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1.发明授权公开(公告)号：US07579324B2
公开(公告)日：2009-08-25
申请号：US10367105
申请日：2003-02-14
申请人： Michael Burnet , Jan-Hinrich Guse , Hans-Jurgen Gutke , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Jeannette Reichert , Kattie Luyten , Maximilian Busch , Michael Wolff , Moussa Khobzaoui , Simona Margutti , Thomas Meindl , Gene Kim , Laurence Barker
发明人： Michael Burnet , Jan-Hinrich Guse , Hans-Jurgen Gutke , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Jeannette Reichert , Kattie Luyten , Maximilian Busch , Michael Wolff , Moussa Khobzaoui , Simona Margutti , Thomas Meindl , Gene Kim , Laurence Barker
CPC分类号： A61K49/0004 , A61K47/54 , A61K47/545 , A61K47/549
摘要： This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.
摘要翻译： 本发明的特征在于下列化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> T - （ - LC）m，<？in-line-formula description =“ T是一个转运载体，L是分子量高达240道尔顿的键或接头，C是非抗生素治疗剂，m是1,2,3 ，4,5,6,7或8，其中转运载体具有至少2的免疫选择性比，转运载体通过键或接头与非抗生素治疗剂共价结合，并且该化合物具有 免疫选择性比至少为2。
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2.发明申请Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof 审中-公开生物活性化合物的缀合物，其制备和使用方法，其制剂和药物应用公开(公告)号：US20050171342A1
公开(公告)日：2005-08-04
申请号：US10504787
申请日：2003-02-14
申请人： Michael Burnet , Jan-Hinrich Guse , Hans-Jurgen Gutke , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Jeannette Reichert , Kattie Luyten , Maximilian Busch , Michael Wolff , Moussa Khobzaoui , Simona Margutti , Thomas Meindl , Gene Kim , Laurent Barker
发明人： Michael Burnet , Jan-Hinrich Guse , Hans-Jurgen Gutke , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Jeannette Reichert , Kattie Luyten , Maximilian Busch , Michael Wolff , Moussa Khobzaoui , Simona Margutti , Thomas Meindl , Gene Kim , Laurent Barker
CPC分类号： A61K49/0004 , A61K47/54 , A61K47/545 , A61K47/549
摘要： This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.
摘要翻译： 本发明的特征在于下式的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> T - （ - LC） -line-formula description =“In-line Formulas”end =“tail”？> T是转运载体，L是分子量高达240道尔顿的键或接头，C是非抗生素治疗剂， m是1,2,3,4,5,6,7或8，其中转运蛋白具有至少2的免疫选择性比，所述转运载体通过所述键或所述非抗生素治疗剂共价结合， 接头，并且化合物的免疫选择性比至少为2。
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