naoki Yoshimura

发明人： Michael B. Chancellor ,  Pradeep Tyagi ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C de Groat ,  Leaf Huang ,  Naoki Yoshimura

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K9/0034 ,  A61K9/1272 ,  Y02A50/469

摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysfunction.

摘要翻译： 本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍 作为有需要的动物或人类的间质性膀胱炎（IC）。 还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。 特别地，提供了基于脂质体的递送香草素化合物，例如树脂毒素，辣椒素或微量毒素和毒素，例如肉毒杆菌毒素，用于治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍。

公开(公告)号：US07063860B2

公开(公告)日：2006-06-20

申请号：US10218797

申请日：2002-08-13

申请人： Michael B. Chancellor ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C. de Groat ,  Leaf Huang ,  Naoki Yoshimura

发明人： Michael B. Chancellor ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C. de Groat ,  Leaf Huang ,  Naoki Yoshimura

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K9/0034

摘要： The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.

公开(公告)号：US20070122466A1

公开(公告)日：2007-05-31

申请号：US11546025

申请日：2006-10-11

申请人： Michael Chancellor ,  Pradeep Tyagi ,  Matthew Fraser ,  Yao-Chi Chuang ,  William de Groat ,  Leaf Huang ,  Naoki Yoshimura

发明人： Michael Chancellor ,  Pradeep Tyagi ,  Matthew Fraser ,  Yao-Chi Chuang ,  William de Groat ,  Leaf Huang ,  Naoki Yoshimura

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K9/0034 ,  A61K9/1272 ,  Y02A50/469

摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysftunction.

摘要翻译： 本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍 作为有需要的动物或人类的间质性膀胱炎（IC）。 还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。 特别地，为了治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍，提供了香草素化合物（例如树脂毒素，辣椒素或微量毒素）和毒素（例如肉毒杆菌毒素）的基于脂质体的递送。

公开(公告)号：US20070003610A1

公开(公告)日：2007-01-04

申请号：US11438912

申请日：2006-05-22

申请人： Michael Chancellor ,  Matthew Fraser ,  Yao-Chi Chuang ,  William de Groat ,  Leaf Huang ,  Naoki Yoshimura

发明人： Michael Chancellor ,  Matthew Fraser ,  Yao-Chi Chuang ,  William de Groat ,  Leaf Huang ,  Naoki Yoshimura

IPC分类号： A61K39/08 ,  A61K9/127 ,  A61K31/16 ,  A61K48/00

CPC分类号： A61K9/127 ,  A61K9/0034

摘要： The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.

摘要翻译： 本发明涉及用于施用基于脂质的载体以治疗各种疾病（包括膀胱炎症，感染，功能障碍和癌症）的组合物和方法。 在各个方面，本发明的组合物和方法可用于向膀胱，泌尿生殖道，胃肠系统，肺系统和其它器官或身体系统延长递送药物，例如抗生素，疼痛治疗和抗癌剂。 特别地，本发明涉及用于治疗膀胱病症（包括疼痛，炎症，失禁和排尿功能障碍）的香草素化合物（例如树脂毒素，辣椒素或微量毒素）和毒素（例如肉毒杆菌毒素）的基于脂质体的递送 。 进一步相关的是单独使用这些载体或与抗体（例如尿布隆蛋白抗体）联合以改善脂质体附着持续时间并提供长期膀胱内药物递送平台的方法。 本发明具体涉及可用于靶向用于药物，肽，多肽或核酸递送的特异性受体的抗体包被的脂质体。 在一个特定方面，本发明涉及用抗神经生长因子（NGF）受体和含有NGF反义核酸的抗体包被的脂质体，其用作神经源性膀胱功能障碍的治疗。